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Digital Cholangioscopy in Intrahepatic Cholelithiasis after Liver Transplantation: Clinical case

https://doi.org/10.24060/2076-3093-2025-15-4-376-383

Abstract

Introduction. Liver transplantation represents the definitive treatment for patients with end-stage liver disease. In liver transplant recipients, strictures of the biliary-digestive anastomosis and cholelithiasis of various localizations may occur. However, routine endoscopic procedures may be ineffective in some patients with complex forms of cholelithiasis and biliary strictures. In such situations, the SpyGlass DS™ direct digital cholangioscopy method is promising. Materials and methods. Clinical case: a 66-year-old patient in the late postoperative period after orthotopic related liver transplantation was diagnosed with a stricture of the reconstructive hepaticojejunostomy on the Roux-en-Y loop and intrahepatic cholelithiasis. The performed hybrid intervention includes: balloon dilation of the stricture and intrahepatic lithotripsy, lithoextraction using SpyGlass DS™ cholangioscopy, as well as percutaneous transhepatic drainage of the biliary tract under radiographic control. Results and discussion. Direct cholangioscopy ensured the safe elimination of hepatolithiasis and hepaticojejunostomy stricture in a patient after liver transplantation. External drainage with the possibility of delayed cholangiography was used to monitor the function of bile secretion with gradual replacement of drains. Conclusion. Direct digital cholangioscopy represents an important tool for the diagnosis and treatment of biliary complications in liver transplant recipients.

About the Authors

M. A. Nartailakov
Bashkir State Medical University
Russian Federation

Mazhit A. Nartailakov — Dr. Sci. (Med.), Prof., Department of General Surgery, Transplantology and X-ray Diagnostics

Ufa 



F. R. Nagaev
Bashkir State Medical University ; Clinic of Bashkir State Medical University
Russian Federation

Farit R. Nagaev — Surgery Unit, Department of General Surgery, Transplantology and X-ray Diagnostics

Ufa 



M. R. Bakeev
Bashkir State Medical University ; Clinic of Bashkir State Medical University
Russian Federation

Marat R. Bakeev — Resident, Department of Surgical Diseases, Faculty of Medicine, Surgery Unit

Ufa 



D. M. Minigalin
Bashkir State Medical University ; Clinic of Bashkir State Medical University
Russian Federation

Daniil M. Minigalin — Cand. Sci. (Med.), Department of Surgical Diseases, Faculty of Medicine, Surgery Unit

Ufa 



A. G. Safargalina
Bashkir State Medical University ; Clinic of Bashkir State Medical University
Russian Federation

Aygul G. Safargalina — Department of Surgical Diseases, Faculty of Medicine, Surgery Unit

Ufa 



References

1. Yoon S.B., Kim J., Paik C.N., Jang D.K., Lee J.K., Yoon W.J., et al. Endoscopic and Percutaneous Biliary Interventions after Liver Transplantation: Nationwide Data in Korea. Gut Liver. 2022;16(2):300–7. DOI: 10.5009/gnl20379

2. Duffy J.P., Kao K., Ko C.Y., Farmer D.G., McDiarmid S.V., Hong J.C., et al. Long-term patient outcome and quality of life after liver transplantation: analysis of 20-year survivors. Ann Surg. 2010;252:652–61. DOI: 10.1097/SLA.0b013e3181f5f23a

3. Jang S.I., Cho J.H., Lee D.K. Magnetic compression anastomosis for the treatment of post-transplant biliary stricture. Clin Endosc. 2020;53(3):266–75. DOI: 10.5946/ce.2020.095

4. Zhang C.C., Koschny R., Rupp C., Michl P., Mehrabi A., Wehling C., et al. Post-endoscopic retrograde cholangiopancreatography cholangitis after endoscopic treatment of post-transplant biliary strictures: a retrospective study. BMC Surg. 2025;25(1):353. DOI: 10.1186/s12893-025-03106-1

5. Ma M.X., Jayasekeran V., Chong A.K. Benign biliary strictures: prevalence, impact, and management strategies. Clin Exp Gastroenterol. 2019;12:83–92. DOI: 10.2147/CEG.S165016

6. Fodor M., Woerdehoff A., Peter W., Esser H., Oberhuber R., Margreiter C., et al. Reassessment of relevance and predictive value of parameters indicating early graft dysfunction in liver transplantation: AST is a weak, but bilirubin and INR strong predictors of mortality. Front Surg. 2021;8:693288. DOI: 10.3389/fsurg.2021.693288

7. Tripathi N., Mardini H., Koirala N., Raissi D., Emhmed Ali S.M., Frandah W.M. Assessing the utility, findings, and outcomes of percutaneous transhepatic cholangioscopy with SpyglassTM Direct visualization system: a case series. Transl Gastroenterol Hepatol. 2020;5:12. DOI: 10.21037/tgh.2019.11.11

8. Mishra S., Taneja S. Algorithmic approach to deranged liver functions after transplantation. J Clin Exp Hepatol. 2024;14(3):101317. DOI: 10.1016/j.jceh.2023.101317

9. Sung M.J., Jo J.H., Lee H.S., Park J.Y., Bang S., Park S.W., et al. Optimal drainage of anastomosis stricture after living donor liver transplantation. Surg Endosc. 2021;35(11):6307–17. DOI: 10.1007/s00464-021-08456-4

10. Rocha Fernandes Y., Visconti T.A.C., Dall’Agnol M.K., Ardengh A.O., Veras M.O., Valentim E.S.D.S., et al. Covered self-expanding metal stents versus multiple plastic stents in treating biliary strictures postorthotopic liver transplantation: a systematic review and meta-analysis of randomized controlled trials. DEN Open. 2025;6(1):e70143. DOI: 10.1002/deo2.70143

