<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2023-13-3-203-209</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-828</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Предикторы неблагоприятных клинических исходов эндоваскулярной тромбэктомии в острейшем периоде ишемического инсульта</article-title><trans-title-group xml:lang="en"><trans-title>Predictors of Adverse Clinical Outcomes after Endovascular Thrombectomy in Acute Ischemic Stroke</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4822-9229</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вильданов</surname><given-names>Т. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Vildanov</surname><given-names>T. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вильданов Тагир Рафаэлевич — аспирант, кафедра госпитальной хирургии, отделение рентгенохирургических методов диагностики и лечения</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Tagir R. Vildanov - Postgraduate Student, Department of Hospital Surgery, X-Ray Surgical Methods of Diagnosis and Treatment Unit</p><p>Ufa</p></bio><email xlink:type="simple">vildanov.tag@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6716-4048</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плечев</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Plechev</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плечев Владимир Вячеславович - д.м.н., профессор, кафедра госпитальной хирургии</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Vladimir V. Plechev - Dr. Sci. (Med.), Prof., Department of Hospital Surgery</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5823-0804</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загидулина</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagidulina</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загидулина Мария Сергеевна - отделение рентгенохирургических методов диагностики и лечения</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Maria S. Zagidulina - X-Ray Surgical Methods of Diagnosis and Treatment Unit</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2802-6694</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чудновец</surname><given-names>Л. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Chudnovets</surname><given-names>L. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чудновец Лев Георгиевич - к.м.н., отделение рентгенохирургических методов диагностики и лечения</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Lev G. Chudnovets - Cand. Sci. (Med.), X-Ray Surgical Methods of Diagnosis and Treatment Unit</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9294-5778</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колчина</surname><given-names>Э. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolchina</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колчина Эмма Михайлов на - к.м.н., неврологическое отделение для больных с острыми нарушениями мозгового кровообращения</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Emma M. Kolchina - Cand. Sci. (Med.), Unit of Neurology for Patients with Acute Cerebrovascular Disorders</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8594-737X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карамова</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Karamova</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карамова Ирина Марсиловна - д.м.н., профессор</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Irina M. Karamova - Dr. Sci. (Med.), Prof.</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-6617-5417</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плечева</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Plecheva</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плечева Дина Владимировна - д.м.н., кафедра госпитальной хирургии</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Dina V. Plecheva - Dr. Sci. (Med.), Department of Hospital Surgery</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-0823-8369</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чудновец</surname><given-names>Г. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Chudnovets</surname><given-names>G. