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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2026-16-2-198-203</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-1219</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Тотальная панкреатодуоденэктомия: клинические случаи</article-title><trans-title-group xml:lang="en"><trans-title>Total Pancreatoduodenectomy: Clinical Cases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8673-0554</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нартайлаков</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nartailakov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нартайлаков Мажит Ахметович — д.м.н., профессор, кафедра общей хирургии, трансплантологии и лучевой диагностики</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Mazhit A. Nartailakov — Dr. Sci. (Med.), Prof.,  Department of General Surgery, Transplantology and X-ray Diagnostics</p><p>Ufa</p><p> </p></bio><email xlink:type="simple">nart-m@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Золотухин</surname><given-names>К. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zolotukhin</surname><given-names>K. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Золотухин Константин Николаевич — к.м.н., доцент, отделение анестезиологии и реаниматологии</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Konstantin N. Zolotukhin — Cand. Sci. (Med.), Assoc. Prof., Anaesthesiology and lntensive Care Unit</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5694-3257</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салимгареев</surname><given-names>И. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Salimgareev</surname><given-names>I. Z.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Салимгареев Ильдар Зуфарович — к.м.н., хирургическое отделение № 1</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Ildar Z. Salimgareev — Cand. Sci. (Med.), Surgery Unit No. 1</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-4962-872X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванов Иван Иванович — хирургическое отделение № 1</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Ivan I. Ivanov — Surgery Unit No. 1</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0919-3529</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мирасова</surname><given-names>Г. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Mirasova</surname><given-names>G. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мирасова Гульдар Хасановна — отделение анестезиологии и реаниматологии № 1</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Guldar Kh. Mirasova — Anaesthesiology and lntensive Care Unit</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2911-2211</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухубуллин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhubullin</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мухубуллин Ансар Маратович — хирургическое отделение № 1</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Ansar M. Mukhubullin — Surgery Unit No. 1</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8338-2766</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нагаев</surname><given-names>Ф. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Nagaev</surname><given-names>F. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нагаев Фарит Робертович — хирургическое отделение, кафедра общей хирургии, трансплантологии и лучевой диагностики</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Farit R. Nagaev — Surgery Unit, Department of General Surgery, Transplantology and X-ray Diagnostics</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-8570-3643</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сохибназаров</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sohibnazarov</surname><given-names>J. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сохибназаров Джахонгир Нурмамадович — отделение трансплантологии</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Jahongir N. Sohibnazarov — Transplant Unit</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Республиканская клиническая больница им. Г.Г. Куватова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>G.G. Kuvatov Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет; Клиника Башкирского государственного медицинского университета, Башкирский&#13;
государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University; Clinic of Bashkir State Medical University, Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>03</day><month>07</month><year>2026</year></pub-date><volume>16</volume><issue>2</issue><fpage>198</fpage><lpage>203</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нартайлаков М.А., Золотухин К.Н., Салимгареев И.З., Иванов И.И., Мирасова Г.Х., Мухубуллин А.М., Нагаев Ф.Р., Сохибназаров Д.Н., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Нартайлаков М.А., Золотухин К.Н., Салимгареев И.З., Иванов И.И., Мирасова Г.Х., Мухубуллин А.М., Нагаев Ф.Р., Сохибназаров Д.Н.</copyright-holder><copyright-holder xml:lang="en">Nartailakov M.A., Zolotukhin K.N., Salimgareev I.Z., Ivanov I.I., Mirasova G.K., Mukhubullin A.M., Nagaev F.R., Sohibnazarov J.