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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2019-9-1-26-30</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-360</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Оценка качества жизни пациентов с диффузным токсическим зобом после проведенной тиреоидэктомии</article-title><trans-title-group xml:lang="en"><trans-title>Assessing Quality of Life in Patients with Graves’ Disease Following Thyroidectomy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5787-8269</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стяжкина</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Styazhkina</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Стяжкина Светлана Николаевна — доктор медицинских наук, профессор кафедры факультетской хирургии</p><p>426034, Ижевск, ул. Коммунаров, 281</p></bio><bio xml:lang="en"><p>Styazhkina Svetlana Nikolaevna — Doctor of Medical Sciences, Professor of the Department of Departmental Surgery</p><p>281 Kommunarov srt., Izhevsk, 426034</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3871-6197</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леднева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ledneva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Леднева Анна Викторовна — кандидат медицинских наук, ассистент кафедры факультетской хирургии </p><p>426034, Ижевск, ул. Коммунаров, 281</p></bio><bio xml:lang="en"><p>Ledneva Anna Viktorovna — Candidate of Medical Sciences, Assistant lecturer of the Department of Departmental Surgery</p><p>281 Kommunarov srt., Izhevsk, 426034</p></bio><email xlink:type="simple">AnnaVLed@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0650-5064</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Порываева</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Poryvaeva</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Порываева Екатерина Леонидовна — аспирант кафедры факультетской хирургии, врач-хирург </p><p>426000, Ижевск, Воткинское шоссе, 57</p></bio><bio xml:lang="en"><p>Poryvaeva Ekaterina Leonidovna — Post-graduate student of the Department of Departmental Surgery, Surgeon</p><p> </p><p>57 Votkinskoye Highway, Izhevsk, 426000</p></bio><email xlink:type="simple">asu@rkb1.udm.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ижевская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Izhevsk State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Ижевская государственная медицинская академия;&#13;
Первая республиканская клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Izhevsk State Medical Academy; &#13;
First Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>25</day><month>04</month><year>2019</year></pub-date><volume>9</volume><issue>1</issue><fpage>26</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Стяжкина С.Н., Леднева А.В., Порываева Е.Л., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Стяжкина С.Н., Леднева А.В., Порываева Е.Л.</copyright-holder><copyright-holder xml:lang="en">Styazhkina S.N., Ledneva A.V., Poryvaeva E.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/360">https://www.surgonco.ru/jour/article/view/360</self-uri><abstract><p>Диффузный токсический зоб — заболевание, сопровождающееся гиперпродукцией гормонов щитовидной железы и изменением в связи с этим функционального состояния различных органов и систем. По распространенности среди заболеваний щитовидной железы занимает второе место после эндемического зоба. До настоящего времени нет общего мнения по поводу единой тактики лечения заболеваний щитовидной железы. В этой связи основной целью настоящего исследования является оценка влияния оперативного лечения диффузного токсического зоба на качество жизни пациентов и возможность его улучшения путем сочетания хирургического лечения с послеоперационной заместительной гормональной терапией.</p><sec><title>Материалы иметоды</title><p>Материалы иметоды. Проведен ретроспективный анализ 70 историй болезни оперированных пациентов с диффузным токсическим зобом в БУЗ УР «Первая Республиканская клиническая больница» МЗ УР, г. Ижевск, за период с 2008 по2014 г. Стадии заболевания: 2-я стадия — 20 %, 3-я стадия — 70 %, 4-я стадия — 10 %. Им были произведены резекция доли — 3 %, резекция обеих долей — 1 %, гемитиреоидэктомия — 18 ± 4,6 %, субтотальная резекция — 8 %, тиреоидэктомия — 70 ± 5,5 %.</p></sec><sec><title>Результаты</title><p>Результаты. Процент заболевших послеоперационным гипотиреозом: тяжелая степень — 66 %, средняя степень — 29 %, легкая степень — 5 %, рецидивов ДТЗ не было. Жалобы после тиреоидэктомии: прибавка веса — 79,1 % ± 4,8, зябкость конечностей — 83,3 ± 4,4 %, перебои в работе сердца — 85,2 ± 4,2 %, отеки — 84,3 ± 4,3 %, сонливость, вялость — 67,1 ± 5,6 %, нарушение аппетита — 21 ± 4,8 %, бледность кожных покровов — 47,6 ± 5,9 %, ломкость ногтей, выпадение волос — 51,2 ± 5,9 %, боли в суставах — 31,2 ± 5,53 %.</p></sec><sec><title>Заключение</title><p>Заключение. В результате проведенной тиреоидэктомии всегда возникает гипотиреоз, который требует постоянной заместительной гормональной терапии препаратами L-тироксина. В случае постоянного приема препаратов, индивидуально подобранной дозировки качество жизни не страдает.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Graves’ disease is a disorder associated with thyroid gland producing excessive amounts of hormones which causes changes in the functional status of various organs and systems. Among thyroid disorders it takes the second place (after endemic goitre) in prevalence. Until now, there is no consensus on a single strategy for the treatment of disorders of the thyroid gland. This is why this paper aims to assess the impact of surgical treatment of Graves’ disease on patients’ quality of life and whether it would be possible to improve it by following the surgery with hormone replacement therapy.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. This paper presents a retrospective analysis of 70 case histories of patients who received surgical treatment for diffuse toxic goitre at the BIH UR “First Republican Teaching Hospital” MH UR,Izhevsk, in the period from 2008 to 2014. Percentages of the disease by stage were as follows: stage II — 20%, stage III — 70%, stage 4 — 10%. One lobe resection was performed in 3% of patients, two lobe resection — in 1%, hemithyroidectomy — in 18±4.6%, subtotal resection — in 8%, thyroidectomy — in 70±5.5%.</p></sec><sec><title>Results</title><p>Results. Percentages of patients with various degrees of severity of postoperative hypothyroidism were as follows: severe — 66%, medium — 29%, light — 5%; there were no Graves’ disease recurrences. Patients’ complaints following thyroidectomy included body weight gain — 79.1±4.8%, cold in extremities — 83.3±4.4%, cardiac arrhythmia — 85.2±4.2%, oedemas — 84.3±4.3%, drowsiness, atonia — 67.1±5.6%, changes in appetite — 21±4.8%, skin pallor — 47.6±5.9%, brittle nails, hair loss — 51.2±5.9%, joint pain — 31.2±5.53%.</p></sec><sec><title>Conclusion</title><p>Conclusion. Hypothyroidism always follows thyroidectomy and requires ongoing hormone replacement therapy with L-thyroxine. Th quality of life does not have to suffer if an individual dosage is established and followed on a permanent basis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>диффузный токсический зоб</kwd><kwd>тиреоидэктомия</kwd><kwd>качество жизни</kwd><kwd>гипотиреоз</kwd><kwd>тироксин</kwd><kwd>послеоперационные осложнения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Graves’ disease</kwd><kwd>thyroidectomy</kwd><kwd>quality of life</kwd><kwd>hypothyroidism</kwd><kwd>thyroxine</kwd><kwd>postoperative complications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vital D., Morand G.B., Meerwein C., Laske R.D., Steinert H.C., Schmid C., et al. Early timing of thyroidectomy for hyperthyroidism in Graves’ disease improves biochemical recovery. World J Surg. 2017;41(10):2545–50. 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