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чудновец Георгий Львович - студент 6-го курса</p><p>Республика Башкортостан, Уфа</p></bio><bio xml:lang="en"><p>Georgiy L. Chudnovets - 6th year Student</p><p>Ufa</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет; Городская клиническая больница № 21</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University; City Clinical Hospital No. 21</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Клиническая больница скорой медицинской помощи</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Emergency Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>04</day><month>10</month><year>2023</year></pub-date><volume>13</volume><issue>3</issue><fpage>203</fpage><lpage>209</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вильданов Т.Р., Плечев В.В., Загидулина М.С., Чудновец Л.Г., Колчина Э.М., Карамова И.М., Плечева Д.В., Чудновец Г.Л., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Вильданов Т.Р., Плечев В.В., Загидулина М.С., Чудновец Л.Г., Колчина Э.М., Карамова И.М., Плечева Д.В., Чудновец Г.Л.</copyright-holder><copyright-holder xml:lang="en">Vildanov T.R., Plechev V.V., Zagidulina M.S., Chudnovets L.G., Kolchina E.M., Karamova I.M., Plecheva D.V., Chudnovets G.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/828">https://www.surgonco.ru/jour/article/view/828</self-uri><abstract><p>Введение. В мире инсульт является одной из самых значимых социально-экономических проблем. В последнее десятилетие все чаще для восстановления нарушенного мозгового кровотока в первые часы с момента заболевания применяются эндоваскулярные вмешательства, в том числе механическая тромбэктомия из церебральных артерий. Однако было замечено, что технический успех операции не всегда сопровождался улучшением клинического состояния пациентов.Материалы и методы. В исследовании ретроспективно были проанализированы результаты вмешательств у 86 пациентов с острым ишемическим инсультом с целью выявления факторов, способных оказывать негативное влияние на течение заболевания в первые часы и потенциально ухудшающих результаты реперфузионной терапии. Пациенты были в возрасте от 35 до 85 лет (средний возраст — 66,82 ± 1,52 года), преобладали мужчины (57 против 29). У 42 пациентов (49 %) имелась фибрилляция предсердий, из них у 28 (66,7 %) — постоянная форма, у 11 (26,2 %) — пароксизмальная форма, у 3 — персистирующая форма (7,1 %). У 27 (31,4 %) — сахарный диабет.Результаты и обсуждение. По итогам исследования выявлены факторы, влияющие на исход и отдаленные годичные результаты. К ним отнесли тяжесть неврологического дефицита по шкале Рэнкин и NIHSS, время от начала симптоматики до реперфузии, результат тромбэктомии по шкале TICI, возраст, наличие сахарного диабета, геморрагическая трансформация после тромбэктомии.Заключение. Для достижения лучших результатов необходима разработка оптимальной схемы маршрутизации пациентов, при которой следует обращать особое внимание на исходную тяжесть неврологического дефицита, время от начала заболевания, возраст больных, сопутствующий сахарный диабет, развитие геморрагической трансформации после проведения эндоваскулярной тромбэктомии и особенно на сочетание неблагоприятных факторов.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Stroke is recognized as one of the most significant global socio-economic issues. Endovascular interventions, including mechanical thrombectomy of cerebral arteries, have been increasingly performed during the past decade to restore impaired cerebral blood flow in the first hours from the onset of the disease. However, it has been observed that the technical success of the procedure does not always imply an improvement in the clinical condition of a patient.Materials and methods. The study retrospectively analyzes the outcomes of interventions in 86 acute ischemic stroke patients in order to identify factors that can exert an adverse effect on the first hours of the disease and potentially worsen the results of reperfusion therapy. The study involves patients aged 35–85 years (mean age 66.82±1.52 years), predominantly males (57 males versus 29 females). 42 patients (49%) suffered atrial fibrillation, of which 28 (66.7%) had permanent, 11 (26.2%) — paroxysmal, 3 — persistent atrial fibrillation (7.1%), and 27 (31.4%) suffered diabetes mellitus.Results and discussion. Based on the study, factors affecting outcome and one-year long-term results were identified. The predictors included severity of neurological deficit according to Rankin and NIH Stroke scales, time between symptom onset and reperfusion, TICI thrombectomy score, age, diabetes mellitus, and haemorrhagic transformation after thrombectomy.Conclusion. In order to ensure better outcomes, medical specialists should develop an efficient patient routing, pay special attention to the initial severity of neurological deficit, time from the onset of the disease, age of patients, concomitant diabetes mellitus, development of hemorrhagic transformation after endovascular thrombectomy, and, which is particularly important, to the combination of adverse factors.