INHIBITION OF CANCER CELL INVASION AND METASTASIS BY NF-KAPPA-B INHIBITORS (ИНГИБИРОВАНИЕ ИНВАЗИИ РАКОВЫХ КЛЕТОК И МЕТАСТАЗОВ ПРИ ПОМОЩИ ИНГИБИТОРОВ NF-КАППА-B)
https://doi.org/10.24060/2076-3093-2013-0-3-6-12
Abstract
We designed a potent and specific NF-kappa-B inhibitor called dehydroxymethylepoxyquinomicin (DHMEQ), based on the structure of epoxyquinomicins, which are weak antibiotics isolated from Amicolatopsis. It is believed that inhibition of NFkappa -B may play a significant role in controlling the process of metastasis. We have therefore synthesized derivatives of about 20, of which DTCMglutarimide (DTCM-G). We have evaluated the antimetastatic activity of the preparation using murine melanoma B16-F10. It was found that DTCM-G inhibits cell invasion and induces anoikoz in cells B16-F10. This preparation is non-toxic and easy to manufacture. Thus , it can be considered as a new candidate for the antimetastatic drug.
About the Authors
T. Ukaji
Keio University
Japan
Japan
Sh. Kh. Gаntsev
Scientific Research Institute of Oncology, Bashkir State Medical University, Ufa
Russian Federation
Russian Federation
K. Umezawa
Aichi Medical University, School of Medicine
Japan
Japan
Department of Molecular Target Medicine Screening, Nagakute
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Review
For citations:
Ukaji T., Gаntsev Sh.Kh., Umezawa K. INHIBITION OF CANCER CELL INVASION AND METASTASIS BY NF-KAPPA-B INHIBITORS (ИНГИБИРОВАНИЕ ИНВАЗИИ РАКОВЫХ КЛЕТОК И МЕТАСТАЗОВ ПРИ ПОМОЩИ ИНГИБИТОРОВ NF-КАППА-B). Creative surgery and oncology. 2013;(3):6-12. https://doi.org/10.24060/2076-3093-2013-0-3-6-12
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