<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgonco</journal-id><journal-title-group><journal-title xml:lang="ru">Креативная хирургия и онкология</journal-title><trans-title-group xml:lang="en"><trans-title>Creative surgery and oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-3093</issn><issn pub-type="epub">2307-0501</issn><publisher><publisher-name>Башкирский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24060/2076-3093-2023-13-4-342-347</article-id><article-id custom-type="elpub" pub-id-type="custom">surgonco-866</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Клинический случай стентирования коронарной артерии под контролем ВСУЗИ у больного с хронической почечной недостаточностью</article-title><trans-title-group xml:lang="en"><trans-title>Clinical Case of IVUS-Guided Coronary Artery Stenting in a Patient with Chronic Renal Failure</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2602-5006</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильев</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasiliev</surname><given-names>D. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васильев Дмитрий Константинович — м.н.с., отдел инновационных методов профилактики, диагностики и лечения сердечно-сосудистых и других хронических неинфекционных заболеваний,  отделение рентгенэндоваскулярных методов диагностики и лечения</p><p>Москва</p></bio><bio xml:lang="en"><p>Dmitry K. Vasiliev — Junior Research Assistant, Unit of Innovative Methods for the Prevention, Diagnosis and Treatment of Cardiovascular and Other Chronic Noncommunicable Diseases, Unit of X-ray Endovascular Methods of Diagnosis and Treatment</p><p>Moscow</p></bio><email xlink:type="simple">vasilyevdk@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0346-9069</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руденко</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudenko</surname><given-names>B. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Руденко Борис Александрович — д.м.н., отдел инновационных методов профилактики, диагностики  и лечения сердечно-сосудистых и других  хронических неинфекционных заболеваний, отделение  рентгенэндоваскулярных методов диагностики и лечения</p><p>Москва</p></bio><bio xml:lang="en"><p>Boris A. Rudenko — Dr. Sci. (Med.), Unit of Innovative Methods for the Prevention, Diagnosis and Treatment of Cardiovascular and Other Chronic Noncommunicable Diseases, Unit of X-ray Endovascular Methods of Diagnosis and Treatment</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3851-4544</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фещенко</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Feshchenko</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фещенко Дарья Анатольевна — отделение рентгенэндоваскулярных методов диагностики и лечения, операционный блок</p><p>Москва</p></bio><bio xml:lang="en"><p>Daria A. Feshchenko — Unit of X-ray Endovascular  Methods of Diagnosis and Treatment, Operating Room</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7307-1502</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шукуров</surname><given-names>Ф. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Shukurov</surname><given-names>F. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шукуров Фирдавс Баходурович — отделение  рентгенэндоваскулярных методов диагностики и лечения</p><p>Москва</p></bio><bio xml:lang="en"><p>Firdavs B. Shukurov — Unit of X-ray Endovascular  Methods of Diagnosis and Treatment</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3119-6758</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаноян</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shanoyan</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шаноян Артем Сергеевич — к.м.н., отделение рентгенхирургических методов диагностики и лечения</p><p>Москва</p></bio><bio xml:lang="en"><p>Artem S. Shanoyan — Cand. Sci. (Med.), Unit of X-ray Surgical Methods of Diagnosis and Treatment</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр терапии и профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2023</year></pub-date><volume>13</volume><issue>4</issue><fpage>342</fpage><lpage>347</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васильев Д.К., Руденко Б.А., Фещенко Д.А., Шукуров Ф.Б., Шаноян А.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Васильев Д.К., Руденко Б.А., Фещенко Д.А., Шукуров Ф.Б., Шаноян А.С.