surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2013-0-4-115-119surgonco-203Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSПЕРИТОНЕАЛЬНЫЙ КАНЦЕРОМАТОЗ. ОБЗОР МИРОВОГО ОПЫТАPERITONEAL CARCINOMATOSIS. REVIEW OF WORLD EXPERIENCEСоломенныйС. В.SolomennyS. V.

Соломенный Сергей Владимирович - аспирант кафедры  онкологии с курсами онкологии и патологической анатомии ИПО БГМУ.

450054,   Республика Башкортостан, Уфа, Пр. Октября, д. 73/1, e-mail: solomenny.s@ya.ru

Oncology Chair with  courses of  Oncology and Pathoanatomy, Ufa

solomenny.s@ya.ruМинигазимовР. С.MinigazimovR. S.

Минигазимов Рамиль Султанович - доцент кафедры  анатомии человека БГМУ, кандидат медицинских наук

Oncology Chair with  courses of  Oncology and Pathoanatomy, Ufa

solomenny.s@ya.ruБашкирский государственный медицинский университет; Республиканский клинический онкологический диспансерРоссияBashkir State Medical University; Republican Clinical Oncology DispanseryRussian Federation20130502201704115119Copyright © Соломенный С.В., Минигазимов Р.С., 20172017Соломенный С.В., Минигазимов Р.С.Solomenny S.V., Minigazimov R.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/203

В течение  трех последних десятилетий понимание биологии и механизмов распространения опухолей   с  внутрибрюшинной диссеминацией,  а  также  понимание защитной функции перитонеального плазменного барьера, участвующего  в отграничении распространения опухоли,  выявило концепцию, что ПК это местнораспространенный процесс:  при отсутствии отдаленных метастазов, комбинированные подходы, сочетающие в себе  агрессивную циторедукцию, внутрибрюшинную химиоперфузию и системную химиотерапию в настоящее время считаются перспективными методами лечения  исходя  из имплантационной теории  канцероматоза. Продемонстрированы современные методы лечения  перитонеального канцероматоза при опухолях различной локализации, позволяющие оптимально контролировать местнораспространенный процесс  заболевания.

During  the  last  three  decades, the  understanding of  the  biology  and  pathways of dissemination  of  tumors  with  intraperitoneal spread,  and   the   understanding  of  the protective function  of  the   peritoneal barrier   against  tumoral seeding, has  prompted the  concept that  PC is a loco-regional disease:  in absence of  other  systemic  metastases, multimodal approaches combining  aggressive cytoreductive surgery,  intraperitoneal hyperthermic chemotherapy and  systemic  chemotherapy have  been  proposed and  are actually considered promising methods to improve loco-regional control of the disease, and ultimately  to increase  survival. The aim of this review article is to present the  evidence  on treatment of PC in different tumors, in order to provide patients with a proper  surgical and multidisciplinary treatment focused on optimal control of their locoregional  disease.

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The authors declare that there are no conflicts of interest present.