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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2013-0-4-84-91</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-197</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>АДЪЮВАНТНОЕ ЛЕЧЕНИЕ РАКА ЖЕЛУДКА</article-title><trans-title-group xml:lang="en"><trans-title>ADJUVANT TREATMENT OF GASTRIC CANCER</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арыбжанов</surname><given-names>Д. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Arybzhanov</surname><given-names>D. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Арыбжанов Дауранбек Турсункулович - заведующий отделением химиотерапии и эндоваскулярной онкологии  ГККП Южно-Казахстанского областного онкологического  диспансера, кандидат медицинских наук.</p><p>160021, Шымкент,  ул. А. Байтурсынова, б/н, тел. 8 (7252) 22-19-54, e-mail: davran_a@mail.ru</p></bio><bio xml:lang="en"/><email xlink:type="simple">davran_a@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахматуллина</surname><given-names>И. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakhmatullina</surname><given-names>I. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рахматуллина Ирина Робинзоновна - декан лечебного факультета БГМУ, доктор медицинских наук, профессор кафедры  онкологии с курсами онкологии и патологической анатомии БГМУ</p></bio><bio xml:lang="en"><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Южно-Казахстанский областной онкологический диспансер</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>South Kazakhstan Regional Oncology Dispensary</institution><country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Башкирский  государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical  University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>05</day><month>02</month><year>2017</year></pub-date><volume>0</volume><issue>4</issue><fpage>84</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Арыбжанов Д.Т., Рахматуллина И.Р., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Арыбжанов Д.Т., Рахматуллина И.Р.</copyright-holder><copyright-holder xml:lang="en">Arybzhanov D.T., Rakhmatullina I.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/197">https://www.surgonco.ru/jour/article/view/197</self-uri><abstract><p>В статье  проанализированы  результаты рандомизированных  многоцентровых исследований,  посвященных выяснению  роли  адъювантной и неоадъювантной химиотерапии, таргетной  терапии, адъювантного химиолучевого лечения  в улучшении результатов хирургического лечения  рака желудка.</p></abstract><trans-abstract xml:lang="en"><p>The  article  analyzes   the   results   of  a  randomized  multicenter  studies   devoted to elucidate the role of adjuvant and neoadjuvant chemotherapy, targeted therapy, adjuvant chemoradiation therapy in improving the results of surgical treatment of gastric cancer.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак</kwd><kwd>желудок</kwd><kwd>лечение</kwd><kwd>адъювантная химиотерапия</kwd><kwd>таргетная терапия</kwd><kwd>химиолучевая терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gastric  cancer</kwd><kwd>treatment</kwd><kwd>adjuvant  chemotherapy</kwd><kwd>targeted  therapy</kwd><kwd>chemoradiation therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bang Y., Kim Y.W., Yang H. et al. Adjuvant capecitabine and oxaliplatin for gastric cancer: results of the phase III CLASSIC trial. 2011 ASCO Annual Meeting // J Clin Oncol. – 2011. – Vol. 29.</mixed-citation><mixed-citation xml:lang="en">Bang Y., Kim Y.W., Yang H. et al. Adjuvant capecitabine and oxaliplatin for gastric cancer: results of the phase III CLASSIC trial. 2011 ASCO Annual Meeting // J Clin Oncol. – 2011. – Vol. 29.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bang Y.J., Kim Y.W., Yang H.K. et al Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial // Lancet. – 2012.</mixed-citation><mixed-citation xml:lang="en">Bang Y.J., Kim Y.W., Yang H.K. et al Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial // Lancet. – 2012.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bang Y.J., Van Cutsem E., Feyereislova A. et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial // Lancet. – 2010. – Vol. 376. – P. 687-697.</mixed-citation><mixed-citation xml:lang="en">Bang Y.J., Van Cutsem E., Feyereislova A. et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial // Lancet. – 2010. – Vol. 376. – P. 687-697.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Chen S., Feng X., Li Y. et al. Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy // Oncol Lett. – 2012. – Vol. 3. – №4. – P. 781-786.</mixed-citation><mixed-citation xml:lang="en">Chen S., Feng X., Li Y. et al. Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy // Oncol Lett. – 2012. – Vol. 3. – №4. – P. 781-786.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chin J. A phase II study of preoperative chemotherapy with modified FOLFOX6 followed by surgery and postoperative chemoradiation in patients with localized gastric adenocarcinoma / Chen S.S., Yang X.C., Chi F., Yu W.Z., Wang Z.B., Ning F.L., Yu Z.S., Hao Y.Z., Li M.L., Wang F., Geng D.Z., Liu L.H., Dong X.J., Peng X.Z., Ji C.X. // Cancer Res. – 2013. – Vol. 25. – №4. – P. 479-481.</mixed-citation><mixed-citation xml:lang="en">Chin J. A phase II study of preoperative chemotherapy with modified FOLFOX6 followed by surgery and postoperative chemoradiation in patients with localized gastric adenocarcinoma / Chen S.S., Yang X.C., Chi F., Yu W.Z., Wang Z.B., Ning F.L., Yu Z.S., Hao Y.Z., Li M.L., Wang F., Geng D.Z., Liu L.H., Dong X.J., Peng X.Z., Ji C.X. // Cancer Res. – 2013. – Vol. 25. – №4. – P. 479-481.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chung M.J., Kim H., Jung Y.S., Shin S.K., Hyung W.J., Noh S.H., Seong J., Lee Y.C., Song S.Y. A pilot study for preoperative concurrent chemoradiotherapy with S-1 and cisplatin for locally advanced gastric cancer // Hepatogastroenterology. – 2013. – Vol. 60. – №122. – P. 382-386.</mixed-citation><mixed-citation xml:lang="en">Chung M.J., Kim H., Jung Y.S., Shin S.K., Hyung W.J., Noh S.H., Seong J., Lee Y.C., Song S.Y. A pilot study for preoperative concurrent chemoradiotherapy with S-1 and cisplatin for locally advanced gastric cancer // Hepatogastroenterology. – 2013. – Vol. 60. – №122. – P. 382-386.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cirera L., Balil A., Batiste-Alentorn E. et al. Randomized clinical trial of adjuvant mitomycin plus tegafur in patients with resected stage III gastric cancer // J Clin Oncol. – 1999. – Vol. 17. – №12. – P. 3810-3815.</mixed-citation><mixed-citation xml:lang="en">Cirera L., Balil A., Batiste-Alentorn E. et al. Randomized clinical trial of adjuvant mitomycin plus tegafur in patients with resected stage III gastric cancer // J Clin Oncol. – 1999. – Vol. 17. – №12. – P. 3810-3815.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Coburn N., Seevaratnam R., Paszat L. et al. Optimal Management of Gastric Cancer: Results From an International RAND/UCLA Expert Panel // Ann Surg. – 2013.</mixed-citation><mixed-citation xml:lang="en">Coburn N., Seevaratnam R., Paszat L. et al. Optimal Management of Gastric Cancer: Results From an International RAND/UCLA Expert Panel // Ann Surg. – 2013.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Coombes R.C., Schein P.S., Chilvers C.E. et al. A randomized trial comparing adjuvant fluorouracil, doxorubicin, and mitomycin with no treatment in operable gastric cancer. International Collaborative Cancer Group // J Clin Oncol. – 1990. – Vol. 8. – №8. – P. 1362-1369.</mixed-citation><mixed-citation xml:lang="en">Coombes R.C., Schein P.S., Chilvers C.E. et al. A randomized trial comparing adjuvant fluorouracil, doxorubicin, and mitomycin with no treatment in operable gastric cancer. International Collaborative Cancer Group // J Clin Oncol. – 1990. – Vol. 8. – №8. – P. 1362-1369.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cunningham D., Allum W.H., Stenning S.P. et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer // N Engl J Med. – 2006. – Vol. 355. – №1. – P. 11-20.</mixed-citation><mixed-citation xml:lang="en">Cunningham D., Allum W.H., Stenning S.P. et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer // N Engl J Med. – 2006. – Vol. 355. – №1. – P. 11-20.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Curr Treat Options Oncol. Treatment options for surgically resectable gastric cancer / Rajdev L. // – 2010. – Vol. 11. – №1-2. – P. 14-23.</mixed-citation><mixed-citation xml:lang="en">Curr Treat Options Oncol. Treatment options for surgically resectable gastric cancer / Rajdev L. // – 2010. – Vol. 11. – №1-2. – P. 14-23.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Dikken J.L., van Sandick J.W., Maurits Swellengrebel H.A., et al. Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS) // BMC Cancer. – 2011. – Vol. 2. – №11. – P. 329.</mixed-citation><mixed-citation xml:lang="en">Dikken J.L., van Sandick J.W., Maurits Swellengrebel H.A., et al. Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS) // BMC Cancer. – 2011. – Vol. 2. – №11. – P. 329.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dikken J.L., Jansen E.P., Cats A. et al. Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer // J Clin Oncol. – 2010. – Vol. 28. – №14. – P. 2430-2436.</mixed-citation><mixed-citation xml:lang="en">Dikken J.L., Jansen E.P., Cats A. et al. Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer // J Clin Oncol. – 2010. – Vol. 28. – №14. – P. 2430-2436.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">D'Ugo D., Rausei S., Biondi A., Persiani R. Preoperative treatment and surgery in gastric cancer: friends or foes? // Lancet Oncol. – 2009. – Vol. 10. – №2. – P. 191-195.</mixed-citation><mixed-citation xml:lang="en">D'Ugo D., Rausei S., Biondi A., Persiani R. Preoperative treatment and surgery in gastric cancer: friends or foes? // Lancet Oncol. – 2009. – Vol. 10. – №2. – P. 191-195.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Earle C.C., Maroun J.A. Adjuvant chemotherapy after curative resection for gastric cancer in non-Asian patients: revisiting a meta-analysis of randomised trials // Eur J Cancer. – 1999. – Vol. 35. – №7. – P. 1059-1064.</mixed-citation><mixed-citation xml:lang="en">Earle C.C., Maroun J.A. Adjuvant chemotherapy after curative resection for gastric cancer in non-Asian patients: revisiting a meta-analysis of randomised trials // Eur J Cancer. – 1999. – Vol. 35. – №7. – P. 1059-1064.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gallo A., Cha C. Updates on esophageal and gastric cancers // World J Gastroenterol. – 2006. – Vol. 12. – №957. – P. 3237-3242.</mixed-citation><mixed-citation xml:lang="en">Gallo A., Cha C. Updates on esophageal and gastric cancers // World J Gastroenterol. – 2006. – Vol. 12. – №957. – P. 3237-3242.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group. Paoletti X., Oba K., Burzykowski T., Michiels S., Ohashi Y., Pignon J.P., et al. Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis // JAMA. – 2010. – Vol. 303. – P. 1729-1737.</mixed-citation><mixed-citation xml:lang="en">GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group. Paoletti X., Oba K., Burzykowski T., Michiels S., Ohashi Y., Pignon J.P., et al. Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis // JAMA. – 2010. – Vol. 303. – P. 1729-1737.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">GLOBOCAN 2008. Cancer Incidence and Mortality Worldwide // IARC CancerBase No. 10 [Internet]. Lyon, France International Agency for Research on Cancer. – 2010.</mixed-citation><mixed-citation xml:lang="en">GLOBOCAN 2008. Cancer Incidence and Mortality Worldwide // IARC CancerBase No. 10 [Internet]. Lyon, France International Agency for Research on Cancer. – 2010.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Gunderson L.L. Gastric cancer-patterns of relapse after surgical resection // Semin Radiat Oncol. – 2002. – Vol. 12. – P. 150-161.</mixed-citation><mixed-citation xml:lang="en">Gunderson L.L. Gastric cancer-patterns of relapse after surgical resection // Semin Radiat Oncol. – 2002. – Vol. 12. – P. 150-161.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hallissey M.T., Dunn J.A., Ward L.C., Allum W.H. The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up // Lancet. – 1994. – Vol. 343. – №8909. – P. 1309-1312.</mixed-citation><mixed-citation xml:lang="en">Hallissey M.T., Dunn J.A., Ward L.C., Allum W.H. The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up // Lancet. – 1994. – Vol. 343. – №8909. – P. 1309-1312.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Han D.S., Suh Y.S., Kong S.H. et al. Outcomes of surgery aiming at curative resection in good responder to induction chemotherapy for gastric cancer with distant metastases // J Surg Oncol. – 2013. – Vol. 107. – №5. – P. 511-516.</mixed-citation><mixed-citation xml:lang="en">Han D.S., Suh Y.S., Kong S.H. et al. Outcomes of surgery aiming at curative resection in good responder to induction chemotherapy for gastric cancer with distant metastases // J Surg Oncol. – 2013. – Vol. 107. – №5. – P. 511-516.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hermans J., Bonenkamp J.J., Boon M.C. et al. Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials // J Clin Oncol. – 1993. – Vol. 11. – №8. – P. 1441-1447.</mixed-citation><mixed-citation xml:lang="en">Hermans J., Bonenkamp J.J., Boon M.C. et al. Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials // J Clin Oncol. – 1993. – Vol. 11. – №8. – P. 1441-1447.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hudis C.A. Trastuzumab--mechanism of action and use in clinical practice // N Engl J Med. – 2007. – Vol. 357. – P. 39–51.</mixed-citation><mixed-citation xml:lang="en">Hudis C.A. Trastuzumab--mechanism of action and use in clinical practice // N Engl J Med. – 2007. – Vol. 357. – P. 39–51.