</copyright-holder><copyright-holder xml:lang="en">Vasiliev D.K., Rudenko B.A., Feshchenko D.A., Shukurov F.B., Shanoyan A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgonco.ru/jour/article/view/866">https://www.surgonco.ru/jour/article/view/866</self-uri><abstract><p>Введение. В условиях расширения показаний к ЧКВ у больных ишемической болезнью сердца с тяжелой сопутствующей патологией растет число пациентов с хронической почечной недостаточностью. КИН является одним из грозных осложнений, что не только усугубляет течение основного заболевания, но и уменьшает продолжительность жизни больного. Современные методы внутрисосудистой визуализации широко внедряются в реальную клиническую практику эндоваскулярной хирургии. В условиях растущего числа выполняемых ЧКВ у больных с тяжелой сопутствующей патологией использование ВСУЗИ улучшит не только качество выполняемых стентирований, но и снизит риски развития КИН ввиду уменьшения объема вводимого контраста. Материалы и методы. Приводим клинический случай стентирования правой коронарной артерии без использования контрастного вещества под контролем ВСУЗИ у пациентки с хронической болезнью почек и диагнозом: Ишемическая болезнь сердца. Стенокардия напряжения, III функциональный класс (одышка как эквивалент). Баллонная ангиопластика и стентирование ОВ и ПМЖВ. Гиперлипидемия 2 а. Атеросклероз аорты, брахиоцефальных и коронарных артерий. Гипертоническая болезнь III стадии. Контролируемая артериальная гипертензия. Риск ССО IV. Сахарный диабет 2 типа. Целевой уровень гликированного гемоглобина менее 7,5 %. Ожирение 2 степени, экзогенно-конституциональное. Микролиты почек. ХБП 4 стадия (СКФ 29 мл/мин/1,73 м 2). Цереброваскулярная болезнь. Хроническая ишемия головного мозга. Результаты и обсуждение. В описанном клиническом случае удалось добиться полной реваскуляризации миокарда под контролем ВСУЗИ с использованием минимального количества контрастного препарата у больного с тяжелой ХПН Данный клинический пример демонстрирует преимущество малоинвазивных эндоваскулярных вмешательств у сложной категории больных, которые позволят расширить возможности оказания высокотехнологичной помощи больным, имеющим значительные ограничения в применении контрастных препаратов ввиду тяжелой ХПН с высоким риском развития КИН. Заключение. На сегодняшний день все большее количество рентгеноперационных страны оснащены внутрисосудистыми модальностями, что, безусловно, приведет к более широкому их применению. Навыки и знания применения ВСУЗИ позволят в меньшем объеме использовать РКП, что приведет к снижению риска развития КИН и, как следствие, улучшению прогноза пациентов со сниженной функцией почек и высоким риском КИН.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. An expanding number of indications for PCI in patients with coronary heart disease and severe concomitant pathology are accompanied by a growing number of patients with chronic renal failure. Contrast-induced nephropathy (CIN) is recognized as a severe complication, aggravating the course of the underlying disease, and, moreover, reducing the life expectancy of the patients. Modern intravascular imaging technologies are widely implemented in real clinical practice of endovascular surgery. In the context of increasing number of PCI performed in patients with severe concomitant pathology, the IVUS-guidance will improve the quality of stenting, and, importantly, lessen the risks of CIN due to the reduction in contrast volume. Materials and methods. The paper presents a clinical case of IVUSguided stenting of the right coronary artery without contrast agent in a patient with chronic kidney disease and the following diagnosis: “Coronary heart disease. Effort angina, class III (dyspnea as anginal equivalent). Balloon angioplasty and stenting of circumflex artery and LAD. Hyperlipidemia 2a. Atherosclerosis of the aorta, brachiocephalic and coronary arteries. Stage 3 hypertension. Controlled Hypertension. Level IV CVD risk. Type 2 diabetes mellitus. Target glycated hemoglobin is less than 7.5%. Grade 2 obesity, exogenous-constitutional. Renal microlithiasis. CKD stage 4 (GFR 29 ml/min/1.73m2). Cerebrovascular disease. Chronic cerebral ischemia.” Results and discussion. In the described clinical case, a complete myocardial revascularization was achieved using IVUS-guidance and minimal amount of contrast agent in a patient with severe CKD. The advantage of minimally invasive endovascular interventions in a complex category of patients, demonstrated by the case, implies expanded possibilities for providing high-tech care to patients with significant limitations in the use of contrast agents due to severe CKD with a high risk of CIN. Conclusion. Today, an increasing number of X-ray operating rooms in Russia are equipped with intravascular technologies, ensuring their wider use. The skills and knowledge in using IVUS imply rare application of contrast agents, thereby lessening the risk of CKD and, as a consequence, improving the prognosis of patients with reduced renal function and high risk of CKD.