surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2021-11-1-92-99surgonco-576Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSСтромально-васкулярная фракция: биология и потенциальное применениеStromal Vascular Fraction: Biology and Application Outlookhttps://orcid.org/0000-0003-2125-4897ПавловВ. Н.PavlovV. N.

Павлов Валентин Николаевич — д.м.н., профессор, член-корр. РАН, кафедра урологии с курсом ИДПО 

Республика Башкортостан, Уфа

Valentin N. Pavlov — Dr. Sci. (Med.), Prof., RAS Corresponding Member, Department of Urology with a course of Advanced Professional Education

Ufa

КазихинуровА. А.KazikhinurovA. A.

Казихинуров Альберт Альфритович — д.м.н., профессор, кафедра урологии с курсом ИДПО 

Республика Башкортостан, Уфа

Albert A. Kazikhinurov — Dr. Sci. (Med.), Prof., Department of Urology with a course of Advanced Professional Education 

Ufa

КазихинуровР. А.KazikhinurovR. A.

Казихинуров Рустем Альфритович — к.м.н., доцент, кафедра урологии с курсом ИДПО 

Республика Башкортостан, Уфа

Rustem A. Kazikhinurov — Cand. Sci. (Med.), Assoc. Prof., Department of Urology with a course of Advanced Professional Education 

Ufa

АгавердиевМ. А.AgaverdievM. A.

Агавердиев Мурад Арифович — кафедра урологии с курсом ИДПО 

Республика Башкортостан, Уфа

Murad A. Agaverdiev — Department of Urology with a course of Advanced Professional Education

Ufa

https://orcid.org/0000-0002-4965-0835ГареевИ. Ф.GareevI. F.

Гареев Ильгиз Фанилевич — к.м.н., Центральная научно-исследовательская лаборатория (ЦНИЛ) 

Республика Башкортостан, Уфа

Ilgiz F. Gareev — Cand. Sci. (Med.), Central Research Laboratory 

Ufa

ilgiz_gareev@mail.ruhttps://orcid.org/0000-0002-6149-5460БейлерлиО. А.BeylerliO. A.

Бейлерли Озал Арзуман оглы — Центральная научно-исследовательская лаборатория (ЦНИЛ) 

Республика Башкортостан, Уфа

Ozal A. Beylerli — Central Research Laboratory 

Ufa

МазоровБ. З.MazorovB. Z.

Мазоров Баходур Зурибекович — кафедра урологии с курсом ИДПО

Республика Башкортостан, Уфа

Bakhodur Z. Mazorov — Department of Urology with a Course of Advanced Professional Education 

Ufa

Башкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian Federation2021200420211119299Copyright © Павлов В.Н., Казихинуров А.А., Казихинуров Р.А., Агавердиев М.А., Гареев И.Ф., Бейлерли О.А., Мазоров Б.З., 20212021Павлов В.Н., Казихинуров А.А., Казихинуров Р.А., Агавердиев М.А., Гареев И.Ф., Бейлерли О.А., Мазоров Б.З.Pavlov V.N., Kazikhinurov A.A., Kazikhinurov R.A., Agaverdiev M.A., Gareev I.F., Beylerli O.A., Mazorov B.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/576

Стромально-васкулярную фракцию (СВФ) можно определить как гетерогенную популяцию свежевыделенных клеток из жировой ткани после ферментативной диссоциации с последующим центрифугированием. Эта популяция клеток включает множество различных типов клеток, таких как стволовые клетки жировой ткани (СКЖТ), эндотелиальные и гладкомышечные клетки кровеносных сосудов и их предшественники, перициты, фибробласты, макрофаги, Т-лимфоциты и т. д., но не включает зрелые адипоциты. Основным компонентом СВФ являются СКЖТ, которые способны к самообновлению и мультипотентной дифференцировке. Со времен открытия и изучения СВФ были проведены многочисленные исследования возможностей ее клинического применения, показавшие значительные успехи в использовании СВФ при лечении различных заболеваний и травм. За последние 10 лет наблюдается тенденция к увеличению количества публикаций, в которых показаны фундаментальные и клинические исследования о терапевтическом использовании СВФ. За это время было разработано множество различных методов и устройств для выделения СВФ из липоаспирата человека, полученного посредством липосакции, и постоянно растет число отчетов о результатах доклинических и клинических исследований в пользу безопасности и эффективности СВФ. В данной обзорной статье мы обсудим основные свойства и функции клеточной популяции СВФ, а также эффективность и безопасность ее применения в терапии заболеваний человека.

Stromal vascular fraction (SVF) is a heterogeneous cell extract obtained with enzymatic dissociation of adipose tissue followed by centrifugation. This population includes many different cell types, i.a. adipose tissue stem cells (ATSCs), vascular endothelial and smooth muscle cells and their precursors, pericytes, fibroblasts, macrophages, T-lymphocytes, etc., excluding mature adipocytes. The main SVF component is ATSCs capable of self-renewal and multipotent differentiation. Since early research on SVF, an extensive effort has been aimed at understanding its clinical applications promoting a significant progress in the SVF use for treatment of various diseases and injuries. The past decade has witnessed an upward publication trend in basic and clinical research into the SVF therapeutic value. Manifold methods and devices for the SVF isolation from human liposuction lipoaspirate have been developed, continuously contributing to preclinical and clinical trials of its safety and efficacy. This review discusses the main properties and functions of the SVF cell population, its efficacy and safety for human therapy.

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The authors declare that there are no conflicts of interest present.