CLINICAL COURSE OF VULVAR CANCER IN REPRODUCTIVE PATIENTS

Abstract

Incidence  of vulvar cancer  in reproductive patients and  peculiarities  of clinical course of the disease  have been  studied. 839  vulvar cancer  patients aged  20-90 years have been treated at Gynecology Department of Rostov Research Oncologic Institute within the latest 30 years. The reproductive group  (20-50 years of age)  included 64 patients (7,6%). Early stages of vulvar cancer in the reproductive group were diagnosed more often than in elderly patients. Neurodystrophic changes of vulvar in young patients were much rarely observed in comparison with elderly patients. Almost 80% of patients under 40 years of age had human papilloma  virus; in the  group  of 41-50  years of age  – 50%; whereas in the  elderly group contamination with  human papilloma  virus was  observed only in single cases  – 0,48%. Organ-sparing operations performed by strict individual approach are possible in the group of young  patients. Vulvar cancer, in particular with advanced malignant process, requires complex   treatment  including   neoadjuvant  and   multi-course adjuvant  chemotherapy. Recurrent disease in reproductive patients is observed less frequent than in elderly patients. Chemotherapy is appropriate in cases of recurrent disease in order to improve  operability.