11. Çağın Y.F., Erdoğan M.A., Sağlam O., Yıldırım O., Bilgiç Y., Arslan A.K., et al. Optimal endoscopic management of anastomotic strictures after double- biliary reconstruction in right lobe living-donor liver transplantation. Balkan Med J. 2021;38(6):348–56. DOI: 10.5152/balkanmedj.2021.21692

12. Ataman E., Harputluoglu M., Bilgic Y., Cagin Y.F., Erdogan M.A., Kutlu R., et al. The course of endoscopic treatment success in biliary complications after living donor liver transplantation. Medeni Med J. 2024;39(1):33–8. DOI: 10.4274/MMJ.galenos.2024.89289

13. Jegadeesan M., Goyal N., Rastogi H., Gupta S. Percutaneous transhepatic biliary drainage for biliary stricture after endotherapy failure in living donor liver transplantation: a single-centre experience from India. J Clin Exp Hepatol. 2019;9(6):684–9. DOI: 10.1016/j.jceh.2019.03.004

14. Nartaylakov M.A., Sokolov S.V., Sokolov V.P., Gritsaenko A.I., Mukhamedyanov I.F., Risberg R.Yu. Analysis of complications of antegrade x-ray endovascular interventions in patients with obstructive jaundice. Bashkortostan Medical Journal. 2017;12(4):9–13 (In Russ.).

15. Büringer K., Schempf U., Fusco S., Wichmann D., Stüker D., Götz M., et al. Feasibility, safety and efficacy of endoscopic single-operator cholangioscopy: a retrospective single-center study. Therap Adv Gastroenterol. 2024;17:17562848241288111. DOI: 10.1177/17562848241288111

16. Tu Q.Y., Li D.L., Liu D., Zheng Q.F., Liu B.R. Choledocholithotripsy using peroral direct cholangioscopy through a standard gastroscope for a giant common bile duct stone: a case report. Gastroenterol Rep (Oxf). 2024;30(4):goae014. DOI: 10.1093/gastro/goae014

17. Chon H.K., Choi K.H., Seo S.H., Kim T.H. Efficacy and safety of percutaneous transhepatic cholangioscopy with the spyglass DS direct visualization system in patients with surgically altered anatomy: a pilot study. Gut Liver. 2022;16(1):111–7. DOI: 10.5009/gnl210028

18. Singh P., Singla V., Goel A., Shawl M.R., Bashir S. Percutaneous cholangioscopy-assisted rendezvous endoscopic retrograde cholangiography technique for a difficult postliver transplant anastomotic stricture. VideoGIE. 2025;10(8):402–5. DOI: 10.1016/j.vgie.2025.03.025

19. Zhang W., Sun H., Dong D., Li Y. Safety and feasibility of a novel recanalization technique using guidewire puncture under cholangioscopy for complete biliary stricture after liver transplantation. Sci Rep. 2023;13(1):4874. DOI: 10.1038/s41598-023-31475-1

20. Balderramo D., Sendino O., Miquel R., de Miguel C.R., Bordas J.M., Martinez-Palli G., et al. Prospective evaluation of single-operator peroral cholangioscopy in liver transplant recipients requiring an evaluation of the biliary tract. Liver Transpl. 2013;19:199–206. DOI: 10.1002/lt.23585

21. Jang S.I., Fang S., Nahm J.H., Cho J.H., Do M.Y., Lee S.Y., et al. Preclinical evaluation of endoscopic placement of a steroid-eluting metal stent in an in vivo porcine benign biliary stricture model. Sci Rep. 2022;12(1):8864. DOI: 10.1038/s41598-022-12957-0

22. Yasen A., Feng J., Liang R.B., Zhu C.H., Li J., Liu A.Z., et al. Efficiency of percutaneous transhepatic cholangioscopy in the treatment of biliary complications after liver transplantation. HPB (Oxford). 2023;25(4):463–71. DOI: 10.1016/j.hpb.2023.01.010

23. Stadmeyer P., Dalvie P., Hubers J., Gopal D. Percutaneous transhepatic single-operator cholangioscopy-guided intraductal stone therapy in a liver transplant patient with ischemic cholangiopathy. ACG Case Rep J. 2021;8(6):e00595. DOI: 10.14309/crj.0000000000000595

24. Clarete A., Nasner D., Toro-Gutiérrez J.S., Holguín-Holguín A. Successful application of percutaneous endoscopic cholangioscopy + electrohydraulic lithotripsy for hepatolithiasis post-liver transplantation: a case report. J Med Case Rep. 2024;18(1):472. DOI: 10.1186/s13256-024-04669-y

25. Funari M.P., Hirsch B.S., Franzini T.P., de Moura D.T.H., Miranda Neto A.A., McCarty T.R., et al. Role of cholangioscopy and therapeutic options in complex anastomotic strictures after liver transplantation. Endoscopy. 2022;54(10):E581–2. DOI: 10.1055/a-1704-7503

26. Guillén Graf A.M., Reyna Aréchiga A.I., Escareño Pérez C.E., BosquesPadilla F., Jáquez Quintana J.O. Digital single-operator cholangioscopy in the evaluation of biliary strictures after liver transplantation. Rev Esp Enferm Dig. 2024 Sep 13. DOI: 10.17235/reed.2024.10708/2024


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For citations:


Nartailakov M.A., Nagaev F.R., Bakeev M.R., Minigalin D.M., Safargalina A.G. Digital Cholangioscopy in Intrahepatic Cholelithiasis after Liver Transplantation: Clinical case. Creative surgery and oncology. 2025;15(4):376-383. (In Russ.) https://doi.org/10.24060/2076-3093-2025-15-4-376-383

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ISSN 2076-3093 (Print)
ISSN 2307-0501 (Online)