surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2022-12-4-309-319surgonco-738Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSВозможности применения комбинации ленватиниба и пембролизумаба при распространенной эндометриальной карциномеPossible applications for combined lenvatinib and pembrolizumab in advanced endometrial carcinomahttps://orcid.org/0000-0003-3734-2779МеньшиковК. В.MenshikovK. V.

Меньшиков Константин Викторович — к.м.н., доцент, кафедра онкологии с курсами онкологии и патологической анатомии ИДПО, отдел химиотерапии

Республика Башкортостан, Уфа

Кonstantin V. Menshikov — Cand. Sci. (Med.), Assoc. Prof., Department of Oncology with Courses of Oncology and Pathological Anatomy for Advanced Professional Education, Chemotherapy Unit,

Ufa, Russian Federation

kmenshikov80@bk.ruhttps://orcid.org/0000-0003-0996-5995СултанбаевА. В.SultanbaevA. V.

Султанбаев Александр Валерьевич — к.м.н., отдел противоопухолевой лекарственной терапии

Республика Башкортостан, Уфа

Alexander V. Sultanbaev — Cand. Sci. (Med.), Antiсancer Drug Therapy Unit

Ufa, Russian Federation

https://orcid.org/0000-0003-1185-977XМусинШ. И.MusinSh. I.

Мусин Шамиль Исмагилович — к.м.н., хирургическое отделение № 6

Республика Башкортостан, Уфа

Shamil I. Musin — Cand. Sci. (Med.), Surgery Unit No. 6

Ufa, Russian Federation

https://orcid.org/0000-0002-8665-8895МеньшиковаИ. А.MenshikovaI. A.

Меньшикова Ирина Асхатовна — к.м.н., доцент, кафедра биологической химии

Республика Башкортостан, Уфа

Irina A. Menshikova — Cand. Sci. (Med.), Assoc. Prof., Department of Biological Chemistry

Ufa, Russian Federation

https://orcid.org/0000-0001-5926-0446СултанбаеваН. И.SultanbaevaN. I.

Султанбаева Надежда Ивановна — отделение противоопухолевой лекарственной терапии № 1

Республика Башкортостан, Уфа

Nadezhda I. Sultanbaeva — Antiсancer Drug Therapy Unit No. 1

Ufa, Russian Federation

https://orcid.org/0000-0002-8461-9243ИзмайловА. А.IzmailovA. A.

Измайлов Адель Альбертович — д.м.н., доцент, кафедра урологии с курсом ИДПО

Республика Башкортостан, Уфа

Adel A. Izmailov — Dr. Sci. (Med.), Assoc. Prof., Department of Urology with a Course of Advanced Professional Education

Ufa, Russian Federation

https://orcid.org/0000-0001-7821-0188ФатиховаА. А.FatikhovaA. A.

Фатихова Альфия Азатовна — хирургическое отделение № 8

Республика Башкортостан, Уфа

Alfi ya A. Fatikhova — Surgery Unit No. 8

Ufa, Russian Federation

https://orcid.org/0000-0002-3193-9008ЛипатовД. О.LipatovD. O.

Липатов Данила Олегович

Республика Башкортостан, Уфа

Danila O. Lipatov

Ufa, Russian Federation

https://orcid.org/0000-0002-7082-0085СеребренниковГ. А.SerebrennikovG. A.

Серебренников Григорий Андреевич — отделение противоопухолевой лекарственной терапии № 2

Республика Башкортостан, Уфа

Grigoriy A. Serebrennikov — Antiсancer Drug Therapy Unit No. 2

Ufa, Russian Federation

Республиканский клинический онкологический диспансер; Башкирский государственный медицинский университетРоссияRepublican Clinical Oncology Dispensary; Bashkir State Medical UniversityRussian FederationРеспубликанский клинический онкологический диспансерРоссияRepublican Clinical Oncology DispensaryRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationБашкирский государственный медицинский университетРоссияRepublican Clinical Oncology DispensaryRussian FederationРеспубликанский клинический онкологический диспансерРоссияBashkir State Medical UniversityRussian Federation202205012023124309319Copyright © Меньшиков К.В., Султанбаев А.В., Мусин Ш.И., Меньшикова И.А., Султанбаева Н.И., Измайлов А.А., Фатихова А.А., Липатов Д.О., Серебренников Г.А., 20232023Меньшиков К.В., Султанбаев А.В., Мусин Ш.И., Меньшикова И.А., Султанбаева Н.И., Измайлов А.А., Фатихова А.А., Липатов Д.О., Серебренников Г.А.Menshikov K.V., Sultanbaev A.V., Musin S.I., Menshikova I.A., Sultanbaeva N.I., Izmailov A.A., Fatikhova A.A., Lipatov D.O., Serebrennikov G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/738

Рак эндометрия является одним из наиболее распространенных видов гинекологического рака как в Соединенных Штатах, так и в Российской Федерации, и этот показатель продолжает расти. Несмотря на то что ранние стадии рака эндометрия ассоциируются с благоприятной 5-летней выживаемостью (96 %), у пациенток с отдаленными метастазами этот показатель составляет всего лишь 18 %. Комбинация паклитаксела и карбоплатина является стандартным режимом первой линии для лечения прогрессирующей, рецидивирующей и метастатической карциномы эндометрия. Пембролизумаб, моноклональное антитело, нацеленное на рецептор запрограммированной смерти-1, одобрен для терапии метастатических солидных опухолей с высокой микросателлитной нестабильностью, которые прогрессировали после предшествующей терапии и не имели альтернативных вариантов лечения. Ленватиниб является пероральным мультикиназным ингибитором, который нацелен на рецепторы фактора роста эндотелия сосудов 1–3, рецепторы фактора роста фибробластов 1–4, рецептор фактора роста тромбоцитов-a, RET и KIT. Исследования II и III фазы (KEYNOTE-146/Study111 и KEYNOTE-775), посвященные комбинации ленватиниба и пембролизумаба при распространенной эндометриальной карциноме вне зависимости от статуса MMR и MSI, продемонстрировали новые возможности в лечении этой патологии. Полученные результаты, в том числе и выживаемость без прогрессирования и общая выживаемость, позволяют рассматривать комбинацию ленватиниба и пембролизумаба как новый стандарт в лечении данной патологии.

Endometrial cancer is one of the most common gynaecological cancers in both the United States and the Russian Federation, and the rate continues to rise. Although early-stage endometrial cancer is associated with a favourable 5-year survival rate (96%), this rate in patients with distant metastases accounts for only 18%. A combination of paclitaxel and carboplatin is standard first-line therapy for advanced, recurrent and metastatic endometrial carcinoma. Pembrolizumab, a monoclonal antibody targeting the programmed death-1 receptor, is approved for therapy of metastatic solid tumors with high microsatellite instability that have progressed aft er previous therapy and have no alternative treatment options. Lenvatinib is an oral multikinase inhibitor that blocks vascular endothelial growth factor receptors 1-3, fibroblast growth factor receptors 1-4, platelet-derived growth factor receptor alpha, RET and KIT. Phase II and III studies (KEYNOTE-146/ Study111 and KEYNOTE-775) on the combination of lenvatinib and pembrolizumab in advanced endometrial carcinoma, irrespective of MMR and MSI status, have shown new potential for the treatment of this pathology. Th e results obtained, including progression-free and overall survival, allow the combination of lenvatinib and pembrolizumab to be considered a new standard for the treatment of this pathology.

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The authors declare that there are no conflicts of interest present.