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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2018-8-2-70-74</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-321</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Инвертированная папиллома на фоне двустороннего полипозного риносинусита с вязким муцином (клинический случай)</article-title><trans-title-group xml:lang="en"><trans-title>Inverted Papilloma against a Background of Bilateral Rhinosinusitis Polyposa with Viscous Mucin (Clinical Case)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пестова</surname><given-names>Р. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Pestova</surname><given-names>R. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры оториноларингологии с курсом ИДПО, 450008, Уфа, ул. Ленина, 3;</p><p>врач-оториноларинголог отделения оториноларингологии, 450005, Уфа, ул. Достоевского, 132</p></bio><bio xml:lang="en"><p>Assistant Lecturer of the Department of Otorhinolaryngology with the Additional Professional Education Course, 3 Lenin str., Ufa, 450008;</p><p>Otorhinolaryngologist of the Department of Otorhinolaryngology, 132 Dostoevskiy str., Ufa, 450005</p></bio><email xlink:type="simple">aisha_prm@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савельева</surname><given-names>Е. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Savel’eva</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., доцент, зав. кафедрой оториноларингологии с курсом ИДПО, </p><p>450008, Уфа, ул. Ленина, 3</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Associate Professor, Head of the Department of Otorhinolaryngology with the Additional Professional Education Course,</p><p>3 Lenin str., Ufa, 450008</p></bio><email xlink:type="simple">surdolog@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Азнабаева</surname><given-names>Л. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Aznabaeva</surname><given-names>L. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры оториноларингологии с курсом ИДПО, 450008, Уфа, ул. Ленина, 3;</p><p>врач клинической лабораторной диагностики, 450005, Уфа, ул. Достоевского, 132</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor of the Department of Otorhinolaryngology with the Course of Additional Professional Education, 3 Lenin str., Ufa, 450008;</p><p>Physician of Clinical Laboratory Diagnostics, 132 Dostoevskiy str., Ufa, 450005</p><p> </p></bio><email xlink:type="simple">aznabaeva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарипов</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharipov</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., зав. отделением оториноларингологии,</p><p>450005, Уфа, ул. Достоевского, 132</p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences, Head of the Department of Otorhinolaryngology,</p><p>132 Dostoevskiy str., Ufa, 450005</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет;&#13;
Республиканская клиническая больница им. Г.Г. Куватова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University;&#13;
G.G. Kuvatov Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Республиканская клиническая больница им. Г.Г. Куватова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>G.G. Kuvatov Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>05</day><month>11</month><year>2018</year></pub-date><volume>8</volume><issue>2</issue><fpage>154</fpage><lpage>158</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пестова Р.М., Савельева Е.Е., Азнабаева Л.Ф., Шарипов Р.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Пестова Р.М., Савельева Е.Е., Азнабаева Л.Ф., Шарипов Р.А.</copyright-holder><copyright-holder xml:lang="en">Pestova R.M., Savel’eva E.E., Aznabaeva L.F., Sharipov R.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/321">https://www.surgonco.ru/jour/article/view/321</self-uri><abstract><sec><title>Введение</title><p>Введение. Полипозный риносинусит — хроническое воспаление слизистой оболочки носа и околоносовых пазух, сопровождающееся рецидивирующим ростом полипов и характеризующееся высокой распространенностью. Назальные полипы могут сопровождаться наличием тягучего муцина, характерными КТ-признаками которых является гиперостоз стенок пораженных пазух, и истончением стенок пазух вплоть до костной деструкции как признак асептического остеомиелита. Такой же признак характерен и для наиболее часто встречаемой доброкачественной опухоли носа и пазух — инвертированной папилломы.