Bowen's Disease: Literature Review
Z. R. Khismatullina,
E. V. Lipova,
A. A. Khammatova,
M. I. Khabibullina,
E. Najafizade,
K. Z. Ianbarisova https://doi.org/10.24060/2076-3093-2023-13-1-68-76
Abstract
The paper presents the results of the bibliographic research materials on Bowen's disease over the past 15 years. The aetiopathogenesis of the disease is not yet fully understood; however, most experts designate the following trigger factors: prolonged use of drugs that suppress the immune response, human papillomavirus, light skin type, and excessive exposure to sunlight, ionizing radiation, arsenic intake. Clinical manifestations of Bowen's disease take anular, verrucous, pigmented, and acral forms. Atypical variants of the disease include “giant” Bowen's disease, and cases of localization of lesions on the face. The paper describes the clinical symptoms of each clinical form of Bowen's disease, diagnostic methods, and various treatment methods used in foreign and domestic practice. Comparative results of research on the treatment methods of Bowen's disease include such methods as surgical removal, Mohs micrographic surgery, photodynamic therapy, curettage, cryotherapy, laser ablation, radiation therapy as well as conservative treatment methods. The latter include topical application of external remedies (fluorouracil, imiquimod, diclofenac), as they can be quite effective in certain cases. The advantages of photodynamic therapy are indicated both in terms of high efficiency and in the safety spectrum of treatment of Bowen's disease.
About the Authors
Z. R. Khismatullina
Bashkir State Medical University
Russian Federation
Russian Federation
Zarema R. Khismatullina — Dr. Sci. (Med.), Prof., Department of Dermatovenerology with Courses of Dermatovenerology and Cosmetology for Advanced Professional Education
Ufa
E. V. Lipova
A.I. Burnasyan Federal Medical Biophysical Center FMBA
Russian Federation
Russian Federation
Elena V. Lipova — Dr. Sci. (Med.), Prof., Department of Dermatovenerology and Cosmetology with a Course of Clinical Laboratory Diagnostics
Moscow
A. A. Khammatova
Republican Dermatovenereal Dispensary
Russian Federation
Russian Federation
Alsu A. Khammatova — Dermatology Unit No. 1
Ufa
M. I. Khabibullina
Bashkir State Medical University
Russian Federation
Russian Federation
Milyausha I. Khabibullina — Department of Dermatovenerology with Courses of Dermatovenerology and Cosmetology for Advanced Professional Education
Ufa
E. Najafizade
Bashkir State Medical University
Russian Federation
Russian Federation
Elakhe Najafizade — Department of Dermatovenerology with Courses of Dermatovenerology and Cosmetology for Advanced Professional Education
Ufa
K. Z. Ianbarisova
Bashkir State Medical University
Russian Federation
Russian Federation
Kamilla Z. Ianbarisova — 6th year Student
Ufa
References
1. Molina-García M., Malvehy J., Granger C., Garre A., Trullàs C., Puig S. Exposome and skin. Part 2. The influential role of the exposome, beyond UVR, in actinic keratosis, Bowen's disease and squamous cell carcinoma: a proposal. Dermatol Ther (Heidelb). 2022;12(2):361–80. DOI: 10.1007/s13555-021-00644-3