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue M., Tsugane S. Epidemiology of gastric cancer in Japan // Postgrad Med J. – 2005. – Vol. 81. – №957. – P. 419-424</mixed-citation><mixed-citation xml:lang="en">Inoue M., Tsugane S. Epidemiology of gastric cancer in Japan // Postgrad Med J. – 2005. – Vol. 81. – №957. – P. 419-424</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Iwasaki Y., Sasako M., Yamamoto S. et al. Gastric Cancer Surgical Study Group of Japan Clinical Oncology Group. Phase II study of preoperative chemotherapy with S-1 and cisplatin followed by gastrectomy for clinically resectable type 4 and large type 3 gastric cancers (JCOG0210) // J Surg Oncol. – 2013. – Vol. 107. – №7. – P. 741-745.</mixed-citation><mixed-citation xml:lang="en">Iwasaki Y., Sasako M., Yamamoto S. et al. Gastric Cancer Surgical Study Group of Japan Clinical Oncology Group. Phase II study of preoperative chemotherapy with S-1 and cisplatin followed by gastrectomy for clinically resectable type 4 and large type 3 gastric cancers (JCOG0210) // J Surg Oncol. – 2013. – Vol. 107. – №7. – P. 741-745.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Janunger K.G., Hafstrom L., Glimelius B. Chemotherapy in gastric cancer: a review and updated meta-analysis // Eur J Surg. – 2002. – Vol. 168. – №11. – P. 597-608.</mixed-citation><mixed-citation xml:lang="en">Janunger K.G., Hafstrom L., Glimelius B. Chemotherapy in gastric cancer: a review and updated meta-analysis // Eur J Surg. – 2002. – Vol. 168. – №11. – P. 597-608.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2010 (ver. 3) // Gastric Cancer. – 2011. – Vol. 14. – P. 113-123.</mixed-citation><mixed-citation xml:lang="en">Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2010 (ver. 3) // Gastric Cancer. – 2011. – Vol. 14. – P. 113-123.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kerkar S.P., Kemp C.D., Duffy A. et al. The GYMSSA trial: a prospective randomized trial comparing gastrectomy, metastasectomy plus systemic therapy versus systemic therapy alone // Trials. – 2009. – Vol. 23. – №10. – Р. 121.</mixed-citation><mixed-citation xml:lang="en">Kerkar S.P., Kemp C.D., Duffy A. et al. The GYMSSA trial: a prospective randomized trial comparing gastrectomy, metastasectomy plus systemic therapy versus systemic therapy alone // Trials. – 2009. – Vol. 23. – №10. – Р. 121.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kodera Y., Ito S., Mochizuki Y. et al. A phase II study of radical surgery followed by postoperative chemotherapy with S-1 for gastric carcinoma with free cancer cells in the peritoneal cavity (CCOG0301 study) // Eur J Surg Oncol. – 2009. – Vol. 35. – №11. – P. 1158-1163.</mixed-citation><mixed-citation xml:lang="en">Kodera Y., Ito S., Mochizuki Y. et al. A phase II study of radical surgery followed by postoperative chemotherapy with S-1 for gastric carcinoma with free cancer cells in the peritoneal cavity (CCOG0301 study) // Eur J Surg Oncol. – 2009. – Vol. 35. – №11. – P. 1158-1163.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Krook J.E., O'Connell M.J., Wieand H.S. et al. A prospective, randomized evaluation of intensivecourse 5-fluorouracil plus doxorubicin as surgical adjuvant chemotherapy for resected gastric cancer // Cancer. – 1991. – Vol. 67. – №10. – P. 2454-2458.</mixed-citation><mixed-citation xml:lang="en">Krook J.E., O'Connell M.J., Wieand H.S. et al. A prospective, randomized evaluation of intensivecourse 5-fluorouracil plus doxorubicin as surgical adjuvant chemotherapy for resected gastric cancer // Cancer. – 1991. – Vol. 67. – №10. – P. 2454-2458.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ku G.Y., Ilson D.H. Esophagogastric cancer: targeted agents // Cancer Treat Rev. – 2010. – Vol. 36. – P. 235-248.</mixed-citation><mixed-citation xml:lang="en">Ku G.Y., Ilson D.H. Esophagogastric cancer: targeted agents // Cancer Treat Rev. – 2010. – Vol. 36. – P. 235-248.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kundel Y., Purim O., Idelevich E. et al. Postoperative chemoradiation for resected gastric cancer--is the Macdonald Regimen Tolerable? a retrospective multi-institutional study // Radiat Oncol. – 2011. – Vol. 29. – №6. – P. 127.</mixed-citation><mixed-citation xml:lang="en">Kundel Y., Purim O., Idelevich E. et al. Postoperative chemoradiation for resected gastric cancer--is the Macdonald Regimen Tolerable? a retrospective multi-institutional study // Radiat Oncol. – 2011. – Vol. 29. – №6. – P. 127.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lei Chen, Ming-Quan Song, Hui-Zhong Lin et al.. Chemotherapy and resection for gastric cancer with synchronous liver metastases // World J Gastroenterol. – 2013. – Vol. 19. – №13. – P. 2097-2103.</mixed-citation><mixed-citation xml:lang="en">Lei Chen, Ming-Quan Song, Hui-Zhong Lin et al.. Chemotherapy and resection for gastric cancer with synchronous liver metastases // World J Gastroenterol. – 2013. – Vol. 19. – №13. – P. 2097-2103.