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>чрескожное коронарное вмешательство</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>хроническая болезнь почек</kwd><kwd>внутрисосудистый ультразвук</kwd><kwd>контрастные вещества</kwd><kwd>контраст-индуцированная нефропатия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>percutaneous coronary intervention</kwd><kwd>coronary heart disease</kwd><kwd>chronic kidney disease</kwd><kwd>intravascular ultrasound</kwd><kwd>contrast media</kwd><kwd>contrast-induced nephropathy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алекян Б.Г., Григорьян А.М., Стаферов А.В., Карапетян Н.Г. Рентгенэндоваскулярная диагностика и лечение заболеваний сердца и сосудов в Российской Федерации — 2020 год. Эндоваскулярная хирургия. 2021;8(Спец. вып.):S5–248. DOI: 10.24183/2409-4080-2021-8S-S5-S248</mixed-citation><mixed-citation xml:lang="en">Alekyan B.G., Grigoryan A.M., Staferov A.V., Karapetyan N.G. Endovascular diagnostics and treatment in the Russian Federation (2020). Russian Journal of Endovascular Surgery. 2021;(S8):S5–248 (In Russ.). DOI: 10.24183/2409-4080-2021-8S-S5-S248</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sarnak M.J., Amann K., Bangalore S., Cavalcante J.L., Charytan D.M., Craig J.C., et al. Chronic kidney disease and coronary artery disease: JACC state-of-the-art review. J Am Coll Cardiol. 2019;74(14):1823–38. DOI: 10.1016/j.jacc.2019.08.1017</mixed-citation><mixed-citation xml:lang="en">Sarnak M.J., Amann K., Bangalore S., Cavalcante J.L., Charytan D.M., Craig J.C., et al. Chronic kidney disease and coronary artery disease: JACC state-of-the-art review. J Am Coll Cardiol. 2019;74(14):1823–38. DOI: 10.1016/j.jacc.2019.08.1017</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Дунаева А.Р., Щербакова А.С., Хафизов Е.Н., Загидуллин Н.Ш. Контраст-индуцированная нефропатия при коронарографии. Практическая медицина. 2014;3(79):35–40.</mixed-citation><mixed-citation xml:lang="en">Dunaeva A.R., Shcherbakova A.S., Khafizov T.N., Zagidullin N.Sh. Contrast-induced nephropathy after coronary angiography. Practical medicine. 2014;3(79):35–40 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Holzmann M.J., Siddiqui A.J. Outcome of percutaneous coronary intervention during non-ST-segment-elevation myocardial infarction in elderly patients with chronic kidney disease. J Am Heart Assoc. 2020;9(12):e015084. DOI: 10.1161/JAHA.119.015084</mixed-citation><mixed-citation xml:lang="en">Holzmann M.J., Siddiqui A.J. Outcome of percutaneous coronary intervention during non-ST-segment-elevation myocardial infarction in elderly patients with chronic kidney disease. J Am Heart Assoc. 2020;9(12):e015084. DOI: 10.1161/JAHA.119.015084</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta T., Paul N., Kolte D., Harikrishnan P., Khera S., Aronow W.S., et al. Association of chronic renal insufficiency with in-hospital outcomes after percutaneous coronary intervention. J Am Heart Assoc. 2015;4(6):e002069. DOI: 10.1161/JAHA.115.002069</mixed-citation><mixed-citation xml:lang="en">Gupta T., Paul N., Kolte D., Harikrishnan P., Khera S., Aronow W.S., et al. Association of chronic renal insufficiency with in-hospital outcomes after percutaneous coronary intervention. J Am Heart Assoc. 2015;4(6):e002069. DOI: 10.1161/JAHA.115.002069</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Guo W., Song F., Chen S., Zhang L., Sun G., Liu J., et al. The relationship between hyperuricemia and contrast-induced acute kidney injury undergoing primary percutaneous coronary intervention: secondary analysis protocol for the ATTEMPT RESCIND-1 study. Trials. 2020;21(1):567. DOI: 10.1186/s13063-020-04505-w</mixed-citation><mixed-citation xml:lang="en">Guo W., Song F., Chen S., Zhang L., Sun G., Liu J., et al. The relationship between hyperuricemia and contrast-induced acute kidney injury undergoing primary percutaneous coronary intervention: secondary analysis protocol for the ATTEMPT RESCIND-1 study. Trials. 