Stromal Vascular Fraction: Biology and Application Outlook
V. N. Pavlov,
A. A. Kazikhinurov,
R. A. Kazikhinurov,
M. A. Agaverdiev,
I. F. Gareev,
O. A. Beylerli,
B. Z. Mazorov https://doi.org/10.24060/2076-3093-2021-11-1-92-99
Abstract
Stromal vascular fraction (SVF) is a heterogeneous cell extract obtained with enzymatic dissociation of adipose tissue followed by centrifugation. This population includes many different cell types, i.a. adipose tissue stem cells (ATSCs), vascular endothelial and smooth muscle cells and their precursors, pericytes, fibroblasts, macrophages, T-lymphocytes, etc., excluding mature adipocytes. The main SVF component is ATSCs capable of self-renewal and multipotent differentiation. Since early research on SVF, an extensive effort has been aimed at understanding its clinical applications promoting a significant progress in the SVF use for treatment of various diseases and injuries. The past decade has witnessed an upward publication trend in basic and clinical research into the SVF therapeutic value. Manifold methods and devices for the SVF isolation from human liposuction lipoaspirate have been developed, continuously contributing to preclinical and clinical trials of its safety and efficacy. This review discusses the main properties and functions of the SVF cell population, its efficacy and safety for human therapy.
About the Authors
V. N. Pavlov
Bashkir State Medical University
Russian Federation
Russian Federation
Valentin N. Pavlov — Dr. Sci. (Med.), Prof., RAS Corresponding Member, Department of Urology with a course of Advanced Professional Education
Ufa
A. A. Kazikhinurov
Bashkir State Medical University
Russian Federation
Russian Federation
Albert A. Kazikhinurov — Dr. Sci. (Med.), Prof., Department of Urology with a course of Advanced Professional Education
Ufa
R. A. Kazikhinurov
Bashkir State Medical University
Russian Federation
Russian Federation
Rustem A. Kazikhinurov — Cand. Sci. (Med.), Assoc. Prof., Department of Urology with a course of Advanced Professional Education
Ufa
M. A. Agaverdiev
Bashkir State Medical University
Russian Federation
Russian Federation
Murad A. Agaverdiev — Department of Urology with a course of Advanced Professional Education
Ufa
I. F. Gareev
Bashkir State Medical University
Russian Federation
Russian Federation
Ilgiz F. Gareev — Cand. Sci. (Med.), Central Research Laboratory
Ufa
O. A. Beylerli
Bashkir State Medical University
Russian Federation
Russian Federation
Ozal A. Beylerli — Central Research Laboratory
Ufa
B. Z. Mazorov
Bashkir State Medical University
Russian Federation
Russian Federation
Bakhodur Z. Mazorov — Department of Urology with a Course of Advanced Professional Education
Ufa
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Review
For citations:
Pavlov V.N., Kazikhinurov A.A., Kazikhinurov R.A., Agaverdiev M.A., Gareev I.F., Beylerli O.A., Mazorov B.Z. Stromal Vascular Fraction: Biology and Application Outlook. Creative surgery and oncology. 2021;11(1):92-99. (In Russ.) https://doi.org/10.24060/2076-3093-2021-11-1-92-99
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