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемический инсульт</kwd><kwd>внутрисосудистая тромбэктомия</kwd><kwd>факторы риска</kwd><kwd>реперфузия</kwd><kwd>церебральная окклюзия</kwd><kwd>неблагоприятный исход</kwd><kwd>гипергликемия</kwd><kwd>геморрагическая трансформация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ischemic stroke</kwd><kwd>intravascular thrombectomy</kwd><kwd>risk factors</kwd><kwd>reperfusion</kwd><kwd>cerebral occlusion</kwd><kwd>adverse outcome</kwd><kwd>hyperglycemia</kwd><kwd>hemorrhagic transformation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kuriakose D., Xiao Z. Pathophysiology and treatment of stroke: Present status and future perspectives. Int J Mol Sci. 2020;21(20):1–24. DOI: 10.3390/ijms21207609</mixed-citation><mixed-citation xml:lang="en">Kuriakose D., Xiao Z. Pathophysiology and treatment of stroke: Present status and future perspectives. Int J Mol Sci. 2020;21(20):1–24. DOI: 10.3390/ijms21207609</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Abdullahi W., Tripathi D., Ronaldson P.T. Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection. Am J Physiol Cell physiology. 2018;315(3):343–56. DOI: 10.1152/ajpcell.00095.2018</mixed-citation><mixed-citation xml:lang="en">Abdullahi W., Tripathi D., Ronaldson P.T. Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection. Am J Physiol Cell physiology. 2018;315(3):343–56. DOI: 10.1152/ajpcell.00095.2018</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Saver J.L., Goyal M., Bonafe A., Diener H.Ch., Levy E.I., Pereira V.M., et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Medicine. 2015;372(24):2285–95. DOI: 10.1056/NEJMoa1415061</mixed-citation><mixed-citation xml:lang="en">Saver J.L., Goyal M., Bonafe A., Diener H.Ch., Levy E.I., Pereira V.M., et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Medicine. 2015;372(24):2285–95. DOI: 10.1056/NEJMoa1415061</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Goyal M., Menon B.K., van Zwam W.H., Dippel D.W., Mitchell P.J., Demchuk A.M., et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387(10029):1723–31. DOI: 10.1016/ S0140-6736(16)00163-X</mixed-citation><mixed-citation xml:lang="en">Goyal M., Menon B.K., van Zwam W.H., Dippel D.W., Mitchell P.J., Demchuk A.M., et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387(10029):1723–31. DOI: 10.1016/ S0140-6736(16)00163-X</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bourcier R., Goyal M., Muir K.W., Desal H., Dippel D.W.J., Majoie C.B.L.M., et al. Risk factors of unexplained early neurological deterioration after treatment for ischemic stroke due to large vessel occlusion: a post hoc analysis of the HERMES study. J Neurointerv Surg. 2023;15(3):221–26. DOI: 10.1136/neurintsurg-2021-018214</mixed-citation><mixed-citation xml:lang="en">Bourcier R., Goyal M., Muir K.W., Desal H., Dippel D.W.J., Majoie C.B.L.M., et al. Risk factors of unexplained early neurological deterioration after treatment for ischemic stroke due to large vessel occlusion: a post hoc analysis of the HERMES study. J Neurointerv Surg. 2023;15(3):221–26. DOI: 10.1136/neurintsurg-2021-018214</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Prasetya H., Ramos L.A., Epema T., Treurniet K.M., Emmer B.J., Wijngaard I.R., et al. qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients. Int J Stroke. 2021;16(2):207–216. DOI: 10.1177/1747493020909632</mixed-citation><mixed-citation xml:lang="en">Prasetya H., Ramos L.A., Epema T., Treurniet K.M., Emmer B.J., Wijngaard I.R., et al. qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients. Int J Stroke. 2021;16(2):207–216. DOI: 10.1177/1747493020909632</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Liebeskind D.S., Bracard S., Guillemin F., Jahan R., Jovin T.G., Majoie C.B., et al. eTICI reperfusion: defining success in endovascular stroke therapy. J Neurointerv Surg. 2019;11(5):433–8. DOI: 10.1136/neurintsurg-2018-014127</mixed-citation><mixed-citation xml:lang="en">Liebeskind D.S., Bracard S., Guillemin F., Jahan R., Jovin T.G., Majoie C.B., et al. eTICI reperfusion: defining success in endovascular stroke therapy. J Neurointerv Surg. 2019;11(5):433–8. DOI: 10.1136/neurintsurg-2018-014127</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Arba F., Rinaldi C., Caimano D., Vit F., Busto G., Fainardi E. Bloodbrain barrier disruption and hemorrhagic transformation in acute ischemic stroke: systematic review and meta-analysis. front neurol. 