NEOLYMPHOGENESIS AND CHEMOKINES’EXPRESSION PROFILE DURING BREAST CANCER

The research of surgical material including a primary breast tumor, lymphatic basins with lymph nodes revealed the fact of neo-lymphatic genesis of breast cancer patients. Evidentiary basis  of the genetic  lymphoid  re-forming  is  made   with  the use  of modern biological technologies. Inflammatory chemokines’ expression profile and  their receptors in newly formed lymph nodes  during breast cancer  were analyzed. The analysis revealed an increase in CCL16, XCR1, CYFIP2, TNFSF14 genes  and  a decrease in CXCL5 and  CXCL12 chemokines’ ligands in newly formed lymph nodes .The data got are of a great scientific importance.

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