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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2019-9-3-209-215</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-417</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Хирургическое лечение хронического остеомиелита</article-title><trans-title-group xml:lang="en"><trans-title>Surgical Treatment of Chronic Osteomyelitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0096-5318</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гараев</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Garaev</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гараев Марат Раилевич — к.м.н., доцент кафедры общей хирургии с курсами трансплантологии и лучевой диагностики ИДПО, хирург отделения гнойной хирургии, тел.: 8 (347) 2729928</p></bio><bio xml:lang="en"><p>Garaev Marat Railevich — Candidate of Medical Sciences, Associate Professor of the Department of General Surgery with Transplantology and Radiological diagnosis courses in the Institute of Additional Professional Education, Surgeon of the Septic Surgery Department, tel.: 8 (347) 2729928</p></bio><email xlink:type="simple">doktormr@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пантелеев</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Panteleev</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пантелеев Владимир Сергеевич — д.м.н., профессор кафедры общей хирургии с курсами трансплантологии и лучевой диагностики ИДПО, зав. отделением лазерной хирургии, тел.: 8 (347) 2287994</p></bio><bio xml:lang="en"><p>Panteleev Vladimir Sergeevich — Doctor of Medical Sciences, Professor of the Department of General Surgery with Transplantology and Radiological diagnosis courses in the Institute of Additional Professional Education, Head of the Laser Surgery Department, tel.: 8 (347) 2287994</p></bio><email xlink:type="simple">w.s.panteleev@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нартайлаков</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nartaylakov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нартайлаков Мажит Ахметович — д.м.н., профессор, зав. кафедрой общей хирургии с курсами трансплантологии и лучевой диагностики ИДПО, хирург, тел.: 8 (347) 2287994</p></bio><bio xml:lang="en"><p>Nartaylakov Mazhit Achmetovich — Doctor of Medical Sciences, Professor, Head of the Department of General Surgery with Transplantology and Radiological diagnosis courses in the Institute of Additional Professional Education, Surgeon, tel.: 8 (347) 2287994</p></bio><email xlink:type="simple">nart-m@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дорофеев</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Dorofeev</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дорофеев Вадим Давидович — к.м.н., зав. отделением гнойной хирургии, тел.: 8(347)2729928</p></bio><bio xml:lang="en"><p>Dorofeev Vadim Davidovich — Candidate of Medical Sciences, Head of the Septic Surgery Department, tel.: 8(347)2729928</p></bio><email xlink:type="simple">dorofeew.v@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Инюшев</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Inyushev</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Инюшев Дмитрий Владимирович — ординатор кафедры общей хирургии с курсами трансплантологии и лучевой диагностики ИДПО, тел.: 8 (347) 2287994</p></bio><bio xml:lang="en"><p>Inyushev Dmitriy Vladimirovich — Resident of the Department of General Surgery with Transplantology and Radiological diagnosis courses in the Institute of Additional Professional Education, tel.: 8 (347) 2287994</p></bio><email xlink:type="simple">dima.608@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голков</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Golkov</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голков Дмитрий Сергеевич — ординатор кафедры общей хирургии с курсами трансплантологии и лучевой диагностики ИДПО, тел.: 8 (347) 2287994</p></bio><bio xml:lang="en"><p>Golkov Dmitriy Sergeevich — Resident of the Department of General Surgery with Transplantology and Radiological diagnosis courses in the Institute of Additional Professional Education, tel.: 8 (347) 2287994</p></bio><email xlink:type="simple">Md_golkov@icloud.com</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканская клиническая больница им. Г.Г. Куватоваф; &#13;
Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>G.G. Kuvatov Republican Clinical Hospital; &#13;
Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Республиканская клиническая больница им. Г.Г. Куватова; &#13;
Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>G.G. Kuvatov Republican Clinical Hospital; &#13;
Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Республиканская клиническая больница им. Г.Г. Куватова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>G.G. Kuvatov Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2019</year></pub-date><volume>9</volume><issue>3</issue><fpage>209</fpage><lpage>215</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гараев М.Р., Пантелеев В.С., Нартайлаков М.А., Дорофеев В.Д., Инюшев Д.В., Голков Д.С., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Гараев М.Р., Пантелеев В.С., Нартайлаков М.А., Дорофеев В.Д., Инюшев Д.В., Голков Д.С.</copyright-holder><copyright-holder xml:lang="en">Garaev M.R., Panteleev V.S., Nartaylakov M.A., Dorofeev V.D., Inyushev D.V., Golkov D.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/417">https://www.surgonco.ru/jour/article/view/417</self-uri><abstract><sec><title>Введение</title><p>Введение. Основной целью данного исследования послужила оценка собственных результатов применения различных методов хирургического лечения в комплексном лечении воспалительных заболеваний костей и суставов.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В работу вошли данные разнонаправленного когортного исследования с непараллельным (историческим) контролем. Ретроспективное исследование включало анализ историй болезней в период с 2009 по 2016 г. (1059 пациентов), проспективное исследование заключалось в анализе эффективности современных методов хирургического лечения в комплексном лечении гнойных заболеваний костей и суставов у пациентов, госпитализированных в отделение гнойной хирургии РКБ им. Г.Г. Куватова (г. Уфа) в период 2017–2018 гг. (285 пациентов).</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. В результате анализа собственного материала выявлено, что наиболее частыми причинами развития остеомиелитов являются травмы (73,21 %) и инфекционные осложнения после операций на костях и суставах (15,03 %). Комплекс диагностических мероприятий при подозрении на остеомиелитический процесс, включающий в себя рентгенологическое исследование, общеклинические анализы, дополненные фистулографией или КТ пораженной области до операции и исследованием операционного материала после операции, оптимален для диагностики остеомиелитов различной этиологии в большинстве случаев. Применение современных методов хирургической обработки и пластики костных дефектов в комплексном лечении пациентов с хроническими остеомиелитами позволяет достоверно уменьшить частоту рецидива заболевания. Лечение пациентов с остеомиелитами предпочтительнее осуществлять в крупных хирургических стационарах, имеющих в своем составе специализированное хирургическое отделение для лечения хирургических инфекций и соответствующие вспомогательные службы.</p></sec><sec><title>Заключение</title><p>Заключение. Однозначно лучшего метода лечения остеомиелитов, на наш взгляд, не существует. Оптимальный эффект при лечении остеомиелитов достигается при применении индивидуально подобранного набора лечебных мероприятий с применением таких методов, как лазерная вапоризация, вакуумная терапия ран, ультразвуковая кавитация в воспалительном очаге, пластика посттрепанационного дефекта кости или раны.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. In this study, we analysed the results of applying various surgical methods in the combined treatment of inflammatory diseases of bones and joints.