2021;21(11):594613. DOI: 10.3389/fneur.2020.594613</mixed-citation><mixed-citation xml:lang="en">Arba F., Rinaldi C., Caimano D., Vit F., Busto G., Fainardi E. Bloodbrain barrier disruption and hemorrhagic transformation in acute ischemic stroke: systematic review and meta-analysis. front neurol. 2021;21(11):594613. DOI: 10.3389/fneur.2020.594613</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Morinaga Y., Nii K., Takemura Y., Hanada H., Sakamoto K., Hirata Y., et al. Types of intraparenchymal hematoma as a predictor after revascularization in patients with anterior circulation acute ischemic stroke. Surg Neurol Int. 2021;17(12):102. DOI: 10.25259/SNI_792_2020</mixed-citation><mixed-citation xml:lang="en">Morinaga Y., Nii K., Takemura Y., Hanada H., Sakamoto K., Hirata Y., et al. Types of intraparenchymal hematoma as a predictor after revascularization in patients with anterior circulation acute ischemic stroke. Surg Neurol Int. 2021;17(12):102. DOI: 10.25259/SNI_792_2020</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ahn Y., Kim S.K., Baek B.H., Lee Y.Y., Lee H.J., Yoon W. Predictors of сcatastrophic outcome after endovascular thrombectomy in elderly patients with acute anterior circulation stroke. Korean J Radiol. 2020;21(1):101–7. DOI: 10.3348/kjr.2019.0431</mixed-citation><mixed-citation xml:lang="en">Ahn Y., Kim S.K., Baek B.H., Lee Y.Y., Lee H.J., Yoon W. Predictors of сcatastrophic outcome after endovascular thrombectomy in elderly patients with acute anterior circulation stroke. Korean J Radiol. 2020;21(1):101–7. DOI: 10.3348/kjr.2019.0431</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gębka M., Bajer-Czajkowska A., Pyza S., Safranow K., Poncyljusz W., Sawicki M. Evolution of hypodensity on non-contrast CT in Correlation with collaterals in anterior circulation stroke with successful endovascular reperfusion. J Clin Med. 2022;11(2):446. DOI: 10.3390/jcm11020446</mixed-citation><mixed-citation xml:lang="en">Gębka M., Bajer-Czajkowska A., Pyza S., Safranow K., Poncyljusz W., Sawicki M. Evolution of hypodensity on non-contrast CT in Correlation with collaterals in anterior circulation stroke with successful endovascular reperfusion. J Clin Med. 2022;11(2):446. DOI: 10.3390/jcm11020446</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ran J., Cui Y., Wang Y., Gu P. Relationship between fasting blood glucose and subsequent vascular events in Chinese patients with mild ischaemic stroke: a cohort study. J Int Med Res. 2021;49(5):30. DOI: 10.1177/03000605211019645</mixed-citation><mixed-citation xml:lang="en">Ran J., Cui Y., Wang Y., Gu P. Relationship between fasting blood glucose and subsequent vascular events in Chinese patients with mild ischaemic stroke: a cohort study. J Int Med Res. 2021;49(5):30. DOI: 10.1177/03000605211019645</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y., Gu S., Wang C., Liu D., Zhang Q., Yang M., et al. Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China. BMJ Open. 2021;11(8):234. DOI: 10.1136/bmjopen-2021-050234</mixed-citation><mixed-citation xml:lang="en">Zhang Y., Gu S., Wang C., Liu D., Zhang Q., Yang M., et al. Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China. BMJ Open. 2021;11(8):234. DOI: 10.1136/bmjopen-2021-050234</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zubair A.S., Sheth K.N. Hemorrhagic conversion of acute ischemic stroke. Neurotherapeutics. 2023;20(3):705–11. DOI: 10.1007/s13311-023-01377-1</mixed-citation><mixed-citation xml:lang="en">Zubair A.S., Sheth K.N. Hemorrhagic conversion of acute ischemic stroke. Neurotherapeutics. 2023;20(3):705–11. DOI: 10.1007/s13311-023-01377-1</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Silverman A., Kodali S., Sheth K.N., Petersen N.H. Hemodynamics and hemorrhagic transformation after endovascular therapy for ischemic stroke. Front Neurol. 2020;11:728. DOI: 10.3389/fneur.2020.00728</mixed-citation><mixed-citation xml:lang="en">Silverman A., Kodali S., Sheth K.N., Petersen N.H. Hemodynamics and hemorrhagic transformation after endovascular therapy for ischemic stroke. Front Neurol. 2020;11:728. DOI: 10.3389/fneur.2020.00728</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
