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Modern Techniques for Cervical Cancer Radiotherapy

https://doi.org/10.24060/2076-3093-2021-11-1-58-67

Abstract

Cervical cancer is a socially significant illness often impacting women of reproductive and working age. The patients’ young age and social activity warrant the development of effective and safe therapies.

The past decades have witnessed the novel radiation techniques to contain cervical cancer: 3DCRT-3D, IMRT, and VMAT, adaptive radiotherapy, CT/MRI-guided intracavitary radiation, combined interstitial and intracavitary radiation, abandoning intracavitary intervention for external beam delivery with sequential or concurrent cervical dose escalation, under brachytherapy unfeasible.

Modern equipment and treatment planning systems allow a high dose delivery to the tumour and intracavitary treatment with visual control of the target and organs at risk. Combining of intracavitary and interstitial radiotherapy enables a better dose coverage of the target at a minimal radiation impact on organs at risk.

Phasing-out of intracavitary for external radiotherapy may enable a cancericide dose delivery to the tumour under intractable intracavitary treatment.

The major goal of technic novelties is the establishment of personalised radiotherapy for improving treatment outcomes and reducing the incidence and/or severity of radiation side effects. The article overviews the radiotherapy techniques for cervical cancer treatment and routes of their development.

About the Authors

P. A. Lushnikova
Tomsk Regional Oncology Dispensary
Russian Federation

Polina A. Lushnikova — Department of Radiotherapy

Tomsk



E. S. Sukhikh
Tomsk Regional Oncology Dispensary; Tomsk National Research Polytechnic University
Russian Federation

Evgeniya S. Sukhikh — Cand. Sci. (Phys.-Math.), Department of Medical Physics, Department of Radiotherapy, Department of Nuclear Fuel Cycle

Tomsk



P. V. Izhevsky
Russian State Research Center — Burnazyan Federal Medical Biophysical Centre; Moscow Pedagogical State University
Russian Federation

Pavel V. Izhevskiy — Cand. Sci. (Med.), Chair of Medicine and Operating Security

Moscow



Ya. N. Sutygina
Tomsk Regional Oncology Dispensary; Tomsk National Research Polytechnic University
Russian Federation

Yana N. Sutygina — Department of Radiotherapy

Tomsk



M. A. Tatarchenko
Tomsk Regional Oncology Dispensary; Tomsk National Research Polytechnic University
Russian Federation

Maria A. Tatarchenko — Department of Radiotherapy

Tomsk



I. B. Pyzhova
Tomsk Regional Oncology Dispensary
Russian Federation

Irina B. Pyzhova — Department of Radiotherapy

Tomsk



References

1. Kravets O.A., Kuznetsov V.V., Morkhov K.Yu., Nechushkina V.M., Khokhlova S.V. Cervical cancer: clinical practice guideline. Moscow; 2018 (In Russ.).

2. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021, Feb 4. DOI: 10.3322/caac.21660

3. Briko N.I., Lopukhov P.D., Kaprin A.D., Novikova E.G., Trushina O.I., Khaldin Kh., et al. HPV-associated lesions in the Russian Federation: assessment of the problem. Journal of Modern Oncology. 2019;21(1):45–50 (In Russ.). DOI: 10.26442/18151434.2019.190199

4. Arkhangelskaya P.A., Bakhidze E.V., Berlev I.V., Samsonov R.B., Ivanov M.K., Malek A.V. MicroRNA, HPV and cervical carcinogenesis: molecular aspects and prospects of clinical application. Siberian journal of oncology. 2016;15(4):88–97 (In Russ.). DOI:10.21294/1814-4861-2016-15-4-88-97

5. Kravets O.A., Romanova E.A., Gorbunova V.A. Clinical results of radiation and chemoradiation therapy of locally advanced cervix cancer. Russian Journal of Oncology. 2020;25(3):92–102 (In Russ.). DOI: 10.17816/1028-9984-2020-25-3-92-102

6. Hansen E.K., Roach M. (eds). Handbook of evidence-based radiation oncology. Springer; 2018.

7. Khokhlova S.V., Kolomiets L.A., Kravets O.A., Morkhov K.Yu., Nechushkina V.M., Novikova E.G., et al. RUSSCO practical guidelines. Drug treatment for cervical cancer. Malignant tumours. 2018;8(3S2):156–70 (In Russ.).

8. Reyes Santiago D.K., Khadzhimba A.S., Smirnova M.P., Maksimov S.Ya. The role of surgical stage in combination therapy for patients with locally advanced cervical cancer. Problems in Oncology. 2019;65(5):749–55 (In Russ.). DOI: 10.37469/0507-3758-2019-65-5-749-755

9. Chino J., Annunziata C.M., Beriwal S., Bradfield L., Erickson B.A., Fields E.C., et al. Radiation therapy for cervical cancer: executive summary of an ASTRO Clinical Practice Guideline. Pract Radiat Oncol. 2020;10(4):220–34. DOI: 10.1016/j.prro.2020.04.002

10. Wainson A.A., Mescherikova V.V., Tkachev S.I. Radio-thermomodifying effect of platinum-based drugs, gemzar and taxane on tumor cells in vitro. Russian Journal of biotherapy. 2017;16(S):17–8 (In Russ.).

