Mucinous Adenocarcinoma of the Right Lung in a Child: Clinical case
https://doi.org/10.24060/2076-3093-2025-15-4-384-389
Abstract
Introduction. Lung cancer in children is an extremely rare pathology occurring in less than 0.2 % of all childhood tumors. The most frequently detected tumors are adenocarcinoma and carcinoid tumors, which are often diagnosed at late stages due to the lack of specific symptoms and difficulties in differential diagnosis. Materials and methods. The article presents a clinical case of invasive mucinous adenocarcinoma of the lung in a 9-year-old child. Results. The tumor was incidentally found during a chest computed tomography scan. Changes in the lungs were assessed as destructive pneumonia, for which the patient received long-term treatment resulted in clinical improvement. However, a control computed tomography scan revealed negative dynamics. Given the localization of changes in one lobe, the patient underwent an upper lobectomy with systematic mediastinal lymph node dissection after preoperative preparation. Histologically, the diagnosis was invasive mucinous adenocarcinoma of the lung. No specific antitumor treatment was administered. The patient is currently under dynamic observation without signs of relapse. Discussion. This clinical case demonstrates the problems of diagnosing lung cancer in children, as well as the problems of staging the disease and determining treatment tactics. Conclusion. The performed study emphasizes the need to develop clear clinical guidelines for the diagnosis and treatment of lung cancer in children, taking into account anatomical and physiological characteristics of the child’s body.
About the Authors
M. V. KobelevRussian Federation
Maksim V. Kobelev — Cand. Sci. (Med.), Surgery Thoracic Unit No. 1, Department of Respiratory Medicine with a course in Radiology
Tyumen
N. A. Mashkina
Russian Federation
Natalia A. Mashkina — Surgery Thoracic Unit No. 2
Tyumen
I. B. Popov
Russian Federation
Ivan B. Popov — Cand. Sci. (Med.), Surgery Thoracic Unit No. 1, Department of Respiratory Medicine with a course in Radiology
Tyumen
A. S. Kobeleva
Russian Federation
Anna S. Kobeleva — Surgery Thoracic Unit No. 1
Tyumen
D. V. Buryi
Russian Federation
Denis V. Buryi — Surgery Thoracic Unit No. 2
Tyumen
A. S. Abgaryan
Russian Federation
Artem S. Abgaryan — Surgery Thoracic Unit No. 1
Tyumen
References
1. Zabolotskikh T.V., Babenko A.A., Grigorenko G.V., Medvedeva S.V., Kharchenko M.V. Clinical case of mucinous invasive adenocarcinoma of the lung in an adolescent. Russian Bulletin of Perinatology and Pediatrics. 2025;70(3):95–9 (In Russ.). DOI: 10.21508/1027-4065-2025-70-3-95-99
2. Chen Q., Cheng J., Wang L., Lv X., Hu J. Primary lung cancer in children and adolescents. J Cancer Res Clin Oncol. 2024;150(5):225. DOI: 10.1007/s00432-024-05750-1
3. Abele M., Bajčiová V., Wright F., Behjati S., Voggel S., Schneider D.T., et al. Primary lung carcinoma in children and adolescents: An analysis of the European Cooperative Study Group on Paediatric Rare Tumours (EXPeRT). Eur J Cancer. 2022;175:19–30. DOI: 10.1016/j.ejca.2022.08.007
4. Chen W., Bai J., Fang Y., Wu D., Zhang B. Prognostic factors and surgical management in pediatric primary lung cancer: a retrospective cohort study using SEER data. Transl Pediatr. 2024;13(10):1671–83. DOI: 10.21037/tp-24-174
5. Balzer B.W.R., Loo C., Lewis C.R., Trahair T.N., Anazodo A.C. Adenocarcinoma of the Lung in Childhood and Adolescence: A Systematic Review. J Thorac Oncol. 2018;13(12):1832–41. DOI: 10.1016/j.jtho.2018.08.2020
