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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2025-15-4-415-424</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-1154</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Получение функциональных гидроксиапатитных покрытий на имплантах с использованием холодного газодинамического напыления</article-title><trans-title-group xml:lang="en"><trans-title>Functional Hydroxyapatite Coating of Implants Using Cold Spraying</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1273-9430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Билялов</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Bilyalov</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Билялов Азат Ринатович — к.м.н., доцент, кафедра травматологии и ортопедии</p><p>Республика Башкортостан, Уфа </p></bio><bio xml:lang="en"><p>Azat R. Bilyalov — Cand. Sci. (Med.), Assoc. Prof., Department of Traumatology and Orthopedics</p><p>Ufa </p></bio><email xlink:type="simple">azat.bilyalov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3352-5255</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бикмеев</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Bikmeev</surname><given-names>A. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бикмеев Александр Тимерзянович — к.ф.-м.н., доцент, старший научный сотрудник, лаборатория математического моделирования</p><p>Республика Башкортостан, Уфа </p></bio><bio xml:lang="en"><p>Alexandr T. Bikmeev — Cand. Sci. (Phys. and Math.), Assoc. Prof., Senior Researcher, Laboratory of Mathematical Simulation</p><p>Ufa </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4772-2302</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахатов</surname><given-names>И. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhatov</surname><given-names>I. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахатов Искандер Шаукатович — д.ф.-м.н., профессор, главный научный сотрудник, лаборатория математического моделирования</p><p>Республика Башкортостан, Уфа </p></bio><bio xml:lang="en"><p>Iskander Sh. Akhatov — Dr. Sci. (Phys. and Math.), Prof., Chief Researcher, Laboratory of Mathematical Simulation</p><p>Ufa </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0256-0645</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джуринский</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhurinskiy</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джуринский Дмитрий Викторович — к.т.н., доцент, старший научный сотрудник, лаборатория математического моделирования</p><p>Республика Башкортостан, Уфа </p></bio><bio xml:lang="en"><p>Dmitry V. Dzhurinskiy — Cand. Sci. (Engineering), Assoc. Prof., Senior Researcher, Laboratory of Mathematical Simulation</p><p>Ufa </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-1559-1456</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юровских</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yurovskikh</surname><given-names>R. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юровских Роман Сергеевич — лаборатория математического моделирования</p><p>Республика Башкортостан, Уфа </p></bio><bio xml:lang="en"><p>Roman S. Yurovskikh — Laboratory of Mathematical Simulation</p><p>Ufa </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1733-9823</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минасов</surname><given-names>Б. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Minasov</surname><given-names>B. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минасов Булат Шамильевич — д.м.н., профессор, кафедра травматологии и ортопедии</p><p>Республика Башкортостан, Уфа </p></bio><bio xml:lang="en"><p>Bulat Sh. Minasov — Dr. Sci. (Med.), Prof., Department of Traumatology and Orthopedics</p><p>Ufa </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-7070-217X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акбашев</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Akbashev</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Акбашев Владислав Николаевич — кафедра травматологии и ортопедии</p><p>Республика Башкортостан, Уфа </p></bio><bio xml:lang="en"><p>Vladislav N. Akbashev — Department of Traumatology and Orthopedics</p><p>Ufa </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4284-5696</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галаутдинов</surname><given-names>М. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Galautdinov</surname><given-names>M. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галаутдинов Марс Фларитович — лаборатория аддитивных технологий</p><p>Республика Башкортостан, Уфа </p></bio><bio xml:lang="en"><p>Mars F. Galautdinov — Laboratory of Additive Technologies</p><p>Ufa </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2025</year></pub-date><volume>15</volume><issue>4</issue><fpage>415</fpage><lpage>424</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Билялов А.Р., Бикмеев А.Т., Ахатов И.Ш., Джуринский Д.В., Юровских Р.С., Минасов Б.Ш., Акбашев В.Н., Галаутдинов М.Ф., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Билялов А.Р., Бикмеев А.Т., Ахатов И.Ш., Джуринский Д.В., Юровских Р.С., Минасов Б.Ш., Акбашев В.Н., Галаутдинов М.