Organ-on-a-chip Technology in Urology
https://doi.org/10.24060/2076-3093-2023-13-4-311-319
Abstract
Organs-on-chips (OOC) refer to microfluidic devices used to create biomimetic systems of physiological organs. The system contains engineered or natural miniature tissues grown inside microfluidic chips. Organ-on-a-chip technology enables numerous human pathologies to be reproduced, since classical animal models may fail to adequately predict the therapeutic response in humans. This technology can be an intermediate link in the animal-human research system. Moreover, in cancer studies, OOC simulate the three-dimensional hierarchical complexity of tumors in vivo and the tumor microenvironment, being an efficient and cost-effective solution for tumor growth studies and cancer drug screening. Organs-on-chips represent compact and easy-to-use microphysiological functional units simulating physical and biological processes in human body. This extends the possibility of preclinical studies, such as disease modeling or even the development of diagnostic devices. In this regard, the present study is aimed at reviewing the scientific literature in the field of microfluidic devices intended for use in urology and oncourology.
Keywords
organ-on-a-chip,
tumor-on-a-chip,
polymer microfluidic devices,
kidney-on-a-chip,
bladder-on-a-chip,
prostate-on-a-chip,
drug testing
Supporting agencies: This work was supported by the Bashkir State Medical University Strategic Academic Leadership Program (PRIORITY-2030).
About the Authors
A. G. Vardikian
Bashkir State Medical University;
Institute of Urology and Clinical Oncology, Bashkir State Medical University
Russian Federation
Russian Federation
Andranik G. Vardikian — Postgraduate Student, Department of Urology with a Course of Advanced Professional Education, Stem Cells Laborator
Ufa
S. V. Piatnitskaia
Bashkir State Medical University;
Institute of Fundamental Medicine, Bashkir State Medical University
Russian Federation
Russian Federation
Svetlana V. Piatnitskaia — Senior Research Assistant, Cell Culture Laboratory, Department of Internal Diseases
Ufa
V. A. Solntsev
Institute of Fundamental Medicine, Bashkir State Medical University
Russian Federation
Russian Federation
Vadim A. Solntsev — Medical Research Assistant, Cell Culture Laboratory
Ufa
B. I. Shamsov
Bashkir State Medical University
Russian Federation
Russian Federation
Bedil I. Shamsov — Postgraduate Student, Department of Urology with a Course of Advanced Professional Education
Ufa
V. N. Pavlov
Bashkir State Medical University;
Institute of Urology and Clinical Oncology, Bashkir State Medical University
Russian Federation
Russian Federation
Valentin N. Pavlov — Dr. Sci (Med.), Prof., Academician of the Russian Academy of Sciences, Department of Urology with a Course of Advanced Professional Education
Ufa
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Review
For citations:
Vardikian A.G., Piatnitskaia S.V., Solntsev V.A., Shamsov B.I., Pavlov V.N. Organ-on-a-chip Technology in Urology. Creative surgery and oncology. 2023;13(4):311-319. (In Russ.) https://doi.org/10.24060/2076-3093-2023-13-4-311-319
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