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Leong T., Joon D.L., Willis D. et al. Adjuvant chemoradiation for gastric cancer using epirubicin, cisplatin, and 5-fluorouracil before and after threedimensional conformal radiotherapy with concurrent infusional 5-fluorouracil: a multicenter study of the Trans-Tasman Radiation Oncology Group // Int J Radiat Oncol Biol Phys. – 2011. – Vol. 79. – №3. – P. 690-695.</mixed-citation><mixed-citation xml:lang="en">Leong T., Joon D.L., Willis D. et al. Adjuvant chemoradiation for gastric cancer using epirubicin, cisplatin, and 5-fluorouracil before and after threedimensional conformal radiotherapy with concurrent infusional 5-fluorouracil: a multicenter study of the Trans-Tasman Radiation Oncology Group // Int J Radiat Oncol Biol Phys. – 2011. – Vol. 79. – №3. – P. 690-695.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Lise M., Nitti D., Marchet A. et al. Final results of a phase III clinical trial of adjuvant chemotherapy with the modified fluorouracil, doxorubicin, and mitomycin regimen in resectable gastric cancer // J Clin Oncol. – 1995. – Vol. 13. – №11. – P. 2757-2763.</mixed-citation><mixed-citation xml:lang="en">Lise M., Nitti D., Marchet A. et al. Final results of a phase III clinical trial of adjuvant chemotherapy with the modified fluorouracil, doxorubicin, and mitomycin regimen in resectable gastric cancer // J Clin Oncol. – 1995. – Vol. 13. – №11. – P. 2757-2763.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Macdonald J.S., Benedetti J., Smalley S. et al. Chemoradiation of resected gastric cancer: a 10-year follow-up of the phase III trial INT0116 (SWOG 9008) // J Clin Oncol. – 2009. – Vol. 27.</mixed-citation><mixed-citation xml:lang="en">Macdonald J.S., Benedetti J., Smalley S. et al. Chemoradiation of resected gastric cancer: a 10-year follow-up of the phase III trial INT0116 (SWOG 9008) // J Clin Oncol. – 2009. – Vol. 27.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Macdonald J.S., Smalley S.R., Benedetti J. et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction // N Engl J Med. – 2001. – Vol. 345. – №10. – P. 725-730.</mixed-citation><mixed-citation xml:lang="en">Macdonald J.S., Smalley S.R., Benedetti J. et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction // N Engl J Med. – 2001. – Vol. 345. – №10. – P. 725-730.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Maeda K., Chung Y.S., Ogawa Y. et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma // Cancer. – 1996. – Vol. 77.– P. 858-863.</mixed-citation><mixed-citation xml:lang="en">Maeda K., Chung Y.S., Ogawa Y. et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma // Cancer. – 1996. – Vol. 77.– P. 858-863.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Mari E., Floriani I., Tinazzi A. et al. Ann Oncol. Efficacy of adjuvant chemotherapy after curative resection for gastric cancer: a meta-analysis of published randomised trials // A study of the GISCAD (Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente) – 2000. – Vol. 11. – №7. – P. 837-843.</mixed-citation><mixed-citation xml:lang="en">Mari E., Floriani I., Tinazzi A. et al. Ann Oncol. Efficacy of adjuvant chemotherapy after curative resection for gastric cancer: a meta-analysis of published randomised trials // A study of the GISCAD (Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente) – 2000. – Vol. 11. – №7. – P. 837-843.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Mi D.H., Li Z., Yang K.H., et al. Surgery combined with intraoperative hyperthermic intraperitoneal chemotherapy (IHIC) for gastric cancer: a systematic review and meta-analysis of randomised controlled trials // Int J Hyperthermia. – 2013. – Vol. 29. – №2. – P. 156-167.</mixed-citation><mixed-citation xml:lang="en">Mi D.H., Li Z., Yang K.H., et al. Surgery combined with intraoperative hyperthermic intraperitoneal chemotherapy (IHIC) for gastric cancer: a systematic review and meta-analysis of randomised controlled trials // Int J Hyperthermia. – 2013. – Vol. 29. – №2. – P. 156-167.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Minn A.Y., Hsu A., La T. et al. Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer // Cancer. – 2010. – Vol. 116. – №16. – P. 3943-3952.</mixed-citation><mixed-citation xml:lang="en">Minn A.Y., Hsu A., La T. et al. Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer // Cancer. – 2010. – Vol. 116. – №16. – P. 3943-3952.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Misleh J.G., Santoro P., Strasser J.F., Bennett J.J. Multidisciplinary management of gastric cancer // Surg Oncol Clin N Am. – 2013. – Vol. 22. – №2. – P. 247-264.