surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2025-15-1-50-56surgonco-1052Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSКросслинкинг биополимеров: применение и перспективыBiopolymer crosslinking: Application and prospectshttps://orcid.org/0000-0002-9476-8883БикбовМ. М.BikbovM. M.

Бикбов Мухаррам Мухтарамович — д.м.н., профессор, кафедра офтальмологии с курсом оптического приборостроения

Республика Башкортостан, Уфа

Mukharram M. Bikbov — Dr. Sci. (Med.), Prof., Department of Ophthalmology with a course of Optical Instrument Making

Ufa

https://orcid.org/0000-0002-9581-8918КабировИ. Р.KabirovI. R.

Кабиров Ильдар Раифович — к.м.н., кафедра урологии и онкологии

Республика Башкортостан, Уфа

Ildar R. Kabirov — Cand. Sci. (Med.), Department of Urology and Oncology

Ufa

https://orcid.org/0000-0001-7470-7330ХалимовА. Р.KhalimovA. R.

Халимов Азат Рашидович — д.б.н., научно-инновационный отдел

Республика Башкортостан, Уфа

Azat R. Khalimov — Dr. Sci. (Biol.), Scientific and Innovation Department

Ufa

https://orcid.org/0009-0007-8246-3699НеряхинА. Д.NeryakhinA. D.

Неряхин Александр Дмитриевич — студент 5 курса, педиатрический факультет

Республика Башкортостан, Уфа

Alexander D. Neryakhin — 5th year Student, Faculty of Pediatrics

Ufa

nereahins@mail.ruhttps://orcid.org/0009-0001-3298-3895ШмельковаП. Н.ShmelkovaP. N.

Шмелькова Полина Николаевна — студентка 5 курса, педиатрический факультет

Республика Башкортостан, Уфа

Polina N. Shmelkova — 5th year Student, Faculty of Pediatrics

Ufa

https://orcid.org/0009-0002-9174-4824ГайнуллинаД. Х.GainullinaD. Kh.

Гайнуллина Диана Халиловна — студентка 5 курса, педиатрический факультет

Республика Башкортостан, Уфа

Diana Kh. Gainullina — 5th year Student, Faculty of Pediatrics

Ufa

ГумероваЛ. С.GumerovaL. S.

Гумерова Лейла Сергеевна — студентка 5 курса, педиатрический факультет

Республика Башкортостан, Уфа

Leila S. Gumerova — 5th year Student, Faculty of Pediatrics

Ufa

https://orcid.org/0009-0000-3633-7148ТухбатуллинА. А.TukhbatullinA. A.

Тухбатуллин Альберт Альфредович — студент 5 курса, педиатрический факультет

Республика Башкортостан, Уфа

Albert A. Tukhbatullin — 5th year Student, Faculty of Pediatrics

Ufa

https://orcid.org/0009-0000-9519-3084АхунзяновА. А.AkhunzyanovA. A.

Ахунзянов Азат Алмазович — студент 5 курса, педиатрический факультет

Республика Башкортостан, Уфа

Azat A. Akhunzyanov — 5th year Student, Faculty of Pediatrics

Ufa

https://orcid.org/0000-0002-8129-0665НадеждинаЕ. А.NadezhdinaE. A.

Надеждина Екатерина Андреевна — студентка 6 курса, педиатрический факультет

Республика Башкортостан, Уфа

Ekaterina A. Nadezhdina — 6th year Student

Ufa

Уфимский научно-исследовательский институт глазных болезней, Башкирский государственный медицинский университетРоссияUfa Eye Research Institute, Bashkir State Medical UniversityRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian Federation2025010420251515056Copyright © Бикбов М.М., Кабиров И.Р., Халимов А.Р., Неряхин А.Д., Шмелькова П.Н., Гайнуллина Д.Х., Гумерова Л.С., Тухбатуллин А.А., Ахунзянов А.А., Надеждина Е.А., 20252025Бикбов М.М., Кабиров И.Р., Халимов А.Р., Неряхин А.Д., Шмелькова П.Н., Гайнуллина Д.Х., Гумерова Л.С., Тухбатуллин А.А., Ахунзянов А.А., Надеждина Е.А.Bikbov M.M., Kabirov I.R., Khalimov A.R., Neryakhin A.D., Shmelkova P.N., Gainullina D.K., Gumerova L.S., Tukhbatullin A.A., Akhunzyanov A.A., Nadezhdina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/1052

Кросслинкинг — это метод «сшивания» высокомолекулярных соединений за счет образования новых химических поперечных связей внутри и между макроцепями. При этом в качестве кросслинкеров могут выступать разнообразные агенты — химические соединения, ультрафиолетовое излучение и т. п. Известно, что кросслинкинг биотканей способствует повышению их механической прочности, увеличению структурной плотности и снижению проницаемости биокаркаса. Целью данного обзора является характеристика возможностей применения технологии поперечного сшивания в различных отраслях медицины: офтальмологии, травматологии, урологии, гастроэнтерологии, онкологии, биоинженерии и др. Проведен обзор отечественных и зарубежных публикаций с использованием базы данных и ресурсов поисковых систем научных электронных библиотек: PubMed, elibrary.ru, Google Scholar, Science Direct, а также библиотечного фонда Башкирского государственного медицинского университета за период с 1994 по 2023 г. Исследование доступных литературных источников позволяет заключить, что метод ультрафиолетового кросслинкинга в настоящее время широко применяется в офтальмологии, а различные модификации кросслинкинга имеют перспективы применения в медицине и в смежных отраслях, могут стать основой для создания биоинженерных продуктов и оригинальных медицинских технологий, направленных на повышение эффективности лечения различных заболеваний человека.

Crosslinking is a method of linking together high-molecular compounds by forming new chemical cross linkages inside and between macrochains. At the same time, various agents can act as cross linkers, i.e., chemical compounds, ultraviolet radiation, etc. Crosslinking of biotissues is known for improving their mechanical strength, increasing structural density, and reducing bioscaffold permeability. This review aims to characterize possible applications of cross-linking technology in various branches of medicine, i.e., ophthalmology, traumatology, urology, gastroenterology, oncology, bioengineering, and others. A review of domestic and foreign publications was carried out using the database and resources of search systems of scientific electronic libraries such as PubMed, elibrary.ru, Google Scholar, Science Direct, and the library stock of Bashkir State Medical University for the period from 1994 to 2023. The study of available literature sources makes it possible to conclude that the method of ultraviolet crosslinking is currently widely used in ophthalmology, while various modifications of crosslinking have prospects in medicine and related industries and can become the basis for the creation of bioengineered products and original medical technologies aimed at improving the effectiveness of treatment of various human diseases.

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The authors declare that there are no conflicts of interest present.