surgoncoКреативная хирургия и онкологияCreative surgery and oncology2076-30932307-0501Башкирский государственный медицинский университет10.24060/2076-3093-2023-13-1-68-76surgonco-773Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSБолезнь Боуэна (обзор литературы)Bowen's Disease: Literature Reviewhttps://orcid.org/0000-0001-8674-2803ХисматуллинаЗ. Р.KhismatullinaZ. R.

Хисматуллина Зарема Римовна — д.м.н., профессор, кафедра дерматовенерологии с курсами дерматовенерологии и косметологии ИДПО

Республика Башкортостан, Уфа

 

Zarema R. Khismatullina — Dr. Sci. (Med.), Prof., Department of Dermatovenerology with Courses of Dermatovenerology and Cosmetology for Advanced Professional Education

Ufa

https://orcid.org/0000-0001-6490-9529ЛиповаЕ. В.LipovaE. V.

Липова Елена Валерьевна — д.м.н., профессор, кафедра дерматовенерологии и косметологии с курсом клинической лабораторной диагностики

Москва

Elena V. Lipova — Dr. Sci. (Med.), Prof., Department of Dermatovenerology and Cosmetology with a Course of Clinical Laboratory Diagnostics

Moscow

https://orcid.org/0000-0003-4556-1867ХамматоваА. А.KhammatovaA. A.

Хамматова Алсу Анваровна — дерматологическое отделение № 1

Республика Башкортостан, Уфа

Alsu A. Khammatova — Dermatology Unit No. 1

Ufa

https://orcid.org/0000-0001-9650-3400ХабибуллинаМ. И.KhabibullinaM. I.

Хабибуллина Миляуша Ильмировна — кафедра дерматовенерологии с курсами дерматовенерологии и косметологии ИДПО

Республика Башкортостан, Уфа

Milyausha I. Khabibullina — Department of Dermatovenerology with Courses of Dermatovenerology and Cosmetology for Advanced Professional Education

Ufa

https://orcid.org/0000-0003-3457-5673НаджафизадеЭ.NajafizadeE.

Наджафизаде Элахе — кафедра дерматовенерологии с курсами дерматовенерологии и косметологии ИДПО

Республика Башкортостан, Уфа

Elakhe Najafizade — Department of Dermatovenerology with Courses of Dermatovenerology and Cosmetology for Advanced Professional Education

Ufa

https://orcid.org/0000-0001-7217-960XЯнбарисоваК. З.IanbarisovaK. Z.

Янбарисова Камилла Зинфировна — студентка 6-го курса

Республика Башкортостан, Уфа

Kamilla Z. Ianbarisova — 6th year Student

Ufa

Башкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationМедико-биологический университет инноваций и непрерывного образования ФМБЦ им. А.И. Бурназяна ФМБАРоссияA.I. Burnasyan Federal Medical Biophysical Center FMBARussian FederationРеспубликанский кожно-венерический диспансерРоссияRepublican Dermatovenereal DispensaryRussian Federation2023050420231316876Copyright © Хисматуллина З.Р., Липова Е.В., Хамматова А.А., Хабибуллина М.И., Наджафизаде Э., Янбарисова К.З., 20232023Хисматуллина З.Р., Липова Е.В., Хамматова А.А., Хабибуллина М.И., Наджафизаде Э., Янбарисова К.З.Khismatullina Z.R., Lipova E.V., Khammatova A.A., Khabibullina M.I., Najafizade E., Ianbarisova K.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgonco.ru/jour/article/view/773

В статье представлены результаты научных исследований по проблеме болезни Боуэна за последние 15 лет. Этиопатогенез заболевания до конца не изучен, однако большинство специалистов указывают на следующие триггерные факторы: длительный прием лекарственных средств, подавляющих иммунный ответ, вирус папилломы человека, светлый тип кожи и чрезмерное воздействие на нее солнечного света, ионизирующее излучение, прием мышьяка. Клинические варианты проявления болезни Боуэна представляют собой анулярную, веррукозную, пигментную и акральную формы. К нетипичным вариантам заболевания относится «гигантская» болезнь Боуэна и случаи локализации поражений на лице. В статье описана клиническая симптоматика каждой клинической формы болезни Боуэна, описаны диагностические методы и предложены различные методы лечения, используемые в зарубежной и отечественной практике. Приведены сравнительные результаты исследований по таким способам лечения болезни Боуэна, как оперативное удаление, микрографическая операция Мооса, фотодинамическая терапия, кюретаж, криотерапия, лазерная абляция, лучевая терапия, а также консервативные методы лечения. Последние включают в себя местное применение лекарственных наружных средств (фторурацил, имиквимод, диклофенак), так как в определенных случаях они могут быть достаточно эффективными. Отмечены преимущества метода фотодинамической терапии как по высокой эффективности, так и по спектру безопасности лечения болезни Боуэна.

The paper presents the results of the bibliographic research materials on Bowen's disease over the past 15 years. The aetiopathogenesis of the disease is not yet fully understood; however, most experts designate the following trigger factors: prolonged use of drugs that suppress the immune response, human papillomavirus, light skin type, and excessive exposure to sunlight, ionizing radiation, arsenic intake. Clinical manifestations of Bowen's disease take anular, verrucous, pigmented, and acral forms. Atypical variants of the disease include “giant” Bowen's disease, and cases of localization of lesions on the face. The paper describes the clinical symptoms of each clinical form of Bowen's disease, diagnostic methods, and various treatment methods used in foreign and domestic practice. Comparative results of research on the treatment methods of Bowen's disease include such methods as surgical removal, Mohs micrographic surgery, photodynamic therapy, curettage, cryotherapy, laser ablation, radiation therapy as well as conservative treatment methods. The latter include topical application of external remedies (fluorouracil, imiquimod, diclofenac), as they can be quite effective in certain cases. The advantages of photodynamic therapy are indicated both in terms of high efficiency and in the safety spectrum of treatment of Bowen's disease.

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The authors declare that there are no conflicts of interest present.