</mixed-citation><mixed-citation xml:lang="en">Misleh J.G., Santoro P., Strasser J.F., Bennett J.J. Multidisciplinary management of gastric cancer // Surg Oncol Clin N Am. – 2013. – Vol. 22. – №2. – P. 247-264.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Nakajima T., Nashimoto A., Kitamura M., et al. Adjuvant mitomycin and fluorouracil followed by oral uracil plus tegafur in serosa-negative gastric cancer: a randomised trial. Gastric Cancer Surgical Study Group // Lancet. – 1999. – Vol. 354. – №9175. – P. 273-277.</mixed-citation><mixed-citation xml:lang="en">Nakajima T., Nashimoto A., Kitamura M., et al. Adjuvant mitomycin and fluorouracil followed by oral uracil plus tegafur in serosa-negative gastric cancer: a randomised trial. Gastric Cancer Surgical Study Group // Lancet. – 1999. – Vol. 354. – №9175. – P. 273-277.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Neri B., Cini G., Andreoli F. et al. Randomized trial of adjuvant chemotherapy versus control after curative resection for gastric cancer: 5-year follow-up // Br J Cancer. – 2001. – Vol. 84. – №7. – P. 878-880.</mixed-citation><mixed-citation xml:lang="en">Neri B., Cini G., Andreoli F. et al. Randomized trial of adjuvant chemotherapy versus control after curative resection for gastric cancer: 5-year follow-up // Br J Cancer. – 2001. – Vol. 84. – №7. – P. 878-880.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Ning Z., Chen D., Liu A. et al. Efficacy of Chemotherapy Combined with Targeted Arterial Infusion of Verapamil in Patients with Advanced Gastric Cancer // Cell Biochem Biophys. – 2013.</mixed-citation><mixed-citation xml:lang="en">Ning Z., Chen D., Liu A. et al. Efficacy of Chemotherapy Combined with Targeted Arterial Infusion of Verapamil in Patients with Advanced Gastric Cancer // Cell Biochem Biophys. – 2013.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Ohtsu A., Shah M.A., Van Cutsem E. et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study // J Clin Oncol. – 2011. – Vol. 29.– P. 3968-3976.</mixed-citation><mixed-citation xml:lang="en">Ohtsu A., Shah M.A., Van Cutsem E. et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study // J Clin Oncol. – 2011. – Vol. 29.– P. 3968-3976.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Okuyama T., Korenaga D., Edagawa A. et al. Prognostic effects of oral anti-cancer drugs as adjuvant chemotherapy for 2 years after gastric cancer surgery // Surg Today. – 2012. – Vol. 42. – №8. – P. 734-740.</mixed-citation><mixed-citation xml:lang="en">Okuyama T., Korenaga D., Edagawa A. et al. Prognostic effects of oral anti-cancer drugs as adjuvant chemotherapy for 2 years after gastric cancer surgery // Surg Today. – 2012. – Vol. 42. – №8. – P. 734-740.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Orhan O., Eroglu C., Kaplan B. et al. Whole abdominal field versus standard field radiotherapy plus concomitant and adjuvant chemotherapy for patients with locally advanced gastric cancer // J Radiat Res. – 2011. – Vol. 52. – №2. – P. 168-175.</mixed-citation><mixed-citation xml:lang="en">Orhan O., Eroglu C., Kaplan B. et al. Whole abdominal field versus standard field radiotherapy plus concomitant and adjuvant chemotherapy for patients with locally advanced gastric cancer // J Radiat Res. – 2011. – Vol. 52. – №2. – P. 168-175.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Osti M.F., Agolli L., Bracci S. Adjuvant chemoradiation with 5-fluorouracil or capecitabine in patients with gastric cancer after D2 nodal dissection // Anticancer Res. – 2012. – Vol. 32. – №4. – P. 1397-1402.</mixed-citation><mixed-citation xml:lang="en">Osti M.F., Agolli L., Bracci S. Adjuvant chemoradiation with 5-fluorouracil or capecitabine in patients with gastric cancer after D2 nodal dissection // Anticancer Res. – 2012. – Vol. 32. – №4. – P. 1397-1402.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Panzini I., Gianni L., Fattori P.P. et al. Adjuvant chemotherapy in gastric cancer: a meta-analysis of randomized trials and a comparison with previous meta-analyses // Tumori. – 2002. – Vol. 88. – №1. – P. 21-27.</mixed-citation><mixed-citation xml:lang="en">Panzini I., Gianni L., Fattori P.P. et al. Adjuvant chemotherapy in gastric cancer: a meta-analysis of randomized trials and a comparison with previous meta-analyses // Tumori. – 2002. – Vol. 88. – №1. – P. 21-27.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Paoletti X., Oba K., Burzykowski T., Michiels S. et al. Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis // JAMA. – 2010. – Vol. 303. – №17. – P. 1729-1737.</mixed-citation><mixed-citation xml:lang="en">Paoletti X., Oba K., Burzykowski T., Michiels S. et al. Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis // JAMA. – 2010. – Vol. 303. – №17. – P. 1729-1737.