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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2020-10-4-302-310</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-534</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Вероятные механизмы патогенеза COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Probable Mechanisms of COVID-19 Pathogenesis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4091-382X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мустафин</surname><given-names>Р. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mustafin</surname><given-names>R. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.б.н., кафедра медицинской генетики и фундаментальной медицины</p><p>Уфа </p></bio><bio xml:lang="en"/><email xlink:type="simple">ruji79@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2987-3334</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хуснутдинова</surname><given-names>Э. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Khusnutdinova</surname><given-names>E. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.б.н., профессор</p><p>Уфа </p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт биохимии и генетики Уфимского федерального исследовательского центра РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biochemistry &amp; Genetics of Ufa Science Centre of the RAS</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2020</year></pub-date><volume>10</volume><issue>4</issue><fpage>302</fpage><lpage>310</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мустафин Р.Н., Хуснутдинова Э.К., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Мустафин Р.Н., Хуснутдинова Э.К.</copyright-holder><copyright-holder xml:lang="en">Mustafin R.N., Khusnutdinova E.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/534">https://www.surgonco.ru/jour/article/view/534</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>встройка</kwd><kwd>коронавирус</kwd><kwd>обратная транскриптаза</kwd><kwd>ретроэлементы</kwd><kwd>SARS­CoV­2</kwd><kwd>COVID­19</kwd><kwd>регуляция генной экспрессии</kwd><kwd>генетическая рекомбинация</kwd><kwd>РНК вирусы</kwd><kwd>микро­РНК</kwd><kwd>таргетная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>integration</kwd><kwd>coronavirus</kwd><kwd>reverse transcriptase</kwd><kwd>retrocells</kwd><kwd>SARS­CoV­2</kwd><kwd>COVID­19</kwd><kwd>gene expression regulation</kwd><kwd>genetic recombination</kwd><kwd>RNA viruses</kwd><kwd>microRNAs</kwd><kwd>targeted therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Tyrrell D.A., Bynoe M.L. 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