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The work was based on data from a multi-dimensional cohort study using non-concurrent (historical) control. A retrospective study included the analysis of medical records covering the period of 2009–2016 (1059 patients). A prospective study consisted in analysing the effectiveness of modern surgical methods in the combined treatment of inflammatory diseases of bones and joints in patients hospitalised to the Septic Surgery Department of the G.G. Kuvatov Republican Clinical Hospital (Ufa, Russia) in 2017–2018 (285 patients).</p></sec><sec><title>Results and discussion</title><p>Results and discussion. An analysis of the authors’ own data revealed that injuries (73.21%) and infectious complications after receiving surgery on bones and joints (15.03%) are the most common causes of osteomyelitis. In most cases, the following list of measures is optimal for diagnosing suspected osteomyelitis of various etiologies: X-ray, general clinical tests supplemented by the fistulography or CT of the affected area prior to surgery, as well as the examination of surgical material after surgery. The use of modern methods for surgical debridement and surgical repair of bone defects in the combined treatment of patients with chronic osteomyelitis can significantly reduce the relapse rate. It is recommended that patients with osteomyelitis be treated at large in-patient surgical facilities, which include a specialised department for the treatment of surgical infections and corresponding support services.</p></sec><sec><title>Conclusion</title><p>Conclusion. Apparently, there is no one most optimal method for treating osteomyelitis. The optimal effect in the treatment of osteomyelitis is achieved through a personalised set of therapeutic measures using the following methods: laser vaporisation, negative-pressure wound therapy, ultrasonic cavitation in the focus of inflammation, as well as surgical repair of the post-trepanation bone defect or wound.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хронический остеомиелит</kwd><kwd>кость и костные ткани</kwd><kwd>воспаление</kwd><kwd>посттравматический остеомиелит</kwd><kwd>послеоперационные осложнения</kwd><kwd>остеонекрэктомия</kwd><kwd>лазерная вапоризация</kwd><kwd>вакуумная терапия</kwd><kwd>ультразвуковая кавитация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic osteomyelitis</kwd><kwd>bone</kwd><kwd>inflammation</kwd><kwd>posttraumatic osteomyelitis</kwd><kwd>postoperative complications</kwd><kwd>osteonecrectomy</kwd><kwd>laser vaporisation</kwd><kwd>negative-pressure wound therapy</kwd><kwd>ultrasonic cavitation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Афанасьев А.В., Божкова С.А., Артюх В.А., Соломин Л.Н. Результат этапного лечения хронического рецидивирующего остеомиелита голени. Вестник хирургии им. И.И. Грекова. 2017;176(1):93–6.</mixed-citation><mixed-citation xml:lang="en">Afanas’ev A.V., Bozhkova S.A., Artyukh V.A., Solomin L.N. A staged treatment outcome of chronic recurrent lower leg osteomyelitis. Grekov’s Bulletin of Surgery. 2017;176(1):93–6 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Крючков Р.А., Хунафин С.Н., Кунафин М.С., Загретдинов А.Ш., Холкин С.А. К вопросу о ранней диагностике остеомиелита после остеосинтеза трубчатых костей с применением металлоконструкций. Медицинский вестник Башкортостана. 2014;9(1):89–92.</mixed-citation><mixed-citation xml:lang="en">Kryuchkov R.A., Khunafin S.N., Kunafin M.S., Zagretdinov A.Sh., Kholkin S.A. Osteomyelitis after osteosynthesis using metal structure in patients with closed fractures of tubular bones. Bashkortostan Medical Journal. 2014;9(1):89–92 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Рушай А.К. Значимость факторов в выборе лечебной тактики у больных с остеомиелитом конечностей. Травма. 2016;17(3):155– 58. DOI: 10.22141/1608-1706.3.17.2016.75801</mixed-citation><mixed-citation xml:lang="en">Rushay A.K. The factors importance for choice of disease management for patients with osteomyelitis of extremities. Trauma. 2016;17(3):155– 58 (In Russ.). DOI: 10.22141/1608-1706.3.17.2016.75801</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Сахаутдинов В.