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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2021-11-3-256-259</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-608</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF COMMUNICATIONS</subject></subj-group></article-categories><title-group><article-title>Физико-химические свойства антисептических средств: что мы не учитываем в лечении длительно незаживающих ран</article-title><trans-title-group xml:lang="en"><trans-title>Physico-Chemical Properties of Antiseptics in Surgery: What is not Taken into Account in Treating Long-Term Non-Healing Wounds</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Bodduluri</surname><given-names>V. P.</given-names></name><name name-style="western" xml:lang="en"><surname>Bodduluri</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Bodduluri Vishwanath Pradeep – кафедра фармацевтических наук</p><p>Хайдарабад</p></bio><bio xml:lang="en"><p>Vishwanath Pradeep – Bodduluri Department of Pharmaceutical Sciences</p><p>Hyderabad</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7603-6064</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуревич</surname><given-names>К. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurevich</surname><given-names>K. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гуревич Константин Георгиевич – д.м.н., профессор, кафедра здорового образа жизни</p></bio><bio xml:lang="en"><p>Konstantin G. Gurevich – Dr. Sci. (Med.), Prof., Department of Healthy Lifestyle</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9829-9463</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ураков</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Urakov</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ураков Александр Ливиевич – д.м.н., профессор, кафедра общей и клинической фармакологии</p><p>Удмуртская Республика, Ижевск</p></bio><bio xml:lang="en"><p>Alexander L. Urakov – Dr. Sci. (Med.), Prof., Department of General and Clinical Pharmacology</p><p>Izhevsk</p></bio><email xlink:type="simple">urakoval@live.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Фармацевтический институт Крави</institution><country>Индия</country></aff><aff xml:lang="en"><institution>Kravi Pharmaceutical Institute</institution><country>India</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет имени А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Ижевская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Izhevsk State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>01</day><month>10</month><year>2021</year></pub-date><volume>11</volume><issue>3</issue><fpage>256</fpage><lpage>259</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bodduluri V.P., Гуревич К.Г., Ураков А.Л., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Bodduluri V.P., Гуревич К.Г., Ураков А.Л.</copyright-holder><copyright-holder xml:lang="en">Bodduluri V.P., Gurevich K.G., Urakov A.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/608">https://www.surgonco.ru/jour/article/view/608</self-uri><abstract><p>При лечении длительно незаживающих ран в условиях отделений гнойной хирургии широко используются растворы химиотерапевтических и антисептических средств. До сих пор распространено применение растворов 3–6 % перекиси водорода и 2–10 % натрия хлорида. Как правило, растворы этих лекарственных средств используют для лечения незаживающих, в частности гнойных, ран, пролежней и трофических язв. Поэтому растворы вводят в область ран многократно в виде курсовой терапии. Показано, что механизм действия указанных лекарственных средств и эффект лечения длительно незаживающих ран во многом определяется такими физико-химическими факторами их локального взаимодействия, как концентрация основных ингредиентов, осмотическая, щелочная активность и локальная температура. Указывается ведущая роль локальной температуры и зависимость локального эффекта от концентрации. Описывается сущность инновационного способа лечения.</p></abstract><trans-abstract xml:lang="en"><p>The treatment of long-term non-healing wounds in the conditions of purulent surgery departments, widely uses solutions of chemotherapeutic and antiseptic agents. The most common are the solutions of 3–6 % hydrogen peroxide and solutions of 2–10 % sodium chloride. As a rule, solutions of these drugs are used to treat non-healing, particularly, purulent wounds, bedsores and trophic ulcers. Therefore, solutions are injected into the wound area repeatedly in the form of course therapy. The findings show that the mechanism of action of these drugs and the effect of treating long-term non-healing wounds is largely determined by such physical and chemical factors of their local interaction as concentration of the main ingredients, osmotic, alkaline activity and local temperature. The findings point out the leading role of the local temperature and the dependence of the local effect on the concentration. They describe the essence of the innovative method of treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гнойная хирургия</kwd><kwd>трофические язвы</kwd><kwd>антисептические средства</kwd><kwd>санирование гнойных ран</kwd><kwd>температура</kwd><kwd>перекись водорода</kwd><kwd>натрий хлорид</kwd></kwd-group><kwd-group xml:lang="en"><kwd>purulent surgery</kwd><kwd>trophic ulcers</kwd><kwd>antiseptics</kwd><kwd>sanitization of purulent wounds</kwd><kwd>temperature</kwd><kwd>hydrogen peroxide</kwd><kwd>sodium chloride</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Tretyakov A.A., Petrov S.V., Neverov A.N., Shchtinin A.F. Treatment of purulent wounds. Novosti Khirurgii. 2015; 23(6):680–7 (In Russ.) DOI: 10.18484/2305-0047.2015.6.680</mixed-citation><mixed-citation xml:lang="en">Tretyakov A.A., Petrov S.V., Neverov A.N., Shchtinin A.F. 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