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В настоящей статье представлено клиническое наблюдение, интересное тем, что на фоне двустороннего полипозного риносинусита была диагностирована доброкачественная опухоль. В клинической картине не было характерных для инвертированной папилломы носовых кровотечений, что, скорее всего, связано с начальным ростом опухоли; утолщение костных структур (гиперостоз) было симметричным из-за патогенетических особенностей развития полипозного риносинусита с вязким муцином. Подозрения в отношении инвертированной папилломы возникли уже при выполнении риноскопии, которая выявила асимметричный рост полипов. Окончательная верификация клинического диагноза проведена после компьютерной томографии носа и околоносовых пазух и гистологического исследования биопсийного материала.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. Интерес данного клинического случая представляют данные риноцитограмм, которые позволяют предположить вирусную и воспалительную этиологию развития инвертированной папилломы. Так, обнаруженные нуклеолы ядер цилиндрического эпителия являются признаком внутриклеточной инвазии, в частности вирусной, а ремоделирование клеток цилиндрического эпителия является признаком хронического воспалительного процесса.</p></sec><sec><title>Заключение</title><p>Заключение. Таким образом, четкое выполнение диагностического алгоритма с гистологической верификацией всего удаленного материала позволяет выявить новообразование полости носа даже в сложных случаях, в том числе на фоне других заболеваний полости носа. Риноцитограмма может помочь предположить этиологию внутриклеточного типа инфицирования клеточного эпителия и патогенез инвертированной папилломы в конкретном случае.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Rhinosinusitis polyposa consists in a chronic inflammation of the mucous membrane of the nose and paranasal sinuses, followed by recurrent growth of polyps and characterised by a high prevalence. Nasal polyps may be associated with the presence of viscous mucin; their characteristic CT signs are hyperostosis of the walls of the affected sinuses and thinning cavity walls until the bone is destroyed, this being a sign of aseptic osteomyelitis. The same sign is typical for inverted papilloma, the most common benign tumour of the nose and sinuses.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The present article presents a clinical observation. What makes it interesting is that a benign tumour was diagnosed against the background of bilateral rhinosinusitis polyposa. The clinical picture did not have nasal bleeding, which is typical for inverted papilloma; this was most likely due to the initial growth of the tumour. Thickening bone structures (hyperostosis) was balanced due to the pathogenetic peculiarities of the rhinosinusitis polyposa development with viscous mucin. Inverted papilloma was suspected during rhinoscopy, which revealed asymmetric growth of polyps. Final verification of the clinical diagnosis was carried out following computerised tomography of the nose and paranasal sinuses and histological examination of biopsy material.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. This clinical case is of interest due to rhinocytogram data suggesting a viral and inflammatory etiology of the development of inverted papilloma. Therefore, the observed nucleoli of the nuclei of the columnar epithelium are characteristic of intracellular infection — in particular, viral. Remodelling of cells of the cylindrical epithelium is a sign of chronic inflammatory process.</p></sec><sec><title>Conclusion</title><p>Conclusion. Thus, accurate performance of the diagnostic algorithm with histological verification of all removed material allows the identification of a neoplasm of the nasal cavity even in difficult cases, along with other diseases of the nasal cavity. Rhinocytogram data can help suggest the etiology of the intracellular type of infection in the epithelial cell and pathogenesis of inverted papilloma in a particular case.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>решетчатой кости синусит</kwd><kwd>верхнечелюстной синусит</kwd><kwd>носа полипы</kwd><kwd>носа новообразования</kwd><kwd>муцины</kwd><kwd>папиллома переходно-клеточная</kwd><kwd>риноцитограмма</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ethmoid sinusitis</kwd><kwd>maxillary sinusitis</kwd><kwd>nasal polyps</kwd><kwd>nose neoplasms</kwd><kwd>mucins</kwd><kwd>inverted papilloma</kwd><kwd>rhinocytogram</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Пискунов Г.З. Полипозный риносинусит. М.: ГЭОТАР-Медиа, 2016. 96 с.</mixed-citation><mixed-citation xml:lang="en">Piskunov G.Z. Poliposis rhinosinusitis. M.: GEOTAR-Media; 2016. 96 p. 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