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Sakuramoto S., Sasako M., Yamaguchi T., Kinoshita T. et al. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine // N Engl J Med. – 2007. – Vol. 357. – №18. – P. 1810-1820.</mixed-citation><mixed-citation xml:lang="en">Sakuramoto S., Sasako M., Yamaguchi T., Kinoshita T. et al. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine // N Engl J Med. – 2007. – Vol. 357. – №18. – P. 1810-1820.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Sasako M. Principles of surgical treatment for curable gastric cancer // J Clin Oncol. – 2003. – Vol. 21. – P. 274-275.</mixed-citation><mixed-citation xml:lang="en">Sasako M. Principles of surgical treatment for curable gastric cancer // J Clin Oncol. – 2003. – Vol. 21. – P. 274-275.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Sasako M., Kinoshita T., Furukawa H. Five-year results of the randomized phase III trial comparing S-1 monotherapy versus surgery alone for stage II/III gastric cancer patients after curative D2 gastrectomy ACTS-GC study // Ann Oncol. – 2010. – Vol. 21. – №8. – P. 225-249.</mixed-citation><mixed-citation xml:lang="en">Sasako M., Kinoshita T., Furukawa H. Five-year results of the randomized phase III trial comparing S-1 monotherapy versus surgery alone for stage II/III gastric cancer patients after curative D2 gastrectomy ACTS-GC study // Ann Oncol. – 2010. – Vol. 21. – №8. – P. 225-249.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Sasako M., Sakuramoto S., Katai H. et al. Five-Year Outcomes of a Randomized Phase III Trial Comparing Adjuvant Chemotherapy With S-1 Versus Surgery Alone in Stage II or III Gastric Cancer // J Clin Oncol. – 2011. – Vol. 29. – P. 4387-4393.</mixed-citation><mixed-citation xml:lang="en">Sasako M., Sakuramoto S., Katai H. et al. Five-Year Outcomes of a Randomized Phase III Trial Comparing Adjuvant Chemotherapy With S-1 Versus Surgery Alone in Stage II or III Gastric Cancer // J Clin Oncol. – 2011. – Vol. 29. – P. 4387-4393.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz G.K., Winter K., Minsky B.D. et al. Randomized phase II trial evaluating two paclitaxel and cisplatin-containing chemoradiation regimens as adjuvant therapy in resected gastric cancer (RTOG-0114) // J Clin Oncol. – 2009. – Vol. 27. – №12. – P. 1956-1962.</mixed-citation><mixed-citation xml:lang="en">Schwartz G.K., Winter K., Minsky B.D. et al. Randomized phase II trial evaluating two paclitaxel and cisplatin-containing chemoradiation regimens as adjuvant therapy in resected gastric cancer (RTOG-0114) // J Clin Oncol. – 2009. – Vol. 27. – №12. – P. 1956-1962.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Shah M.A., Jhawer M., Ilson D.H. et al. Phase II study of modified docetaxel, cisplatin, and fluorouracil with bevacizumab in patients with metastatic gastroesophageal adenocarcinoma // J Clin Oncol. – 2011. – Vol. 29.– P. 868-874.</mixed-citation><mixed-citation xml:lang="en">Shah M.A., Jhawer M., Ilson D.H. et al. Phase II study of modified docetaxel, cisplatin, and fluorouracil with bevacizumab in patients with metastatic gastroesophageal adenocarcinoma // J Clin Oncol. – 2011. – Vol. 29.– P. 868-874.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Shulman K., Haim N., Wollner M., Bernstein Z. et al. Postoperative chemotherapy in gastric cancer, consisting of etoposide, doxorubicin and cisplatin, followed by radiotherapy with concomitant cisplatin: A feasibility study // Oncol Lett. – 2012. – Vol. 3. – №5. – P. 1154-1158.</mixed-citation><mixed-citation xml:lang="en">Shulman K., Haim N., Wollner M., Bernstein Z. et al. Postoperative chemotherapy in gastric cancer, consisting of etoposide, doxorubicin and cisplatin, followed by radiotherapy with concomitant cisplatin: A feasibility study // Oncol Lett. – 2012. – Vol. 3. – №5. – P. 1154-1158.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Sonnenblick A., Rottenberg Y., Kadouri L., Wygoda M. et al. Long-term outcome of continuous 5-fluorouracil/cisplatin-based chemotherapy followed by chemoradiation in patients with resected gastric cancer // Med Oncol. – 2012. – Vol. 29. – №5. – P. 3035-3038.</mixed-citation><mixed-citation xml:lang="en">Sonnenblick A., Rottenberg Y., Kadouri L., Wygoda M. et al. Long-term outcome of continuous 5-fluorouracil/cisplatin-based chemotherapy followed by chemoradiation in patients with resected gastric cancer // Med Oncol. – 2012. – Vol. 29. – №5. – P. 3035-3038.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Sougioultzis S., Syrios J., Xynos I.D. et al. Palliative gastrectomy and other factors affecting overall survival in stage IV gastric adenocarcinoma patients receiving chemotherapy: a retrospective analysis // Eur J Surg Oncol. – 2011. – Vol. 37. – №4. – P. 312-318.