Г. Диагностика и комплексное лечение остеомиелита [автореф. диссертации]. Уфа;1975. 28 с.</mixed-citation><mixed-citation xml:lang="en">Sakhautdinov V.G. Diagnosis and combination treatment of osteomyelitis [extended abstract of dissertation]. Ufa; 1975.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Malat T.A., Glombitza M., Dahmen J., Hax P.M., Steinhausen E. The use of bioactive glass S53P4 as bone graft substitute in the treatment of chronic osteomyelitis and infected non-unions — a retrospective study of 50 patients. Z Orthop Unfall. 2018;156(2):152–9. DOI: 10.1055/s0043-124377</mixed-citation><mixed-citation xml:lang="en">Malat T.A., Glombitza M., Dahmen J., Hax P.M., Steinhausen E. The use of bioactive glass S53P4 as bone graft substitute in the treatment of chronic osteomyelitis and infected non-unions — a retrospective study of 50 patients. Z Orthop Unfall. 2018;156(2):152–9. DOI: 10.1055/s-0043-124377</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gokalp M.A., Guner S., Ceylan M.F., Doğan A., Sebik A. Results of treatment of chronic osteomyelitis by “gutter procedure and muscle flap transposition operation”. Eur J Orthop Surg Traumatol. 2014;24(3):415–19. DOI: 10.1007/s00590-013-1196-z</mixed-citation><mixed-citation xml:lang="en">Gokalp M.A., Guner S., Ceylan M.F., Doğan A., Sebik A. Results of treatment of chronic osteomyelitis by “gutter procedure and muscle flap transposition operation”. Eur J Orthop Surg Traumatol. 2014;24(3):415–19. DOI: 10.1007/s00590-013-1196-z</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Inzana J.A., Schwarz E.M., Kates S.L., Awad H.A. Biomaterials approaches to treating implant-associated osteomyelitis. Biomaterials. 2016;81:58–71. DOI: 10.1016/j.biomaterials.2015.12.012</mixed-citation><mixed-citation xml:lang="en">Inzana J.A., Schwarz E.M., Kates S.L., Awad H.A. Biomaterials approaches to treating implant-associated osteomyelitis. Biomaterials. 2016;81:58–71. DOI: 10.1016/j.biomaterials.2015.12.012</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lima A.L., Oliveira P.R., Carvalho V.C., Cimerman S., Savio E. Recommendations for the treatment of osteomyelitis. Braz J Infect Dis. 2014;18(5):526–34. DOI: 10.1016/j.bjid.2013.12.005</mixed-citation><mixed-citation xml:lang="en">Lima A.L., Oliveira P.R., Carvalho V.C., Cimerman S., Savio E. Recommendations for the treatment of osteomyelitis. Braz J Infect Dis. 2014;18(5):526–34. DOI: 10.1016/j.bjid.2013.12.005</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Panteli M., Giannoudis P.V. Chronic osteomyelitis: what the surgeon needs to know. EFORT Open Rev. 2017;1(5):128–35. DOI: 10.1302/2058-5241.1.000017</mixed-citation><mixed-citation xml:lang="en">Panteli M., Giannoudis P.V. Chronic osteomyelitis: what the surgeon needs to know. EFORT Open Rev. 2017;1(5):128–35. DOI: 10.1302/2058-5241.1.000017</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Амирасланов Ю.А., Митиш В.А., Борисов И.В., Жуков А.О. Современная классификация остеомиелита. Acta Biomedica Scientifica. 2011;(S4):18–9.</mixed-citation><mixed-citation xml:lang="en">Amiraslanov Yu.A., Mitish V.A., Borisov I.V., Zhukov A.O. Presentday classification of osteomyelitis. Acta Biomedica Scientifica. 2011;(S4):18–9 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hotchen A.J., McNally M.A., Sendi P. The classification of long bone osteomyelitis: a systemic review of the literature. J Bone Jt Infect. 2017;2(4):167–74. DOI: 10.7150/jbji.21050</mixed-citation><mixed-citation xml:lang="en">Hotchen A.J., McNally M.A., Sendi P. The classification of long bone osteomyelitis: a systemic review of the literature. J Bone Jt Infect. 2017;2(4):167–74. DOI: 10.7150/jbji.21050</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mandell J.C., Khurana B., Smith J.T., Czuczman G.J., Ghazikhanian V., Smith S.E. Osteomyelitis of the lower extremity: pathophysiology, imaging, and classification, with an emphasis on diabetic foot infection. Emerg Radiol. 