surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2019-9-4-293-296surgonco-438Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSТретичные лимфоидные структуры и прогноз при раке (краткий обзор)Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)https://orcid.org/0000-0003-2047-963XРустамхановР. А.RustamkhanovR. A.

Рустамханов Расул Айдарович — ассистент кафедры онкологии с курсами онкологии и патологической анатомии ИДПО

450008, Уфа, ул. Ленина, 3

Rustamkhanov Rasul Aydarovich — Assistant lecturer of the Department of Oncology with Oncology and Anatomical Pathology courses in the Institute of Additional Professional Education

3 Lenin str., Ufa, 450008

weather86@mail.ruhttps://orcid.org/0000-0002-7562-5684ГанцевК. Ш.GantsevK. Sh.

Ганцев Камиль Шамильевич — д.м.н., профессор кафедры онкологии, врачонколог урологического отделения № 7

450008, Уфа, ул. Ленина, 3;450054, Уфа, пр-т Октября, 73/1

Gantsev Kamil Shamilevich — Doctor of Medical Sciences, Professor of the Department of Oncology, Oncologist at the Department of Urology No. 7

3 Lenin str., Ufa, 450008;73/1 Oktyabrya ave., Ufa, 450054

gantseff@mail.ruhttps://orcid.org/0000-0003-4069-6594ТурсуметовД. С.TursumetovD. S.

Турсуметов Давлат Сайтмуратович — к.м.н., доцент кафедры онкологии с курсами онкологии и патологической анатомии ИДПО

450008, Уфа, ул. Ленина, 3

Tursumetov Davlat Saytmuratovich — Candidate of Medical Sciences, Associate Professor of the Department of Oncology with Oncology and Anatomical Pathology courses in the Institute of Additional Professional Education

ufa.davlat@gmail.comБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationБашкирский государственный медицинский университет; Республиканский клинический онкологический диспансерРоссияBashkir State Medical University; Republican Clinical Oncology CenterRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical University, 3 Lenin str., Ufa, 450008Russian Federation20192401202094293296Copyright © Рустамханов Р.А., Ганцев К.Ш., Турсуметов Д.С., 20202020Рустамханов Р.А., Ганцев К.Ш., Турсуметов Д.С.Rustamkhanov R.A., Gantsev K.S., Tursumetov D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/438

Данный краткий обзор посвящен роли третичных лимфоидных структур в онкологическом процессе. Проведенные за последние десять лет исследования проливают свет на функции таких структур при различных заболеваниях и их роль в прогрессировании патологического процесса или разрешении заболевания. Данные некоторых ученых подтверждают взаимосвязь между присутствием опухолеспецифических (опухолеассоциированных) третичных лимфоидных структур и благоприятным прогнозом у пациентов с различными онкологическими заболеваниями, что позволяет предположить участие третичных лимфоидных структур в эффективных локальных противоопухолевых иммунных реакциях. Однако определяющих доказательств в пользу содействия третичных лимфоидных структур иммунным процессам in vivo на данный момент нет, а имеющиеся в настоящее время сведения носят главным образом коррелятивный характер. Следует особо подчеркнуть, что клиническая значимость третичных лимфоидных структур колеблется от разрушительной до защитной, что свидетельствует о необходимости более четкого понимания структуры и функции этих структур, отличающихся в зависимости от конкретной ситуации, до проведения клинического таргетинга.

This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their role in the progression of the pathological process or resolution of a disease. The data presented in some research works confirms the relationship between the presence of tumour-specific (tumour-associated) tertiary lymphoid structures and a favourable prognosis in patients with various oncological diseases, which suggests the participation of tertiary lymphoid structures in effective local antitumour immune responses. However, no reliable evidence has so far been obtained that could confirm the contribution of tertiary lymphoid structures to immune processes in vivo, with the available information being largely of a correlative character. It should be emphasized that the clinical significance of tertiary lymphoid structures ranges from a destructive to protective impact, which indicates the need for an improved understanding of the structure and case-specific function of these organs before conducting clinical targeting.

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The authors declare that there are no conflicts of interest present.