6. De Martino L., Errico M.E., Ruotolo S., Cascone D., Chiaravalli S., Collini P., et al. Pediatric lung adenocarcinoma presenting with brain metastasis: a case report. J Med Case Rep. 2018;12(1):243. DOI: 10.1186/s13256-018-1781-1
7. Borgia P., Cafferata B., Paratore C., Anfigeno L., Conte A., Florio A., et al. Primary lung tumors in children: insights from a single-center case series. J Clin Med. 2025;14(7):2173. DOI: 10.3390/jcm14072173
8. Gumbatova E.D. Metastatic lung disease in children with solid tumors: a historical excursion. Russian Journal of Pediatric Hematology аnd Oncology 2019;6(1):56–60 (In Russ.). DOI: 10.17650/2311-1267-2019-6-1-56-60
9. Koh J., Jung E., Jang S.J., Kim D.K., Lee B.S., Kim K.S., et al. Case of mucinous adenocarcinoma of the lung associated with congenital pulmonary airway malformation in a neonate. Korean J Pediatr. 2018;61(1):30–4. DOI: 10.3345/kjp.2018.61.1.30
10. Ge L., Wang L., Pei D. Pulmonary mucinous adenocarcinoma: An overview of pathophysiology and advancements in treatment. Heliyon. 2024;10(9):e28881. DOI: 10.1016/j.heliyon.2024.e28881
11. Buettner R. Invasive mucinous adenocarcinoma: genetic insights into a lung cancer entity with distinct clinical behavior and genomic features. Mod Pathol. 2022;35(2):138–9. DOI: 10.1038/s41379-021-00945-0
12. Huang F., Wang H., Qiao R., Ganti A.K., Kudo Y., Zhang Y., et al. Prognostic analysis and development of a predictive model for pulmonary invasive mucinous adenocarcinoma. J Thorac Dis. 2025;17(7):5146–63. DOI: 10.21037/jtd-2025-755
13. Zhou P., Zhaxi C., Jiang L. A unique case of pulmonary minimally invasive mucinous adenocarcinoma arising from atypical goblet cell hyperplasia in the bronchial epithelium of a 9-year-old girl. BMC Pediatr. 2025;25(1):333. DOI: 10.1186/s12887-025-05683-9
14. Türüt H., Demirag F., Gulhan E., Tastepe I. Primary pulmonary mucinous adenocarcinoma in a 15-year-old boy. Eur J Cardiothorac Surg. 2006;29(5):851–3. DOI: 10.1016/j.ejcts.2006.01.051
15. Bontsevich R.A., Khamitova A.A., Danilova M.S., Zavitkevich G.I., Gavrilov P.V. Diffuse Form of Adenocarcinoma under the Guise of Pneumonia. Challenges in Modern Medicine. 2025;48(2):134–145 (In Russ.). DOI: 10.52575/2687-0940-2025-48-2-134-145.
16. Huo J.W., Huang X.T., Li X., Gong J.W., Luo T.Y., Li Q. Pneumonictype lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics. Insights Imaging. 2021;12(1):169. DOI: 10.1186/s13244-021-01114-2
17. Zhang S., Yu X., Huang Y., Nie P., Deng Y., Mao N., et al. Pneumonic type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers. BMC Pulm Med. 2022;22(1):460. DOI: 10.1186/s12890-022-02268-5
18. Yang Y., Huang R., Xiang L., Zeng J., Zhao W., Huang N. Invasive mucinous adenocarcinoma misdiagnosed as pneumonia: A case report. Exp Ther Med. 2023;25(4):168. DOI: 10.3892/etm.2023.11867
19. Zhu D., Zhang Q., Rui Z., Xu S. Pulmonary invasive mucinous adenocarcinoma mimicking pulmonary actinomycosis. BMC Pulm Med. 2022;22(1):181. DOI: 10.1186/s12890-022-01971-7
20. Laktionov K.K., Artamonova E.V., Borisova T.N., Breder V.V., Bychkov I.M., Vladimirova L.I., et al. Malignant neoplasm of the bronchi and lung: Russian clinical guidelines. Journal of Modern Oncology. 2021;23(3):369–402 (In Russ.). DOI: 10.26442/18151434.2021.3.201048
Review
For citations:
Kobelev M.V., Mashkina N.A., Popov I.B., Kobeleva A.S., Buryi D.V., Abgaryan A.S. Mucinous Adenocarcinoma of the Right Lung in a Child: Clinical case. Creative surgery and oncology. 2025;15(4):384-389. (In Russ.) https://doi.org/10.24060/2076-3093-2025-15-4-384-389


























