THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON
https://doi.org/10.24060/2076-3093-2013-0-3-52-57
Abstract
The results of treatment of 14 patients with gastric cancer with metastases to the bones of the skeleton were analized, which was conducted by the stabilization of metastatic spine vertebroplasty, systemic radionuclide therapy with samarium-153 oksabifor and intravenous infusion by Zolendronic acid 4 mg 1 time in 28 days. When applying this method decreased by stabilizing vertebral pain occurred in the first 12 hours after vertebroplasty (cf. value 4.8±1,2 hours, from 30 minutes to 12 hours), the average pain intensity decreased to 4.5 ±0,6 (from 2 to 6). After the treatment of bone metastases with samarium-153 oksa bifor, pain intensity decreased by 3,9 ± 0,3 days (range from 2 to 6) and reached the level of 0,9 ± 0,5 (from 0 to 2). Value pain scores before and after treatment was significantly different, and was P <0,0001.
Thus, the combination of vertebroplasty, radionuclide therapy with samarium-153 oksabifor and systemic therapy with bisphosphonates (Zolendronic acid) in patients with gastric cancer with bone metastases can be treated in the presence or threat of vertebral fractures, which gives an opportunity to expand the indications for palliative radionuclide therapy and improve efficiency treatment of severe category of patients with multiple bone metastases and pain. The proposed approach allows us to quickly achieve durable and pronounced reduction in pain intensity, significantly reduce the need for analgesics.
About the Authors
N. V. Rasulova
Acad. V. Vakhidov’s Republican Specialized Center of Surgery
Uzbekistan
Uzbekistan
Department of radioisotope diagnostic laboratory, Tashkent
D. T. Arybzhanov
South Kazakhstan Regional Oncology Center
Kazakhstan
Kazakhstan
Department of chemotherapy and endovascular oncology, Shymkent
F. Z. Dzhalalov
National Research Centre for Emergency Medicine
Uzbekistan
Department of Interventional Radiology, Tashkent
Uzbekistan
Department of Interventional Radiology, Tashkent
Kyeong Hwan Kim
Hospital Hyundai
Korea, Democratic People's Republic of
Korea, Democratic People's Republic of
Department of Orthopaedics, Namyangzhu
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Review
For citations:
Rasulova N.V., Arybzhanov D.T., Dzhalalov F.Z., Kim K.H. THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON. Creative surgery and oncology. 2013;(3):52-57. (In Russ.) https://doi.org/10.24060/2076-3093-2013-0-3-52-57
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