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Clinical and Pathological Analysis of Sudden Death after Planned Surgery

https://doi.org/10.24060/2076-3093-2020-10-2-154-161

Abstract

Introduction. The growth of oncological morbidity and the advent of novel surgery methods to improve quality of life and longevity entail a steady growth of noncardiac surgery in elderly patients. Provided the general aging of the population, an increase in the number of comorbid patients and a growing use of medical implanted devices, the assessment of main risk factors for perioperative complications acquires a higher relevance.

Materials and methods. On the basis of a clinical case of an elderly patient, approaches to perioperative risk assessment; methods for risk factor isolation during the preoperative stage; and the importance of informing the patient about the incurred risk are discussed.

Results and discussion. A postmortem examination established stage IV coronary atherosclerosis of 3rd degree, stenosis of left and right coronary artery lumen to 60–80%, atherosclerotic plaque wall raptures in the left coronary artery with haemorrhage into the base (“unstable plaque”), ischemic myocardial dystrophy, pockets of abnormal myocardial blood flow. Th e conducted analysis of the clinical case, along with a review of existing literature sources and American and European guidelines for cardiac risk assessment in non-surgical patients, demonstrates the need for updating domestic recommendations on perioperative risk assessment. Such a revision should complement the current international experience with the meta-analysis of the prognostic value of stress tests, routine coronary angiography and preventive pre-surgical coronary recanalisation.

Conclusion. It can be concluded that the existing clinical recommendations and risk assessment scales fail to provide immediate solutions to ensure sufficient patient’s safety in the operating room; rather, these documents should only be considered as a vector for decision making in particular clinical circumstances.

About the Authors

A. V. Samorodov
Bashkir State Medical University
Russian Federation

Aleksandr V. Samorodov — Dr. Sci. (Med.), Department of Anesthesiology and Intensive Care with a course of Advanced Professional Education.



A. L. Urakov
Izhevsk State Medical Academy
Russian Federation

Aleksandr L. Urakov — Dr. Sci. (Med.), Prof., Department of General and Clinical Pharmacology.



K. N. Zolotukhin
G.G. Kuvatov Republican Clinical Hospital
Russian Federation

Konstantin N. Zolotukhin — Cand. Sci. (Med.), Department of Anaesthesiology and Critical Care No. 1.



R. R. Dashkin
G.G. Kuvatov Republican Clinical Hospital
Russian Federation

Ravil R. Dashkin — Republican Morbid Anatomy Bureau.



N. G. Ismagilov
G.G. Kuvatov Republican Clinical Hospital
Russian Federation

Nail G. Ismagilov — Republican Morbid Anatomy Bureau.



A. I. Abubakirova
G.G. Kuvatov Republican Clinical Hospital
Russian Federation

Alfi ya I. Abubakirova — Department of Clinical Pharmacology.



Z. R. Pakhomova
G.G. Kuvatov Republican Clinical Hospital
Russian Federation

Zulfi ya R. Pakhomova — Clinical and Diagnostic Laboratory.



Z. R. Mukhametshina
G.G. Kuvatov Republican Clinical Hospital
Russian Federation

Zulfi ya R. Mukhametshina — Clinical and Diagnostic Laboratory.



References

1. Campbell D., Boyle L., Soakell-Ho M., Hider P., Wilson L., Koea J., et al. National risk prediction model for perioperative mortality in non-cardiac surgery. Br J Surg. 2019;106(11):1549–57. DOI: 10.1002/bjs.11232

2. Ackland G.L., Abbott T.E.F., Cain D., Edwards M.R., Sultan P., Karmali S.N., et al. Preoperative systemic infl ammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery. Br J Anaesth. 2019;122(2):180–7. DOI: 10.1016/j.bja.2018.09.002

3. McNeely C., Markwell S., Filson K., Hazelrigg S., Vassileva C. Eff ect of hospital volume on prosthesis use and mortality in aortic valve operations in the elderly. Ann Th orac Surg. 2016;101(2):585–90. DOI: 10.1016/j.athoracsur.2015.07.010

4. Daniel V.T., Rushing A.P., Ingraham A.M., Ricci K.B., Paredes A.Z., Diaz A., et al. Association between operating room access and mortality for life-threatening general surgery emergencies. J Trauma Acute Care Surg. 2019;87(1):35–42. DOI: 10.1097/TA.0000000000002267

5. Lin H.S., Watts J.N., Peel N.M., Hubbard R.E. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016;16(1):157. DOI: 10.1186/s12877-016-0329-8

6. Sprung J., Warner M.E., Contreras M.G., Schroeder D.R., Beighley C.M., Wilson G.A. Predictors of survival following cardiac arrest in patients undergoing noncardiac surgery: a study of 518 294 patients at a tertiary referral center. Anesthesiology. 2003;99(2):259–69. DOI: 10.1097/00000542-200308000-00006

7. Al-Oweidi A.S., Albabtain H., Kharabsheh S.M., Kimme P., Almustafa M., Seder S., et al. Prevalence and predictors of myocardial ischemia by preoperative myocardial perfusion single photon emission computed tomography in patients undergoing noncardiac surgery. Ann Saudi Med. 2017;37(6):461–8. DOI: 10.5144/0256-4947.2017.461

8. McEvoy J.W., Chen Y., Rawlings A., Hoogeveen R.C., Ballantyne C.M., Blumenthal R.S., et al. Diastolic blood pressure, subclinical myocardial damage, and cardiac events: implications for blood pressure control. J Am Coll Cardiol. 2016;68(16):1713–22. DOI: 10.1016/j.jacc.2016.07.754