11. Tharavichitkul E., Lorvidhaya V., Kamnerdsupaphon P., Sukthomya V., Chakrabandhu S., Klunklin P., et al. Combined chemoradiation of cisplatin versus carboplatin in cervical carcinoma: a single institution experience from Thailand. BMC Cancer. 2016;16:501. DOI: 10.1186/s12885-016-2558-9

12. Nwachukwu C.R., Mayadev J., Viswanathan A.N. Concurrent chemoradiotherapy for stage IIIB cervical cancer — Global impact through power. JAMA Oncol. 2018;4(4):514–5. DOI: 10.1001/jamaoncol.2017.5078

13. Giavedoni M.E., Staringer L., Garrido R., Bertoncini C., Sardi M., Perrotta M. Experience with concurrent chemoradiotherapy treatment in advanced cervical cancer: results from a hospital in Argentina. Ecancermedicalscience. 2019;13:919. DOI: 10.3332/ecancer.2019.919

14. Kaprin A.D., Novikova E.G., Rerberg A.G., Chulkova O.V., Maltsagova Kh.R. Regional chemotherapy: a current approach in the treatment of locally advanced cervical cancer. Oncogynecology. 2019;3:51–60 (In Russ.).

15. Suvorova Yu.V., Tarazov P.G., Zharinov G.M., Agafonova M.V. Method for treating malignant uterine tumots. Russian Federation patent RU 2185858. 2002 Jule 27 (in Russ.).

16. Ashrafjan L.A., Aleshikova O.I., Antonova I.B., Babaeva N.A., SHakhbazjan K.R., Vashakmadze S.L., Gerfanova E.V. Method of treating cervical cancer using chemoembolisation of uterine arteries with platinum drugs. Russian Federation patent RU 2583144. 2015 Apr 28 (In Russ.).

17. Lux F., Tran V.L., Thomas E., Dufort S., Rossetti F., Martini M., et al. AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine. Br J Radiol. 2019;92(1093):20180365. DOI: 10.1259/bjr.20180365

18. Pötter R., Haie-Meder Ch., Van Limbergen E., Barillot I., De Brabandere M., Dimopoulos J., et al. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy—3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol. 2006;78(1):67–77. DOI: 10.1016/j.radonc.2005.11.014

19. Kravets O.A., Kozlov O.V., Fedyanina A.A., Kuznetsov M.A., Nechushkin M.I. Cervix cancer 3D brachytherapy methodic aspects. Meditsinskaya Fizika. 2017;1:16–24 (In Russ.).

20. Banerjee R., Kamrava M. Brachytherapy in the treatment of cervical cancer: a review. Int J Womens Health. 2014;6:555–64. DOI: 10.2147/IJWH.S46247

21. Naga Ch.P., Gurram L., Chopra S., Mahantshetty U. The management of locally advanced cervical cancer. Curr Opin Oncol. 2018;30(5):323–9. DOI: 10.1097/CCO.0000000000000471

22. Kashihara T., Kobayashi K., Iijima K., Murakami N., Yoshida K., Okuma K., et al. A case report of a patient with bulky uterine cervical neoplasm who achieved complete response with “intentional internal high-dose policy” high-dose-rate interstitial brachytherapy. Medicine (Baltimore). 2020;99(27):e20860. DOI: 10.1097/MD.0000000000020860

23. Prescribing, recording, and reporting brachytherapy for cancer of the cervix. J ICRU. 2013;13(1–2):NP. DOI: 10.1093/jicru/ndw027

24. Mahmoud O., Kilic S., Khan A.J., Beriwal S., Small W. Jr. External beam techniques to boost cervical cancer when brachytherapy is not an option-theories and applications. Ann Transl Med. 2017;5(10):207. DOI: 10.21037/atm.2017.03.102

25. Campitelli M., Lazzari R., Piccolo F., Ferrazza P., Marsella A.R., Macchia G., et al. Brachytherapy or external beam radiotherapy as a boost in locally advanced cervical cancer: a Gynaecology Study Group in the Italian Association of Radiation and Clinical Oncology (AIRO) review. Int J Gynecol Cancer. 2021:ijgc-2020-002310. DOI: 10.1136/ijgc-2020-002310

26. Sukhikh E., Sukhikh L. Dosimetric and radiobiological evaluation of combined radiotherapy of cervical cancer based on the VMAT technique. In: Gynaecological Malignancies. IntechOpen; 2019. DOI: 10.5772/intechopen.89734