</mixed-citation><mixed-citation xml:lang="en">Sougioultzis S., Syrios J., Xynos I.D. et al. Palliative gastrectomy and other factors affecting overall survival in stage IV gastric adenocarcinoma patients receiving chemotherapy: a retrospective analysis // Eur J Surg Oncol. – 2011. – Vol. 37. – №4. – P. 312-318.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Sun P., Xiang J.B., Chen Z.Y. Meta-analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer // Br J Surg. – 2009. – Vol. 96. – №1. – P. 26-33.</mixed-citation><mixed-citation xml:lang="en">Sun P., Xiang J.B., Chen Z.Y. Meta-analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer // Br J Surg. – 2009. – Vol. 96. – №1. – P. 26-33.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Valentí V., Hernández-Lizoain J.L., Martínez Regueira F. et al. Analysis of postoperative morbidity in patients with gastric adenocarcinoma treated using a protocol of preoperative chemoradiotherapy and surgery // Cir Esp. – 2009. – Vol. 86. – №6. – P. 351-357.</mixed-citation><mixed-citation xml:lang="en">Valentí V., Hernández-Lizoain J.L., Martínez Regueira F. et al. Analysis of postoperative morbidity in patients with gastric adenocarcinoma treated using a protocol of preoperative chemoradiotherapy and surgery // Cir Esp. – 2009. – Vol. 86. – №6. – P. 351-357.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada S., Ritchim P., Charkrabandhu T., Jongraksat W. Combination 5-fluoruracil/cisplatinum versus 5-fluoruracil/leucovorin adjuvant chemotherapy efficacy for R0 gastric resection in locally invasive gastric cancer // J Med Assoc Thai. – 2012. – Vol. 95. – №12. – P. 1517-1523.</mixed-citation><mixed-citation xml:lang="en">Yamada S., Ritchim P., Charkrabandhu T., Jongraksat W. Combination 5-fluoruracil/cisplatinum versus 5-fluoruracil/leucovorin adjuvant chemotherapy efficacy for R0 gastric resection in locally invasive gastric cancer // J Med Assoc Thai. – 2012. – Vol. 95. – №12. – P. 1517-1523.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Ychou M., Boige V., Pignon J.P., et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial // J Clin Oncol. – 2011. – Vol. 29. – №13. – P. 1715-1721.</mixed-citation><mixed-citation xml:lang="en">Ychou M., Boige V., Pignon J.P., et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial // J Clin Oncol. – 2011. – Vol. 29. – №13. – P. 1715-1721.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Yonemura Y., Endou Y., Shinbo M. et al. Safety and efficacy of bidirectional chemotherapy for treatment of patients with peritoneal dissemination from gastric cancer: Selection for cytoreductive surgery // J Surg Oncol. – 2009. – Vol. 15. – №4. – P. 311-316.</mixed-citation><mixed-citation xml:lang="en">Yonemura Y., Endou Y., Shinbo M. et al. Safety and efficacy of bidirectional chemotherapy for treatment of patients with peritoneal dissemination from gastric cancer: Selection for cytoreductive surgery // J Surg Oncol. – 2009. – Vol. 15. – №4. – P. 311-316.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Yoney A., Bati Y., Akboru H., Isikli L., Unsal M. A retrospective comparison of concurrent 5-fluorouracil or oral UFT in postoperative chemoradiation for gastric adenocarcinoma // Cancer Radiother. – 2010. – Vol. 14. – №1. – P. 19-23.</mixed-citation><mixed-citation xml:lang="en">Yoney A., Bati Y., Akboru H., Isikli L., Unsal M. A retrospective comparison of concurrent 5-fluorouracil or oral UFT in postoperative chemoradiation for gastric adenocarcinoma // Cancer Radiother. – 2010. – Vol. 14. – №1. – P. 19-23.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshikawa T., Sasako M., Yamamoto S., Sano T., Imamura H., Fujitani K., Oshita H., Ito S., Kawashima Y., Fukushima N. Phase II study of neoadjuvant chemotherapy and extended surgery for locally advanced gastric cancer // Br J Surg. – 2009. – Vol. 96. – №9. – P.1015-1022.</mixed-citation><mixed-citation xml:lang="en">Yoshikawa T., Sasako M., Yamamoto S., Sano T., Imamura H., Fujitani K., Oshita H., Ito S., Kawashima Y., Fukushima N. Phase II study of neoadjuvant chemotherapy and extended surgery for locally advanced gastric cancer // Br J Surg. – 2009. – Vol. 96. – №9. – P.1015-1022.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Yu C., Yu R., Zhu W., Song Y., Li T. Intensitymodulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery // J Cancer Res Clin Oncol. – 2012. – Vol. 138. – №2. – P. 255-259.</mixed-citation><mixed-citation xml:lang="en">Yu C., Yu R., Zhu W., Song Y., Li T. Intensitymodulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery // J Cancer Res Clin Oncol. – 2012. – Vol. 138. – №2. – P. 255-259.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
