THE LONG-TERM RESULTS OF OCCULT BREAST CARCINOMA TREATMENT
https://doi.org/10.24060/2076-3093-2014-0-1-2-17-21
Abstract
In breast cancer patients, axillary status continues to be the most powerful predictor of survival. This article contains retrospective and prospective analysis for 5-year survival, regional and distant recurrences of 35 patients with occult breast cancer (OBC) presenting as isolated axillary nodal metastasis TxN1-2M0 (I group) and 150 cases of node-positive palpable breast cancer (PBC) T1-3N1-2M0 (II group) during the period from 1997 to 2012 according the materials of Chelyabinsk regional oncology dispensary. The aim of this investigation is to compare prognoses of these groups patients after complex treatment to optimistic treating and diagnostic tactic of OBC. Five-year Kaplan-Meier estimate of overall survival among groups of our patients who had had lymph node metastasis status as N2 in I and II group had been allocated as 46,6% and 63,3% respectively (p=0,02). Five-year distant recurrences of disease among groups of our patients who had had lymph node metastasis status as N2 in I and II group had been allocated as 66,6% and 51,6% respectively (p=0,04). The differences observed between patients of these groups were statistically significant. The OBC prognosis is worse than PBC in N2 subgroup that demand more aggressive therapy for patients of I group.
References
1. Комаров И.Г., Комов Д.В. Метастазы злокачественной опухоли без выявленного первичного очага. - М.: «Триада-Х», 2002. - С. 37-55.
2. Blanchard D. Retrospective study of women presenting with axillary metastases from occult breast carcinoma / D. Blanchard, D. Farley // World J. Surg. - 2004. - Vol. 28. - P. 535-539.
3. Presentation of axillary lymphadenopathy without detectable breast primary (T0N1b breast cancer): experience at Institut Curie / F. Campana, A. Fourguet, M. Ashby et al. // Radiother Oncol. -1989. - Vol. 15. - P. 321-325.
4. Foroudi F. Occult breast carcinoma presenting as axillary metastases / F. Foroudi, K.W. Tiver // Int. J. Radiat. Oncol. Biol. Phys. - 2000. - Vol. 47. - P. 143-147.
5. Clinical experience with axillary presentation breast cancer / V. Galimberti, G. Bassani, S. Monti et al. // Breast Cancer Res. Treat. - 2004. Vol. 88. - P. 43-47.
6. Hainsworth J. Management of patients with cancer of unknown primary site / J. Hainsworth, F. Greco // Oncology. 2000. Vol. 14. P. 563-579.
7. Clinicopathological characteristics of nonpalpable breast cancer presenting as axillary mass / T. Kyokane, S. Akashi-Tanaka, T. Matsui et al. // Breast Cancer. – 1995. - Vol. 2. - №2. - P. 105-112.
8. Cancer of unknown primary: changing approaches. A multidisciplinary case presentation from the Toan Karnell center of Pennsylvania Hospital / D. Mintzer, M. Warhol, A. Martin et al. // The Oncologist. - 2004. - Vol.
9. - №3. - P. 330-338. 9. Occult primary breast carcinoma presenting as axillary lymphadenopathy / C. Shannon, G. Walsh, F. Sapunar et al. // Breast. 2002. - Vol. 11. - P. 414-418.
10. Prognosis of occult breast carcinoma presenting as isolated axillary nodal metastasis / R. Varadarjan, S. Edge, J. Yu et al. // Oncology. - 2006. - Vol. 71. - P. 456-459. 11. Feasibility of breast preservation in the treatment of occult primary carcinoma presenting with axillary metastases / G. Vlastos, M. T
11. ean, A. Mizza et al. // Ann. Surg. Oncol. - 2001. - Vol. 8. - P. 425-431.
12. Population-based analysis of occult primary breast cancer with axillary lymph node metastasis / G. Walker, G. Smith, G. Perkins et al. // Cancer. 2010. - Vol. 116. - P. 4006-4006.
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For citations:
Kuklenko T.V. THE LONG-TERM RESULTS OF OCCULT BREAST CARCINOMA TREATMENT. Creative surgery and oncology. 2014;(1-2):17-21. (In Russ.) https://doi.org/10.24060/2076-3093-2014-0-1-2-17-21
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