2. Azimi A., Yang P., Ali M., Howard V., Mann G.J., Kaufman K.L., et al. Data independent acquisition proteomic analysis can discriminate between actinic keratosis, Bowen's disease, and cutaneous squamous cell carcinoma. J Invest Dermatol. 2020;140(1):212–22.e11. DOI: 10.1016/j.jid.2019.06.128
3. de Jong E., Lammerts M.U.P.A., Genders R.E., Bouwes Bavinck J.N. Update of advanced cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol. 2022;36 Suppl 1(Suppl 1):6–10. DOI: 10.1111/jdv.17728
4. Hama N., Ohtsuka T., Yamazaki S. Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen’s disease and squamous cell carcinoma of the skin. J Dermatol 2006;33:331–7. DOI: 10.1111/j.1346-8138.2006.00078.x
5. Jiang K.W., Zhao C.Y., Chan C., Peduto M.Y., Kailainathan G., Cook D.K. Eruptive Bowen's disease in a patient on pembrolizumab for Hodgkin's lymphoma. Australas J Dermatol. 2021;62(3):e435–7. DOI: 10.1111/ajd.13652
6. Drake A.L., Walling H.W. Variations in presentation of squamous cell carcinoma in situ (Bowen’s disease) in immunocompromised patients. J Am Acad Dermatol. 2008;59:68–71. DOI: 10.1016/j.jaad.2008.03.028
7. Hampton S., Timmis J. Actinic keratosis and Bowen's disease: case of a Leg Club member. Br J Community Nurs. 2020;25(Sup12):S39–40. DOI: 10.12968/bjcn.2020.25.Sup12.S39
8. Chung J.Y., Yu S.D., Hong Y.S. Environmental source of arsenic exposure. J Prev Med Public Health. 2014;47(5):253–7. DOI: 10.3961/jpmph.14.036
9. Yu H.S., Liao W.T., Chai C.Y. Arsenic carcinogenesis in the skin. J Biomed Sci. 2006;13(5):657–66. DOI: 10.1007/s11373-006-9092-8
10. Morton C.A., Birnie A.J., Eedy D.J. British Association of Dermatologists' guidelines for the management of squamous cell carcinoma in situ (Bowen's disease) 2014. Br J Dermatol. 2014;170:245–60. DOI:10.1111/bjd.12766
11. Lacarrubba F., Verzì A.E., Caltabiano R., Micali G. Bowen's disease of the penile shaft presenting as a pigmented macule: dermoscopy, reflectance confocal microscopy and histopathological correlation. An Bras Dermatol. 2021;96(5):609–12. DOI: 10.1016/j.abd.2020.10.009
12. Jansen P., Baguer D.O., Duschner N., Le'Clerc Arrastia J., Schmidt M., Wiepjes B., et al. Evaluation of a deep learning approach to differentiate Bowen's disease and seborrheic keratosis. Cancers (Basel). 2022;14(14):3518. DOI: 10.3390/cancers14143518
13. Palaniappan V., Karthikeyan K. Bowen's Disease. Indian Dermatol Online J. 2022;13(2):177–89. DOI: 10.4103/idoj.idoj_257_21
14. Liang D.G., Soliman B., Cha J. A rare case of Bowen's disease of the nipple: Literature review and management pathway. Breast J. 2020;26(6):1234–8. DOI: 10.1111/tbj.13824
15. Chan S.L., Watchorn R.E., Panagou E., Panou E., Ong E.L., Heelan K., et al. Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat. Australas J Dermatol. 2019;60(3):e201–7. DOI: 10.1111/ajd.12981
16. Mishra J., Pandia A., Padhy A.K., Mahapatra M., Mohapatra J., Nayak B., et al. Bowen's disease of vulva: A rare case of vulvar premalignant disorder. Clin Cancer Investig J. 2020;9(5):210. DOI: 10.4103/ccij.ccij_61_20
17. Nagakeerthana S., Rajesh G., Madhavi S., Karthikeyan K. Bowen's disease: Two case reports of a giant and dwarf lesions. J Can Res Ther. 2017;13(2):371–3. DOI: 10.4103/0973-1482.187237
18. Ianosi S.L., Batani A., Ilie M.A., Tampa M., Georgescu S.R., Zurac S., et al. Non-invasive imaging techniques for the in vivo diagnosis of Bowen's disease: Three case reports. Oncol Lett. 2019;17(5):4094–101. DOI: 10.3892/ol.2019.10079