Ф.</copyright-holder><copyright-holder xml:lang="en">Bilyalov A.R., Bikmeev A.T., Akhatov I.S., Dzhurinskiy D.V., Yurovskikh R.S., Minasov B.S., Akbashev V.N., Galautdinov M.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/1154">https://www.surgonco.ru/jour/article/view/1154</self-uri><abstract><p>Минимизация риска развития послеоперационных осложнений напрямую зависит от уровня биосовместимости имплантационных систем, что в наибольшей степени определяется состоянием и свойствами их поверхности. Покрытия на основе гидроксиапатита (ГАП) характеризуются структурно-функциональными особенностями, максимально приближенными к характеристикам костной ткани, что обусловливает их широкое применение в биомедицинской инженерии. Следовательно, нанесение гидроксиапатита в качестве модифицирующего покрытия поверхности способно существенно повысить биосовместимость имплантатов и активировать процессы остеоинтеграции. На сегодняшний день формирование тонких покрытий ГАП преимущественно осуществляется методами термического напыления, реализуемыми при температурах, близких к температуре плавления исходного материала. Однако воздействие высоких температур приводит к снижению биосовместимости конечного покрытия и ограничивает возможность введения в его состав термолабильных биоактивных добавок. В связи с этим технологии холодного напыления представляют собой перспективное направление, потенциально превосходящее классические термические методы. Тем не менее высокая хрупкость гидроксиапатита существенно осложняет получение прочных и равномерных покрытий при низкотемпературной обработке. Таким образом, выбор оптимального технологического подхода и установление рациональных параметров напыления являются ключевыми условиями формирования покрытий, обладающих требуемыми физико-химическими характеристиками, обеспечивающими повышение эффективности остеоинтеграции. В настоящей работе представлен систематический анализ экспериментальных исследований, направленных на разработку концептуальных основ подбора параметров порошка, подложки и холодного газодинамического напыления, ориентированных на получение высококачественных гидроксиапатитовых покрытий с улучшенными биомедицинскими свойствами.</p></abstract><trans-abstract xml:lang="en"><p>The risk of developing postoperative complications directly depends on the biocompatibility of implant systems, which is largely determined by the condition and properties of their surface. Hydroxyapatite (HA) coatings are characterized by maximum similarity of structural and functional properties to those of bone tissue, which determines their wide application in biomedical engineering. Therefore, HA as a modifying surface coating can significantly increase the biocompatibility of implants and activate osseointegration processes. Today, thin HA coatings are mainly applied using thermal spraying methods at temperatures close to the melting point of the original material. However, exposure to high temperatures decreases the biocompatibility of the final coating and limits the introduction of heat-labile bioactive additives into its composition. In this regard, cold spraying technologies represent a promising direction, potentially superior to standard thermal methods. However, high brittleness of HA significantly complicates the low-temperature application of strong and uniform coatings. Thus, the selection of an optimal technological approach and establishment of rational spraying parameters represent key conditions for the formation of coatings with the required physicochemical characteristics increasing the efficiency of osseointegration. This paper presents a systematic analysis of experimental studies aimed at developing a conceptual framework for selecting powder, substrate and cold spraying parameters aimed at obtaining high-quality HA coatings with improved biomedical properties.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>холодное газодинамическое напыление</kwd><kwd>импланты</kwd><kwd>покрытия</kwd><kwd>гидроксиапатит</kwd><kwd>костный аллографт</kwd><kwd>биосовместимые материалы</kwd><kwd>костная ткань</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cold spraying</kwd><kwd>implants</kwd><kwd>coatings</kwd><kwd>hydroxyapatite</kwd><kwd>bone allograft</kwd><kwd>biocompatible materials</kwd><kwd>bone tissue</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Данная работа выполнена в рамках приоритетного прикладного научного исследования, выполняемого в рамках государственного задания Минздрава России. Номер государственного учета в ЕГИСУ НИОКТР -124121700079-8.</funding-statement><funding-statement xml:lang="en">The work was carried out as part of a priority applied scientific research project carried out within the framework of a state assignment from the Russian Ministry of Health. State registration number in EGISU NIOKTR — 124121700079-8.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Joint Replacement Surgery. 2024. [cited 2024 Dec 1]. Available from https://rheumatology.org/patients/jointreplacementsurger</mixed-citation><mixed-citation xml:lang="en">Joint Replacement Surgery. 2024. [cited 2024 Dec 1]. 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