surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2014-0-1-2-32-38surgonco-11Research ArticleОПЫТ ЛЕЧЕБНЫХ УЧРЕЖДЕНИЙEXPERIENCE OF HEALTHCARE FACILITIESОЦЕНКА ЭФФЕКТИВНОСТИ ЛЕЧЕНИЯ КОСТНЫХ МЕТАСТАЗОВ САМАРИЕМ-153 ОКСАБИФОРОМ В СОЧЕТАНИИ С БИСФОСФОНАТАМИ И ПРИ МОНОРЕЖИМЕ С ПОМОЩЬЮ ПОЛУКОЛИЧЕСТВЕННОГО АНАЛИЗА ОСТЕОСЦИНТИГРАММESTIMATION OF SAMARIUM-153 OXABIFORE THERAPY RESULTS OF METASTATIC BONE DISEASE IN COMBINED TREATMENT WITH BISPHOSPHONATES AND IN MONO REGIME BY SEMI-QUANTITATIVE ANALYZE OF WB BONE SCANSРасуловаН. В.RasulovaN. V.

зав. отделением радиоизотопной диагностической лаборатории РСЦХ им.акад. В.Вахидова

niga_r@mail.ruАрыбжановД. Т.ArybzhanovD. T.

зав.отделением химиотерапии и эндоваскулярной онкологии Южно - Казахстанского Онкологического диспансера

davran_a@mail.ruЛюбшинВ. И.LyubshinV. I.

зав.клинической онкологией частной клиники “Vega-Med”

kot182@mail.ruКаррэрР.KarrerR.

студент Технического Университета Вены

karrer.rafael@gmail.comБартлА.BartlA.

научный сотрудник Технического Университета Мюниха

Andreas.bartl@tum.deВлодарчикШ.WlodarczykSz.

студент Варшавского Технологического Университета

wlodarczyk.szymon@gmail.comКрыловВ. В.KrylovV. V.

зав. отделением радионуклидной терапии ФГБУ Медицинский радиологический научный центр Минздрава России

krylov@mrrc.obninsk.ruХоджибековМ. Х.KhodjibekovM. Kh.

руководитель рентген-радиологического отдела РСЦХ им. акад. В.Вахидова,

marat.khodjibekov@gmail.comРеспубликанский Специализированный Центр Хирургии им. акад. В.Вахидова, отделение радиоизотопной диагностической лаборатории, г. Ташкент, УзбекистанРоссияRepublic Specialized Center of Surgery, Nuclear Medicine DepartmentRussian Federation20142401201701-23238Copyright © Расулова Н.В., Арыбжанов Д.Т., Любшин В.И., Каррэр Р., Бартл А., Влодарчик Ш., Крылов В.В., Ходжибеков М.Х., 20172017Расулова Н.В., Арыбжанов Д.Т., Любшин В.И., Каррэр Р., Бартл А., Влодарчик Ш., Крылов В.В., Ходжибеков М.Х.Rasulova N.V., Arybzhanov D.T., Lyubshin V.I., Karrer R., Bartl A., Wlodarczyk S., Krylov V.V., Khodjibekov M.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/11

Оценены результаты лечения 54 пациентов: 43 женщин с раком молочной железы и 11 мужчин с раком простаты с метастазами в кости скелета, получившим радионуклидную терапию самарием-153 оксабифором. Согласно проведенному полуколичественному анализу остеосцинтиграмм, наиболее эффективной оказалась комбинированная терапия костных метастазов, где у 84,2% больных отмечалась регрессия костных метастазов, у 7,8% - прогрессия, у такого же числа больных было отмечено одновременно два процесса – прогрессия и регрессия, в то время как у больных, получавших терапию в монорежиме, регрессия отмечалась у 68%, прогрессия – у 25% пациентов, у 6,25% пациентов - стабилизация процесса.

Results of treatment of 54 patients: 43 female with breast cancer and 11 males with prostatic cancer with metastatic bone disease treated with using Sm-153 are assessed. According to semi-quantitative analyze of WB bone scans the most effects results were found in a group of patients who received combined therapy and there where regression of osteoblastic bone metastases in 84,2% of cases, progression is in 7,8%, the same number of patients had simultaneous process: progression and regression. However in patients who were treated with using Sm-153 oxabifore as mono therapy regression of bone metastases was found in 68% of cases, progression is in 25% of the patients and stabilization of metastatic bone disease is in 6,25% of cases.

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The authors declare that there are no conflicts of interest present.