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/1219">https://www.surgonco.ru/jour/article/view/1219</self-uri><abstract><sec><title>Введение</title><p>Введение. Одним из  самых сложных (в  техническом аспекте и  в  плане периоперационного ведения больных) оперативных вмешательств в  абдоминальной хирургии является тотальная панкреатодуоденэктомия. Панкреатодуоденэктомия вместо традиционной панкреатодуоденальной резекции выполняется вынужденно, при внутрипротоковом раке поджелудочной железы с  тотальным ее поражением. Цель  — определение особенностей техники операции и  периоперационного ведения больных после тотальной панкреатодуоденэктомии.</p></sec><sec><title>Материал и  методы</title><p>Материал и  методы. В 1‑м хирургическом отделении РКБ им. Г.Г. Куватова в период с 2019 года по настоящее время выполнены 99  операций по  поводу рака поджелудочной железы, в  том числе дистальных (корпорокаудальных) резекций — 14, панкреатодуоденальных резекций — 78 и тотальных панкреатодуоденэктомий  — 7. Всем семи больным тотальная панкреатодуоденэктомия выполнена по  поводу протоковой аденокарциномы, осложненной механической желтухой. Первым этапом было выполнено рентгенэндобилиарное наружное дренирование желчных протоков. В ходе операции для поддержания гемодинамики проводили гемотрансфузию, переливание плазмы, кристаллоидов. Уровень гликемии контролировали через каждые 60 мин и в ходе операции поддерживали на уровне от 6,0 до 10,0 мкмоль/л введением инсулина короткого действия.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. Продолжительность тотальной панкреатодуоденэктомии достоверно (р &lt; 0,05) была больше, чем при классической панкреатодуоденальной резекции, несмотря на уменьшение количества соустий. Объем кровопотери был примерно таким же, как при панкреатодуоденальной резекции. В раннем послеоперационном периоде умерла 1 пациентка 73 лет от острого инфаркта миокарда. В поздние сроки умерли 4 пациента, двое наблюдаются 14 и 4 месяца без признаков прогрессирования, медиана выживаемости составила 14,2  месяца.</p></sec><sec><title>Заключение</title><p>Заключение. Тотальная панкреатодуоденэктомия, выполняемая вынужденно при протоковом раке ПЖ с субтотальным или тотальным поражением железы, является травматичной по объему и последствиям операцией. В то же время уровень развития хирургической техники, анестезиологии и реаниматологии позволяет рекомендовать выполнение данных вмешательств в специализированных центрах.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Total pancreatoduodenectomy is among the most technically demanding procedures in abdominal surgery, both in terms of operative complexity and perioperative management. It is performed as a necessary alternative to standard pancreatoduodenal resection in cases of intraductal pancreatic cancer with diffuse gland involvement. Aim. This study describes the technical features and perioperative management of patients undergoing total pancreatoduodenectomy.</p></sec><sec><title>Material and methods</title><p>Material and methods. From 2019 to the present, 99 operations for pancreatic cancer were performed in the First Surgical Department of the Republican Clinical Hospital named after G.G. Kuvatov. These included 14 distal (corporal-caudal) pancreatectomies, 78 pancreatoduodenal resections, and 7 total pancreatoduodenectomies. All seven total pancreatoduodenectomies were performed for pancreatic ductal adenocarcinoma complicated by obstructive jaundice. The initial stage involved percutaneous transhepatic external biliary drainage. Intraoperatively, hemodynamic stability was maintained through transfusion of packed red blood cells, plasma, and crystalloids. Blood glucose was monitored every 60 minutes and maintained between 6.0 and 10.0 mmol/L using short-acting insulin.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. The duration of total pancreatoduodenectomy was significantly longer than that of standard pancreatoduodenal resection (p &lt; 0.05), despite fewer anastomoses. Estimated blood loss was comparable between procedures. One 73-yearold patient died in the early postoperative period due to an acute myocardial infarction. Four patients died during long-term follow-up; two remain under observation at 14 and 4 months without evidence of disease progression. Median survival was 14.2 months. Total pancreatoduodenectomy, performed as a necessary measure in ductal pancreatic cancer with subtotal or total gland involvement, remains a highly traumatic procedure. Nevertheless, advances in surgical technique, anesthesiology, and critical care support justify its use in specialized centers.</p></sec><sec><title>Conclusion</title><p>Conclusion. Total pancreatoduodenectomy is an extensive and high-risk procedure that can be performed safely in specialized institutions with appropriate surgical and perioperative expertise.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рак поджелудочной железы</kwd><kwd>панкреатодуоденальная резекция</kwd><kwd>тотальная панкреатодуоденэктомия</kwd><kwd>карцинома протоков поджелудочной железы</kwd><kwd>анастомоз хирургический</kwd><kwd>послеоперационные осложнения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreatic cancer</kwd><kwd>pancreaticoduodenal resection</kwd><kwd>total pancreatoduodenectomy</kwd><kwd>pancreatic ductal carcinoma</kwd><kwd>surgical anastomosis</kwd><kwd>postoperative complications</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Данная работа не финансировалась.</funding-statement><funding-statement xml:lang="en">This work is not funded.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Witzel O. 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