surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2013-0-3-84-92surgonco-178Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSКЛИНИЧЕСКИЕ ОСОБЕННОСТИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ С ЭКСПРЕССИЕЙ РЕЦЕПТОРОВ СТЕРОИДНЫХ ПОЛОВЫХ ГОРМОНОВ И АМПЛИФИКАЦИЕЙ HER2CLINICAL CHARACTERISTICS OF BREAST CANCER WITH STEROID RECEPTORS EXPRESSION AND HER2 AMPLIFICATIONМоисеенкоФ. В.MoiseenkoF. V.

Моисеенко Федор Владимирович - старший научный сотрудник лаборатории нанобиотехнологий  СПб АУ НОЦНТ РАН.

194021, Санкт-Петербург, ул. Хлопина, д. 8, корпус 3, e-mail: Moiseenkofv@gmail.com

Moiseenkofv@gmail.comСемиглазовВ. Ф.SemiglazovV. F.

Семиглазов Владимир Федорович - руководитель отдела опухолей молочной железы ФГБУ НИИ онкологии имени Н.Н. Петрова Минздрава России

СемиглазоваТ. Ю.SemiglazovaT. Yu.

Семиглазова Татьяна Юрьевна - старший научный сотрудник отдела терапевтической  онкологии ФГБУ НИИ онкологии имени Н.Н. Петрова Минздрава России

БогдановА. А.BogdanovA. A.

Богданов  Алексей Александрович - старший научный сотрудник  лаборатории нанобиотехнолдогий, СПб АУ НОЦНТ РАН.

194021, Санкт-Петербург, ул. Хлопина, д.8, корпус 3

ЕлисеевИ. Е.EliseevI. E.

Елисеев Игорь Евгеньевич - младший научный сотрудник лаборатории нанобиотехнологий  СПб АУ НОЦНТ РАН

ИванцовА. О.IvantsovA. O.

Иванцов Александр  Олегович - врач отделения патоморфологии ФГБУ НИИ онкологии  имени Н.Н. Петрова Минздрава России

КнязевН. А.KnyasevN. А.

Князев Николай Александрович - младший научный сотрудник лаборатории нанобиотехнологий СПб АУ НОЦНТ РАН

ТертеровИ. Н.TerterovI. N.

Тертеров Иван Николаевич - младший научный сотрудник  лаборатории нанобиотехнологий  СПб АУ НОЦНТ РАН

КорневА. А.KornevА. A.

Корнев Антон Анатольевич - младший научный сотрудник  лаборатории нанобиотехнологий  СПб АУ НОЦНТ РАН

ДубинаМ. В.DubinaM. V.

Дубина Михаил Владимирович - руководитель лаборатории нанобиотехнологий   СПб АУ НОЦНТ РАН

Санкт-Петербургский Академический университет научно-образовательный центр нано-технологий Российской академии наукRussian FederationНаучно-исследовательский институт онкологии имени Н.Н. Петрова Минздрава РоссииRussian Federation201302022017038492Copyright © Моисеенко Ф.В., Семиглазов В.Ф., Семиглазова Т.Ю., Богданов А.А., Елисеев И.Е., Иванцов А.О., Князев Н.А., Тертеров И.Н., Корнев А.А., Дубина М.В., 20172017Моисеенко Ф.В., Семиглазов В.Ф., Семиглазова Т.Ю., Богданов А.А., Елисеев И.Е., Иванцов А.О., Князев Н.А., Тертеров И.Н., Корнев А.А., Дубина М.В.Moiseenko F.V., Semiglazov V.F., Semiglazova T.Y., Bogdanov A.A., Eliseev I.E., Ivantsov A.O., Knyasev N.А., Terterov I.N., Kornev А.A., Dubina M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/178

С середины прошлого  века рак молочной железы  принято считать высоко гетерогенной группой опухолей.  Гетерогенность основана на различном клиническом течении заболевания, а также на принципиально различной чувствительности к существующим терапевтическим подходам. В основе  клинических решений о выборе тактики лечения  на настоящий момент лежит сочетание  клинических и патоморфологических прогностических и предиктивных маркеров. Наибольшую роль  среди  морфологических предиктивных маркеров играют рецепторы эстрогенов, прогестерона и  эпидермального фактора роста HER2-neu. При этом клиническая группа, характеризующаяся проявлением всех  трех  маркеров,  характеризуется относительно неблагоприятным прогнозом и невысокой чувствительностью к существующим  лекарственным методам.  Авторам  представляется интересным суммировать имеющиеся данные  о клинических особенностях данного типа опухолей  молочной железы.

Since the  middle of the  previous  century  the  heterogeneity of breast cancer  became absolutely evident. This assumption was historically based on differences in clinical behavior and sensitivity to therapy. Treatment approach nowadays is based  primarily on clinical and morphological prognostic and predictive markers. Among morphologically derived markers the most  important are estrogen and progesterone receptors and HER2. Interestingly that tumors with expression of estrogen receptors and/or progesterone receptors that  showed also hyperexpression or amplification of HER2 have very poor outcome and low sensitivity to  all therapeutic  approaches.  Therefore we  want   to  summarize the  existing  clinical information that  is relevant to this topic.

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The authors declare that there are no conflicts of interest present.