2020;21(1):567. DOI: 10.1186/s13063-020-04505-w</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sun G., Chen P., Wang K., Li H., Chen S., Liu J., et al. Contrast-induced nephropathy and long-term mortality after percutaneous coronary intervention in patients with acute myocardial infarction. Angiology. 2019;70(7):621–6. DOI: 10.1177/0003319718803677</mixed-citation><mixed-citation xml:lang="en">Sun G., Chen P., Wang K., Li H., Chen S., Liu J., et al. Contrast-induced nephropathy and long-term mortality after percutaneous coronary intervention in patients with acute myocardial infarction. Angiology. 2019;70(7):621–6. DOI: 10.1177/0003319718803677</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Faucon A.L., Bobrie G., Clément O. Nephrotoxicity of iodinated contrast media: From pathophysiology to prevention strategies. Eur J Radiol. 2019;116:231–41. DOI: 10.1016/j.ejrad.2019.03.008</mixed-citation><mixed-citation xml:lang="en">Faucon A.L., Bobrie G., Clément O. Nephrotoxicity of iodinated contrast media: From pathophysiology to prevention strategies. Eur J Radiol. 2019;116:231–41. DOI: 10.1016/j.ejrad.2019.03.008</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120(4):c179–84. DOI: 10.1159/000339789</mixed-citation><mixed-citation xml:lang="en">Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120(4):c179–84. DOI: 10.1159/000339789</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rihal C.S., Textor S.C., Grill D.E., Berger P.B., Ting H.H., Best P.J., et al. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation. 2002;105(19):2259–64. DOI: 10.1161/01.cir.0000016043.87291.33</mixed-citation><mixed-citation xml:lang="en">Rihal C.S., Textor S.C., Grill D.E., Berger P.B., Ting H.H., Best P.J., et al. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation. 2002;105(19):2259–64. DOI: 10.1161/01.cir.0000016043.87291.33</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mehran R., Aymong E.D., Nikolsky E., Lasic Z., Iakovou I., Fahy M., et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004;44(7):1393–9. DOI: 10.1016/j.jacc.2004.06.068</mixed-citation><mixed-citation xml:lang="en">Mehran R., Aymong E.D., Nikolsky E., Lasic Z., Iakovou I., Fahy M., et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004;44(7):1393–9. DOI: 10.1016/j.jacc.2004.06.068</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hoste E.A., De Waele J.J., Gevaert S.A., Uchino S., Kellum J.A. Sodium bicarbonate for prevention of contrast-induced acute kidney injury: a systematic review and meta-analysis. Nephrol Dial Transplant. 2010;25(3):747–58. DOI: 10.1093/ndt/gfp389</mixed-citation><mixed-citation xml:lang="en">Hoste E.A., De Waele J.J., Gevaert S.A., Uchino S., Kellum J.A. Sodium bicarbonate for prevention of contrast-induced acute kidney injury: a systematic review and meta-analysis. Nephrol Dial Transplant. 2010;25(3):747–58. DOI: 10.1093/ndt/gfp389</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rufino Hernández J.M., Zamora Rodríguez N., Rodríguez Adanero C., Lorenzo Sellares V., Torres A. Acute renal failure in a tertiary referal hospital, a relevant cause of chronic renal failure and mortality. Nefrologia. 2017;37(6):657–8. DOI: 10.1016/j.nefro.2017.03.008</mixed-citation><mixed-citation xml:lang="en">Rufino Hernández J.M., Zamora Rodríguez N., Rodríguez Adanero C., Lorenzo Sellares V., Torres A. Acute renal failure in a tertiary referal hospital, a relevant cause of chronic renal failure and mortality. Nefrologia. 2017;37(6):657–8. DOI: 10.1016/j.nefro.2017.03.008</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ikizler T.A., Parikh C.R., Himmelfarb J., Chinchilli V.M., Liu K.D., Coca S.G., et al. A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death. Kidney Int. 2021;99(2):456–65. DOI: 10.1016/j.kint.2020.06.032</mixed-citation><mixed-citation xml:lang="en">Ikizler T.A., Parikh C.R., Himmelfarb J., Chinchilli V.M., Liu K.D., Coca S.G., et al. A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death. Kidney Int. 2021;99(2):456–65. DOI: 10.1016/j.kint.2020.06.032</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ronco F., Tarantini G., McCullough P.A. Contrast induced acute kidney injury in interventional cardiology: an update and key guidance for clinicians. Rev Cardiovasc Med. 2020;21(1):9–23. DOI: 10.31083/j.rcm.2020.01.44</mixed-citation><mixed-citation xml:lang="en">Ronco F., Tarantini G., McCullough P.A. Contrast induced acute kidney injury in interventional cardiology: an update and key guidance for clinicians. Rev Cardiovasc Med. 2020;21(1):9–23. DOI: 10.31083/j.rcm.2020.01.44</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