2018;25(2):175–88. DOI: 10.1007/s10140-017-1564-9</mixed-citation><mixed-citation xml:lang="en">Mandell J.C., Khurana B., Smith J.T., Czuczman G.J., Ghazikhanian V., Smith S.E. Osteomyelitis of the lower extremity: pathophysiology, imaging, and classification, with an emphasis on diabetic foot infection. Emerg Radiol. 2018;25(2):175–88. DOI: 10.1007/s10140-017-1564-9</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C.Y., Hsieh R.W., Yen H.T., Hsu T.C., Chen C.Y., Chen Y.C., et al. Short-versus long-course antibiotics in osteomyelitis: A systematic review and meta-analysis. Int J Antimicrob Agents. 2019;53(3):246–60. DOI: 10.1016/j.ijantimicag.2019.01.007</mixed-citation><mixed-citation xml:lang="en">Huang C.Y., Hsieh R.W., Yen H.T., Hsu T.C., Chen C.Y., Chen Y.C., et al. Short-versus long-course antibiotics in osteomyelitis: A systematic review and meta-analysis. Int J Antimicrob Agents. 2019;53(3):246–60. DOI: 10.1016/j.ijantimicag.2019.01.007</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shemesh S., Kosashvili Y., Groshar D., Bernstine H., Sidon E., Cohen N., et al. The value of 18-FDG PET/CT in the diagnosis and management of implant-related infections of the tibia: a case series. Injury.2015;46(7):1377–82. DOI: 10.1016/j.injury.2015.03.002</mixed-citation><mixed-citation xml:lang="en">Shemesh S., Kosashvili Y., Groshar D., Bernstine H., Sidon E., Cohen N., et al. The value of 18-FDG PET/CT in the diagnosis and management of implant-related infections of the tibia: a case series. Injury.2015;46(7):1377–82. DOI: 10.1016/j.injury.2015.03.002</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fiorenza F., Durox H., El Balkhi S., Denes E. Antibiotic-loaded porous alumina ceramic for one-stage surgery for chronic osteomyelitis. J Am Acad Orthop Surg Glob Res Rev. 2018;2(11):e079. DOI: 10.5435/ JAAOSGlobal-D-18-00079</mixed-citation><mixed-citation xml:lang="en">Fiorenza F., Durox H., El Balkhi S., Denes E. Antibiotic-loaded porous alumina ceramic for one-stage surgery for chronic osteomyelitis. J Am Acad Orthop Surg Glob Res Rev. 2018;2(11):e079. DOI: 10.5435/ JAAOSGlobal-D-18-00079</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Panteli M., Puttaswamaiah R., Lowenberg D.W., Giannoudis P.V. Malignant transformation in chronic osteomyelitis: recognition and principles of management. J Am Acad Orthop Surg 2014;22:586–94. DOI: 10.5435/JAAOS-22-09-586</mixed-citation><mixed-citation xml:lang="en">Panteli M., Puttaswamaiah R., Lowenberg D.W., Giannoudis P.V. Malignant transformation in chronic osteomyelitis: recognition and principles of management. J Am Acad Orthop Surg 2014;22:586–94. DOI: 10.5435/JAAOS-22-09-586</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Maffulli N., Papalia R., Zampogna B., Torre G., Albo E., Denaro V. The management of osteomyelitis in the adult. Surgeon. 2016;14(6):345–60. DOI: 10.1016/j.surge.2015.12.005</mixed-citation><mixed-citation xml:lang="en">Maffulli N., Papalia R., Zampogna B., Torre G., Albo E., Denaro V. The management of osteomyelitis in the adult. Surgeon. 2016;14(6):345–60. DOI: 10.1016/j.surge.2015.12.005</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Marais L.C., Ferreira N. Bone transport through an induced membrane in the management of tibial bone defects resulting from chronic osteomyelitis. Strategies Trauma Limb Reconstr. 2015;10(1):27–33. DOI: 10.1007/s11751-015-0221-7</mixed-citation><mixed-citation xml:lang="en">Marais L.C., Ferreira N. Bone transport through an induced membrane in the management of tibial bone defects resulting from chronic osteomyelitis. Strategies Trauma Limb Reconstr. 2015;10(1):27–33. DOI: 10.1007/s11751-015-0221-7</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Lowenberg D.W., DeBaun M., Suh G.A Newer perspectives in the treatment of chronic osteomyelitis: A preliminary outcome report. Injury. 2019;50(Suppl. 1):S56–61. DOI: 10.1016/j.injury.2019.04.016</mixed-citation><mixed-citation xml:lang="en">Lowenberg D.W., DeBaun M., Suh G.A Newer perspectives in the treatment of chronic osteomyelitis: A preliminary outcome report. Injury. 2019;50(Suppl. 1):S56–61. DOI: 10.1016/j.injury.2019.04.016</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