27. Shwetha B., Ravikumar M., Palled S.R., Supe S.S., Sathiyan S. Dosimetric comparison of high dose rate brachytherapy and intensity-modulated radiation therapy for cervical carcinoma. J Med Phys. 2011;36(2):111–6. DOI: 10.4103/0971-6203.79687

28. Guo M., Huang E., Liu X., Tang Y. Volumetric modulated arc therapy versus fixed-field intensity-modulated radiotherapy in radical irradiation for cervical cancer without lymphadenectasis: dosimetric and clinical results. Oncol Res Treat. 2018;41(3):105–9. DOI: 10.1159/000484608

29. Pedicini P., Caivano R., Fiorentino A., Strigari L., Califano G., Barbieri V., et al. Comparative dosimetric and radiobiological assessment among a nonstandard RapidArc, standard RapidArc, classical intensity-modulated radiotherapy, and 3D brachytherapy for the treatment of the vaginal vault in patients affected by gynecologic cancer. Med Dosim. 2012;37(4):347–52. DOI: 10.1016/j.meddos.2011.11.009

30. Cilla S., Macchia G., Digesù C., Deodato F., Sabatino D., Morganti A.G., et al. Endocavitary in vivo dosimetry for IMRT treatments of gynecologic tumors. Med Dosim. 2011;36(4):455–62. DOI: 10.1016/j.meddos.2010.12.002

31. Guerrero M., Li X.A., Ma L., Linder J., Deyoung C., Erickson B. Simultaneous integrated intensity-modulated radiotherapy boost for locally advanced gynecological cancer: radiobiological and dosimetric considerations. Int J Radiat Oncol Biol Phys. 2005;62(3):933–9. DOI: 10.1016/j.ijrobp.2004.11.040

32. Vergalasova I., Light K., Chino J., Craciunescu O. Simultaneous integrated boost (SIB) for treatment of gynecologic carcinoma: Intensity-modulated radiation therapy (IMRT) vs volumetric-modulated arc therapy (VMAT) radiotherapy. Med Dosim. 2017;42(3):230–7. DOI: 10.1016/j.meddos.2017.05.002

33. Sukhikh Е.S., Sukhikh L.G., Anikeeva О.Yu., Izhevsky P.V., Sheino I.N. Dosimetric evaluation for various methods of combined radiotherapy of cervical cancer. Medical Radiology and Radiation Safety. 2019;64(1):45–52 (In Russ.). DOI: 10.12737/article_5c55fb4a074ee1.27347494

34. Herrera F.G., Callaway S., Delikgoz-Soykut E., Coskun M., Porta L., Meuwly J.Y., et al. Retrospective feasibility study of simultaneous integrated boost in cervical cancer using Tomotherapy: the impact of organ motion and tumor regression. Radiat Oncol. 2013;8:5. DOI: 10.1186/1748-717X-8-5

35. Gee M.S., Atri M., Bandos A.I., Mannel R.S., Gold M.A., Lee S.I. Identification of distant metastatic disease in uterine cervical and endometrial cancers with FDG PET/CT: analysis from the ACRIN 6671/GOG 0233 Multicenter Trial. Radiology. 2018;287(1):176–84. DOI: 10.1148/radiol.2017170963

36. Feng C.H., Hasan Y., Kopec M., Al-Hallaq H.A. Simultaneously integrated boost (SIB) spares OAR and reduces treatment time in locally advanced cervical cancer. J Appl Clin Med Phys. 2016;17(5):76–89. DOI: 10.1120/jacmp.v17i5.6123

37. Sukhikh E.S., Vertinsky A.V., Sinyagina M.A., Modebadze G.S., Sheffres E.V., Sukhikh L.G. Dosimetric assessment of the combined course of radiation therapy for cervical cancer with different treatment planning systems. Meditsinskaya Fizika. 2018;3:18–23 (In Russ.).

38. Sukhikh E.S., Sukhikh L.G., Lushnikova P.A., Tatarchenko M.A., Abdelrahman A.R. Dosimetric and radiobiological comparison of simultaneous integrated boost and sequential boost of locally advanced cervical cancer. Physica Medica. 2020;73:83–8. DOI: 10.1016/j.ejmp.2020.04.012

39. Mazzola R., Ricchetti F., Fiorentino A., Levra N.G., Fersino S., Di Paola G., et al. Weekly cisplatin and volumetric-modulated arc therapy with simultaneous integrated boost for radical treatment of advanced cervical cancer in elderly patients: feasibility and clinical preliminary results. Technol Cancer Res Treat. 2017;16(3):310–5. DOI: 10.1177/1533034616655055


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For citations:


Lushnikova P.A., Sukhikh E.S., Izhevsky P.V., Sutygina Ya.N., Tatarchenko M.A., Pyzhova I.B. Modern Techniques for Cervical Cancer Radiotherapy. Creative surgery and oncology. 2021;11(1):58-67. (In Russ.) https://doi.org/10.24060/2076-3093-2021-11-1-58-67

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ISSN 2076-3093 (Print)
ISSN 2307-0501 (Online)