КЛИНИЧЕСКИЕ ОСОБЕННОСТИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ С ЭКСПРЕССИЕЙ РЕЦЕПТОРОВ СТЕРОИДНЫХ ПОЛОВЫХ ГОРМОНОВ И АМПЛИФИКАЦИЕЙ HER2
https://doi.org/10.24060/2076-3093-2013-0-3-84-92
Аннотация
С середины прошлого века рак молочной железы принято считать высоко гетерогенной группой опухолей. Гетерогенность основана на различном клиническом течении заболевания, а также на принципиально различной чувствительности к существующим терапевтическим подходам. В основе клинических решений о выборе тактики лечения на настоящий момент лежит сочетание клинических и патоморфологических прогностических и предиктивных маркеров. Наибольшую роль среди морфологических предиктивных маркеров играют рецепторы эстрогенов, прогестерона и эпидермального фактора роста HER2-neu. При этом клиническая группа, характеризующаяся проявлением всех трех маркеров, характеризуется относительно неблагоприятным прогнозом и невысокой чувствительностью к существующим лекарственным методам. Авторам представляется интересным суммировать имеющиеся данные о клинических особенностях данного типа опухолей молочной железы.
Об авторах
Ф. В. МоисеенкоРоссия
Моисеенко Федор Владимирович - старший научный сотрудник лаборатории нанобиотехнологий СПб АУ НОЦНТ РАН.
194021, Санкт-Петербург, ул. Хлопина, д. 8, корпус 3, e-mail: Moiseenkofv@gmail.com
В. Ф. Семиглазов
Россия
Семиглазов Владимир Федорович - руководитель отдела опухолей молочной железы ФГБУ НИИ онкологии имени Н.Н. Петрова Минздрава России
Т. Ю. Семиглазова
Россия
Семиглазова Татьяна Юрьевна - старший научный сотрудник отдела терапевтической онкологии ФГБУ НИИ онкологии имени Н.Н. Петрова Минздрава России
А. А. Богданов
Россия
Богданов Алексей Александрович - старший научный сотрудник лаборатории нанобиотехнолдогий, СПб АУ НОЦНТ РАН.
194021, Санкт-Петербург, ул. Хлопина, д.8, корпус 3
И. Е. Елисеев
Россия
Елисеев Игорь Евгеньевич - младший научный сотрудник лаборатории нанобиотехнологий СПб АУ НОЦНТ РАН
А. О. Иванцов
Россия
Иванцов Александр Олегович - врач отделения патоморфологии ФГБУ НИИ онкологии имени Н.Н. Петрова Минздрава России
Н. А. Князев
Россия
Князев Николай Александрович - младший научный сотрудник лаборатории нанобиотехнологий СПб АУ НОЦНТ РАН
И. Н. Тертеров
Россия
Тертеров Иван Николаевич - младший научный сотрудник лаборатории нанобиотехнологий СПб АУ НОЦНТ РАН
А. А. Корнев
Россия
Корнев Антон Анатольевич - младший научный сотрудник лаборатории нанобиотехнологий СПб АУ НОЦНТ РАН
М. В. Дубина
Россия
Дубина Михаил Владимирович - руководитель лаборатории нанобиотехнологий СПб АУ НОЦНТ РАН
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Рецензия
Для цитирования:
Моисеенко Ф.В., Семиглазов В.Ф., Семиглазова Т.Ю., Богданов А.А., Елисеев И.Е., Иванцов А.О., Князев Н.А., Тертеров И.Н., Корнев А.А., Дубина М.В. КЛИНИЧЕСКИЕ ОСОБЕННОСТИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ С ЭКСПРЕССИЕЙ РЕЦЕПТОРОВ СТЕРОИДНЫХ ПОЛОВЫХ ГОРМОНОВ И АМПЛИФИКАЦИЕЙ HER2. Креативная хирургия и онкология. 2013;(3):84-92. https://doi.org/10.24060/2076-3093-2013-0-3-84-92
For citation:
Moiseenko F.V., Semiglazov V.F., Semiglazova T.Yu., Bogdanov A.A., Eliseev I.E., Ivantsov A.O., Knyasev N.А., Terterov I.N., Kornev А.A., Dubina M.V. CLINICAL CHARACTERISTICS OF BREAST CANCER WITH STEROID RECEPTORS EXPRESSION AND HER2 AMPLIFICATION. Creative surgery and oncology. 2013;(3):84-92. (In Russ.) https://doi.org/10.24060/2076-3093-2013-0-3-84-92