Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)
https://doi.org/10.24060/2076-3093-2019-9-4-293-296
Abstract
This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their role in the progression of the pathological process or resolution of a disease. The data presented in some research works confirms the relationship between the presence of tumour-specific (tumour-associated) tertiary lymphoid structures and a favourable prognosis in patients with various oncological diseases, which suggests the participation of tertiary lymphoid structures in effective local antitumour immune responses. However, no reliable evidence has so far been obtained that could confirm the contribution of tertiary lymphoid structures to immune processes in vivo, with the available information being largely of a correlative character.
It should be emphasized that the clinical significance of tertiary lymphoid structures ranges from a destructive to protective impact, which indicates the need for an improved understanding of the structure and case-specific function of these organs before conducting clinical targeting.
It should be emphasized that the clinical significance of tertiary lymphoid structures ranges from a destructive to protective impact, which indicates the need for an improved understanding of the structure and case-specific function of these organs before conducting clinical targeting.
Keywords
tertiary lymphoid structures,
cancer,
prognosis,
CD3,
CD20,
T-lymphocytes,
B-lymphocytes,
dendritic cells
About the Authors
R. A. Rustamkhanov
Bashkir State Medical University
Russian Federation
Russian Federation
Rustamkhanov Rasul Aydarovich — Assistant lecturer of the Department of Oncology with Oncology and Anatomical Pathology courses in the Institute of Additional Professional Education
3 Lenin str., Ufa, 450008
K. Sh. Gantsev
Bashkir State Medical University;
Republican Clinical Oncology Center
Russian Federation
Russian Federation
Gantsev Kamil Shamilevich — Doctor of Medical Sciences, Professor of the Department of Oncology, Oncologist at the Department of Urology No. 7
3 Lenin str., Ufa, 450008;
73/1 Oktyabrya ave., Ufa, 450054
D. S. Tursumetov
Bashkir State Medical University, 3 Lenin str., Ufa, 450008
Russian Federation
Tursumetov Davlat Saytmuratovich — Candidate of Medical Sciences, Associate Professor of the Department of Oncology with Oncology and Anatomical Pathology courses in the Institute of Additional Professional Education
Russian Federation
Tursumetov Davlat Saytmuratovich — Candidate of Medical Sciences, Associate Professor of the Department of Oncology with Oncology and Anatomical Pathology courses in the Institute of Additional Professional Education
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Review
For citations:
Rustamkhanov R.A., Gantsev K.Sh., Tursumetov D.S. Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review). Creative surgery and oncology. 2019;9(4):293-296. (In Russ.) https://doi.org/10.24060/2076-3093-2019-9-4-293-296
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