9. Zhang L.J., Li N., Li Y., Zeng X.T., Liu M.Y. Cardiac biomarkers predicting MACE in patients undergoing noncardiac surgery: a meta-analysis. Front Physiol. 2019;9:1923. DOI: 10.3389/fphys.2018.01923

10. Lee T.H., Marcantonio E.R., Mangione C.M., Th omas E.J., Polanczyk C.A., Cook E.F., et al. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation 1999;100:1043–9. DOI: 10.1161/01.cir.100.10.1043

11. Smith T., Li X., Nylander W., Gunnar W. Th irty-day postoperative mortality risk estimates and 1-year survival in veterans health administration surgery patients. JAMA Surg. 2016;151(5):417–22. DOI: 10.1001/jamasurg.2015.4882

12. Smilowitz N.R., Gupta N., Ramakrishna H., Guo Y., Berger J.S., Bangalore S. Perioperative major adverse cardiovascular and cerebrovascular events associated with noncardiac surgery. JAMA Cardiol. 2017;2(2):181–7. DOI: 10.1001/jamacardio.2016.4792

13. Khubchandani J.A., Ingraham A.M., Daniel V.T., Ayturk D., Kiefe C.I., Santry H.P. Geographic diff usion and implementation of acute care surgery: an uneven solution to the National Emergency General Surgery Crisis. JAMA Surg. 2018;153(2):150–9. DOI: 10.1001/jamasurg.2017.3799

14. Palasubramaniam J., Wang X., Peter K. Myocardial infarction-from atherosclerosis to thrombosis. Arterioscler Th romb Vasc Biol. 2019;39(8):e176–85. DOI: 10.1161/ATVBAHA.119.312578

15. Magoon R., Makhija N., Das D. Perioperative myocardial injury and infarction following non-cardiac surgery: A review of the eclipsed epidemic. Saudi J Anaesth. 2020;14(1):91–9. DOI: 10.4103/sja.SJA_499_19

16. Helwani M.A., Amin A., Lavigne P., Rao S., Oesterreich S., Samaha E., et al. Etiology of Acute Coronary Syndrome aft er Noncardiac Surgery. Anesthesiology. 2018;128(6):1084–91. DOI: 10.1097/ALN.0000000000002107

17. Vester-Andersen M., Lundstrom L.H., Buck D.L., Moller M.H. Association between surgical delay and survival in high-risk emergency abdominal surgery. A population-based Danish cohort study. Scand J Gastroenterol. 2016;51(1):121–8. DOI: 10.3109/00365521.2015.1066422

18. Vrsalović M., Vrsalović Presečki A. Admission C-reactive protein and outcomes in acute aortic dissection: a systematic review. Croat Med J. 2019;60(4):309–15. DOI: 10.3325/cmj.2019.60.309

19. Buse G.L., Manns B., Lamy A., Guyatt G., Polanczyk C.A., Chan M.T.V., et al. Troponin T monitoring to detect myocardial injury aft er noncardiac surgery: a cost-consequence analysis. Can J Surg. 2018;61(3):185–94. DOI: 10.1503/cjs.010217

20. Habbab K.M., D’Aiuto F., Habbab M.A., Porter S.R. Molecular markers relevant to myocardial injury following dental extraction in patients with or without coronary artery disease. BDJ Open. 2019;5:9. DOI: 10.1038/s41405-019-0018-8

21. Michailidou M., Kulvatunyou N., Friese R.S., Gries L., Green D.J., Joseph B., et al. Time and cost analysis of gallbladder surgery under the acute care surgery model. J Trauma Acute Care Surg. 2014;76(3):710–4. DOI: 10.1097/TA.0000000000000117

22. Juan Wang, Guo-Juan Tan, Li-Na Han, Yong-Yi Bai, Miao He, Hong-Bin Liu. Novel biomarkers for cardiovascular risk prediction. J Geriatr Cardiol. 2017;14(2):135–50. DOI: 10.11909/j.issn.1671-5411.2017.02.008

23. Hansson G.K., Libby P., Tabas I. Inflammation and plaque vulnerability. J Intern Med. 2015;278(5):483–93. DOI: 10.1111/joim.12406

24. Rahat T., Nguyen T., Latif F. Role of prophylactic coronary revascularisation in improving cardiovascular outcomes during non-cardiac surgery: A narrative review. Neth Heart J. 2016;24(10):563–70. DOI: 10.1007/s12471-016-0871-1

25. Bilimoria K.Y., Liu Y., Paruch J.L., Zhou L., Kmiecik T.E., Ko C.Y., et al. Development and evaluation of the universal ACS NSQIP surgical risk calculator: a decision aid and informed consent tool for patients and surgeons. J Am Coll Surg. 2013;217:833–42. DOI: 10.1016/j.jamcollsurg.2013.07.385

26. Kertai M.D., Boersma E., Bax J.J., Heijenbrok-Kal M.H., Hunink M.G., L’Talien G.J., et al. A meta-analysis comparing the prognostic accuracy of six diagnostic tests for predicting perioperative cardiac risk in patients undergoing major vascular surgery. Heart. 2003;89:1327–34. DOI: 10.1136/heart.89.11.1327


Review

For citations:


Samorodov A.V., Urakov A.L., Zolotukhin K.N., Dashkin R.R., Ismagilov N.G., Abubakirova A.I., Pakhomova Z.R., Mukhametshina Z.R. Clinical and Pathological Analysis of Sudden Death after Planned Surgery. Creative surgery and oncology. 2020;10(2):154-161. (In Russ.) https://doi.org/10.24060/2076-3093-2020-10-2-154-161

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ISSN 2076-3093 (Print)
ISSN 2307-0501 (Online)