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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2018-8-4-279-284</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-347</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Минерализация брюшины — новая мишень в терапии перитонеального канцероматоза</article-title><trans-title-group xml:lang="en"><trans-title>Mineralization of the Peritoneum — a New Target in the Treatment of Peritoneal Carcinomatosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2047-963X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ганцев</surname><given-names>Ш. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Gantsev</surname><given-names>Sh. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ганцев Шамиль Ханафиевич — доктор медицинских наук, профессор, директор НИИ онкологии.</p><p>450008, Уфа, ул. Ленина, 3</p></bio><bio xml:lang="en"><p>Gantsev Shamil Khanafievich — Doctor of Medical Sciences, Professor, Director of the Scientific Research Institute of Oncology.</p></bio><email xlink:type="simple">prfg@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2024-681X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеенко</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseenko</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Моисеенко Владимир Михайлович — доктор медицинских наук, профессор, директор Санкт-Петербургского клинического научно-практического центра специализированных видов медицинской помощи (онкологического).</p><p>197758, Санкт-Петербург, посёлок Песочный, ул. Ленинградская, д. 68а, лит. А</p></bio><bio xml:lang="en"><p>Moiseenko Vladimir Mikhaylovich — Doctor of Medical Sciences, Professor, Director of St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncologic).</p><p>68A Leningradskaya str., St. Petersburg, 197758</p></bio><email xlink:type="simple">moiseyenkov@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7562-5684</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ганцев</surname><given-names>К. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Gantsev</surname><given-names>K. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ганцев Камиль Шамилевич — доктор медицинских наук, профессор, профессор кафедры онкологии с курсами онкологии и патологической анатомии ИДПО.</p></bio><bio xml:lang="en"><p>Gantsev Kamil Shamilevich — Doctor of Medical Sciences, Professor, Professor of the Department of Oncology with Oncology and Anatomical Pathology courses in the Institute of Additional Professional Education.</p><p>3 Lenin str., Ufa, 450006</p></bio><email xlink:type="simple">gantseff@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соломенный</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Solomenny</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соломенный Сергей Владимирович — кандидат медицинских наук, врач-онколог.</p><p>450112, Уфа, ул. Нежинская, 28</p></bio><bio xml:lang="en"><p>Solomenny Sergey Vladimirovich — Candidate of Medical Sciences, Oncologist.</p><p>28 Nezhinskaya str., Ufa, 450112</p></bio><email xlink:type="simple">solomenny.s@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9721-108X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кзыргалин</surname><given-names>Ш. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kzyrgalin</surname><given-names>Sh. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кзыргалин Шамиль Римович — кандидат медицинских наук, доцент кафедры онкологии с курсами онкологии и патологической анатомии ИДПО.</p><p>450008, Уфа, ул. Ленина, 3</p></bio><bio xml:lang="en"><p>Kzyrgalin Shamil Rimovich — Candidate of Medical Sciences, Associate Professor of the Department of Oncology with Oncology and Anatomical Pathology courses in the Institute of Additional Professional Education.</p><p>3 Lenin str., Ufa, 450006</p></bio><email xlink:type="simple">ufa.shamil@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Докичев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dokichev</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Докичев Владимир Анатольевич — доктор химических наук, профессор, заведующий кафедрой  общей химии.</p><p>450008, Уфа, ул. К. Маркса, 12</p></bio><bio xml:lang="en"><p>Dokichev Vladimir Anatolevich — Doctor of Chemical Sciences, Professor, Head of the Department of General Chemistry.</p><p>12 K. Marxa str., Ufa, 450008</p></bio><email xlink:type="simple">chemistry.63@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2544-9042</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеенко</surname><given-names>Ф. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseenko</surname><given-names>F. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Моисеенко Федор Владимирович — доктор медицинских наук, заведующий отделением биотерапии.</p><p>197758, Санкт-Петербург, посёлок Песочный, ул. Ленинградская, д. 68а, лит. А</p></bio><bio xml:lang="en"><p>Moiseenko Fedor Vladimirovich — Doctor of Medical Sciences, Head of the Department of Biotherapy.</p><p>68A Leningradskaya str., St. Petersburg, 197758</p></bio><email xlink:type="simple">moiseenkofv@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минигазимов</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Minigazimov</surname><given-names>R. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минигазимов Рамил Султанович — кандидат медицинских наук, доцент кафедры анатомии человека.</p><p>450008, Уфа, ул. Ленина, 3</p></bio><bio xml:lang="en"><p>Minigazimov Ramil Sultanovich — Candidate of Medical Sciences, Associate Professor of the Department of Anatomy.</p></bio><email xlink:type="simple">anatombsmu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Санкт-Петербургский клинический научно-практический центр специализированных видов медицинской помощи (онкологический)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care (Oncologic)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Городская клиническая больница № 13</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital № 13</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Уфимский государственный авиационный технический университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ufa State Aviation Technical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>21</day><month>03</month><year>2019</year></pub-date><volume>8</volume><issue>4</issue><fpage>279</fpage><lpage>284</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ганцев Ш.Х., Моисеенко В.М., Ганцев К.Ш., Соломенный С.В., Кзыргалин Ш.Р., Докичев В.А., Моисеенко Ф.В., Минигазимов Р.С., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Ганцев Ш.Х., Моисеенко В.М., Ганцев К.Ш., Соломенный С.В., Кзыргалин Ш.Р., Докичев В.А., Моисеенко Ф.В., Минигазимов Р.С.</copyright-holder><copyright-holder xml:lang="en">Gantsev S.K., Moiseenko V.M., Gantsev K.S., Solomenny S.V., Kzyrgalin S.R., Dokichev V.A., Moiseenko F.V., Minigazimov R.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/347">https://www.surgonco.ru/jour/article/view/347</self-uri><abstract><sec><title>Введение</title><p>Введение. В статье представлены данные о проявлениях изменений микросреды брюшинной полости при канцероматозе, выражающихся минерализацией брюшины, что, в свою очередь, приводит к функциональным изменениям в дренировании брюшинной полости.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Сравнительной сканирующей растровой электронной микроскопии подверглись ауто-псийные ткани брюшины с явлениями канцероматоза и интактной брюшины.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. Изучение ультраструктуры брюшины при перитонеальном канцероматозе (ПК) выявило феномен минерализации серозно-лимфатических люков. Полученный профиль элементного состава продемонстрировал повышенное содержание таких элементов, как Ca, P, Na.</p></sec><sec><title>Выводы</title><p>Выводы. 1. Канцероматоз — это не локальный, а системный процесс. Определение роли минерализации при канцероматозе имеет фундаментальное значение в канцерогенезе. 2. Минерализации серозных оболочек при канцероматозе может стать новой терапевтической мишенью, воздействие на которую позволит увеличить продолжительность жизни пациентов и улучшить качество жизни. 3. Деминерализации серозных оболочек может служить компонентом комплексного лечения, включающего последующую эндолимфатическую противоопухолевую лекарственную терапию.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. This article presents data on the manifestations of changes in the microenvironment of the peritoneal cavity in patients with carcinomatosis, expressed by the mineralization of the peritoneum, which in turn leads to functional changes in drainage of the peritoneal cavity.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. We examined autopsy tissue of the peritoneum with symptoms of carcinomatosis and intact peritoneum using comparative scanning electron microscopy.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. The study of the ultrastructure of peritoneum in patients with PC, revealed the phenomenon of SLL mineralization. The resulting elemental composition profile showed a high content of Ca, P, Na.</p></sec><sec><title>Conclusions</title><p>Conclusions. 1. Carcinomatosis is not a local, but rather a systemic process. Determining the role of mineralization in carcinomatosis is of fundamental importance in carcinogenesis. 2. The serous membranes mineralization in patients with carcinomatosis can become a new treatment target, the impact on which may increase life expectancy and improve the quality of life. 3. The serous membranes demineralization can serve as a part of a combination treatment that includes the subsequent endolymphatic anti-tumour drug therapy.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>брюшина</kwd><kwd>канцероматоз</kwd><kwd>минерализация брюшины</kwd><kwd>кальциноз</kwd><kwd>серозно-лимфатический люк</kwd><kwd>деминерализация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>peritoneum</kwd><kwd>carcinomatosis</kwd><kwd>mineralization</kwd><kwd>calcinosis</kwd><kwd>serous lymphatic hatch</kwd><kwd>demineralization</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cabalag C.S., Chan S.T., Kaneko Y., Duong C.P. A systematic review and meta-analysis of gastric cancer treatment in patients with positive peritoneal cytology. Gastric Cancer. 2015;18(1):11—22. 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