Effects of Microcirculation Disorders on the Development of Postoperative Complications in Abdominal Surgery
https://doi.org/10.24060/2076-3093-2025-15-4-402-414
Abstract
Postoperative complications represent a pressing issue of clinical medicine, worsening the prognosis and increasing the risk of death in surgical patients, especially in abdominal and oncological surgery. According to contemporary concepts, microcirculatory dysfunction appears to be an important pathophysiological factor underlying tissue hypoperfusion and development of unfavorable postoperative outcomes. The present review summarizes current data on the relationship between microcirculation disorders both in the surgical area and body as a whole and postoperative complications of abdominal surgery. The review addresses the following issues: (1) epidemiology of postoperative complications and its relevance in clinical surgery and resuscitation; (2) pathophysiology of perioperative microcirculatory disorders, including hemorrhagic shock, disseminated intravascular coagulation (DIC) and endothelial dysfunction; (3) organ-specific changes in microcirculation in surgical diseases; (4) contemporary diagnostic and monitoring methods for tissue perfusion assessment; (5) prognostic and diagnostic value of a number of microcirculation parameters; (6) contemporary therapeutic approaches to tissue perfusion optimization and complication prevention. Understanding the important role of microcirculation in ensuring tissue perfusion and oxygenation justifies the use of intensive care methods focused on microcirculation and thus the prevention of organ ischemia, infectious and other postoperative complications.
About the Authors
I. A. Ryzhkov
V.A. Negovskiy Scientific Research Institute of General Resuscitation, Federal Scientific and Clinical Centre of Intensive Care Medicine and Rehabilitology
Russian Federation
Russian Federation
Ivan A. Ryzhkov — Cand. Sci. (Med.), Leading Researcher, Laboratory of Experimental Research
Moscow
L. A. Varnakova
V.A. Negovskiy Scientific Research Institute of General Resuscitation, Federal Scientific and Clinical Centre of Intensive Care Medicine and Rehabilitology
Russian Federation
Russian Federation
Lidia A. Varnakova — Junior Researcher, Laboratory of Experimental Research
Moscow
P. A. Fonova
V.A. Negovskiy Scientific Research Institute of General Resuscitation, Federal Scientific and Clinical Centre of Intensive Care Medicine and Rehabilitology
Russian Federation
Russian Federation
Polina A. Fonova — Junior Researcher, Laboratory of Experimental Research
Moscow
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Ryzhkov I.A., Varnakova L.A., Fonova P.A. Effects of Microcirculation Disorders on the Development of Postoperative Complications in Abdominal Surgery. Creative surgery and oncology. 2025;15(4):402-414. (In Russ.) https://doi.org/10.24060/2076-3093-2025-15-4-402-414
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