surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2020-10-2-130-136surgonco-490Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSРанозаживляющие технологии: пути развития (обзор литературы)Outlook for Wound Healing Technologies (a Review)https://orcid.org/0000-0002-7026-9166ЧеботаревВ. В.ChebotarevV. V.

Чеботарев Вячеслав Владимирович — д.м.н., профессор, кафедра дерматовенерологии и косметологии с курсом ДПО.

тел.: +79624475355

Vyacheslav V. Chebotarev — Dr. Sci. (Med.), Professor, Department of Dermatovenereology and Cosmetology with a course of Advanced Professional Education.

тел.: +79624475355

sgmukvd@mail.ruhttps://orcid.org/0000-0001-8674-2803ХисматуллинаЗ. Р.KhismatullinaZ. R.

Хисматуллина Зарема Римовна — д.м.н ., профессор, кафедра дерматовенеролгии с курсами дерматовенерологии и косметологии ИДПО.

тел.: 89872554301

Zarema R. Khismatullina — Dr. Sci. (Med.), Professor, Department of Dermatovenereology with Advanced Professional Education Courses in Dermatovenereology and Cosmetology.

tel.: 8 987 2554301

hzr07@mail.ruhttps://orcid.org/0000-0003-3442-9684НасыроваЛ. К.NasyrovaL. K.

Насырова Лиана Камилевна — врач-терапевт.

тел.: 8-9677458360

Liana K. Nasyrova — Internist.

tel.: 89677458360

ufaliana2025@yandex.ruСтавропольский государственный медицинский университетРоссияStavropol State Medical UniversityRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationБашкирский государственный медицинский университет; Городская клиническая больница № 13РоссияBashkir State Medical University; City Clinical Hospital No. 13Russian Federation202025072020102130136Copyright © Чеботарев В.В., Хисматуллина З.Р., Насырова Л.К., 20202020Чеботарев В.В., Хисматуллина З.Р., Насырова Л.К.Chebotarev V.V., Khismatullina Z.R., Nasyrova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/490

Тканевая инженерия является одной из областей медицинской науки, главная задача которой состоит в воспроизведении биологических эквивалентов тканей и органов. Эта область медицины открывает возможности создания органов и тканей с помощью биоматериалов и наноструктур с целью их развития, поддержания и восстановления функционирования в живом организме. Главная цель тканевой инженерии — искусственно воссоздать наиболее точную структуру ткани. Для достижения данной цели необходимо наличие источника (донора) клеток, искусственного внеклеточного матрикса и ростового фактора. Первым органом, который удалось создать экстракорпорально, а также успешно применить в медицинских практиках, является кожа. В последние годы в технологии 3D-производства биологических структур произошел большой скачок. Большое внимание исследователи начали уделять технологии, которая позволяет создать регулируемое проектирование и производство 2D–3D-структур, состоящих из биологических материалов и жизнеспособных клеток. Такой процесс называется биопроизводством или биопрототипированием. Кожные заменители, полученные в результате применения технологии биопрототипирования, могут быть задействованы в широком спектре медицинских практик, но в первую очередь для замещения дефицита кожных покровов раневой поверхности.

Tissue engineering is a medical science dealing with reproduction of biological tissues and organs. This area of medicine opens avenues for creation of organs and tissues using biomaterials and nanostructures to sustain their development, maintenance and function repair in a living organism. The scope of tissue engineering is an artificial recreation of tissues at the fi nest structural level. Prerequisite requirements are a cell source (a donor), artificial extracellular matrix and growth factor. The first organ, which was extracorporally created and successfully introduced in medical practice, is skin. Recent years have witnessed a major leap in 3D technology for reproduction of biological structures. Increasing attention is being paid towards controlled design and production of 2D–3D structures consisting of biological materials and viable cells, the procedure defined as bioproduction or bioprototyping. Skin substitutes obtained with the bioprototyping technology possess a wide range of medical applications, primarily to compensate for resident skin deficiency in wound healing.

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The authors declare that there are no conflicts of interest present.