19. Morton C.A., Whitehurst C., McColl J.H., Moore J.V., MacKie R.M. Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma. Arch Dermatol. 2001;137(3):319–24. PMID: 11255332
20. Lopez N., Meyer-Gonzalez T., Herrera-Acosta E., Bosch R., Castillo R., Herrera E. Photodynamic therapy in the treatment of extensive Bowen's disease. J Dermatolog Treat. 2012;23(6):428–30. DOI: 10.3109/09546634.2011.590789
21. Mazilli S., Gamo-Villegas R., Pampin-Franco A., Lopez Estebaran J.L., Pinedo F., Vollono L., et al. Reflectance confocal microscopy of pigmented Bowen's disease: A Case series of difficult to diagnose lesions. Case Rep Dermatol. 2020;12(2):98–106. DOI: 10.1159/000507916
22. Neagu T.P., Ţigliş M., Botezatu D., Enache V., Cobilinschi C.O., Vâlcea-Precup M.S., et al. Clinical, histological and therapeutic features of Bowen’s disease. Rom J Morphol Embryol. 2017;58(1):33–40. PMID: 28523295
23. Yang Y., Lin J., Fang S., Han S., Song Z. What’s new indermoscopy of Bowen’s disease: Two new dermoscopic signs and its differential diagnosis. Int J Dermatol. 2017;56(10):1022–5. DOI: 10.1111/ijd.13734
24. Wozniak-Rito A.M., Rudnicka L. Bowen's disease in dermoscopy. Acta Dermatovenerol Croat. 2018;26(2):157–61. PMID: 29989873
25. Narahira A., Yanagi T., Kitamura S., Hata H., Shimizu H. Dermoscopic features of genital pigmented Bowen's disease: Report of a case and review of the published work. J Dermatol. 2019;46(10):e390–1. DOI: 10.1111/1346-8138.14938
26. Leibovitch I., Huilgol S.C., Selva D., Richards S., Paver R. Cutaneous squamous carcinoma in situ (Bowen's disease): treatment with Mohs micrographic surgery. J Am Acad Dermatol. 2005;52(6):997–1002. DOI: 10.1016/j.jaad.2004.12.033
27. Luo Z., Chen M., Su J., Chen X., Zhao S. A case of bowenoid papulosis treated with sequential curettage and photodynamic therapy. Photodermatol Photoimmunol Photomed. 2020;36(3):251–3. DOI: 10.1111/phpp.12540
28. Sharma A., Birnie A.J., Bordea C., Cheung S.T., Mann J., Morton C.A., et al. British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma in situ (Bowen disease) 2022. Br J Dermatol. 2023;00:1–9. DOI: 10.1093/ bjd/ljac042
29. Hansen J.P., Drake A.L., Walling H.W. Bowen’s disease: a four-year retrospective review of epidemiology and treatment at a university center. Dermatol Surg. 2008; 34(7):878–83. DOI: 10.1111/j.15244725.2008.34172.x
30. Ahmed I., Berth-Jones J., Charles-Holmes S., O'Callaghan C.J., Ilchyshyn A. Comparison of cryotherapy with curettage in the treatment of Bowen's disease: a prospective study. Br J Dermatol. 2000;143(4):759–66. DOI: 10.1046/j.1365-2133.2000.03772.x
31. Morton C.A., Whitehurst C., Moseley H., McColl J.H., Moore J.V., Mackie R.M. Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease. Br J Dermatol. 1996;135(5):766–71. PMID: 8977678
32. Genouw E., Verheire B., Ongenae K., De Schepper S., Creytens D., Verhaeghe E., et al. Laser-assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's disease: a randomized intrapatient comparison between a continuous and a fractional ablative CO2 laser mode. J Eur Acad Dermatol Venereol. 2018;32(11):1897–905. DOI: 10.1111/jdv.14989
33. Tantikun N. Treatment of Bowen's disease of the digit with carbon dioxide laser. J Am Acad Dermatol. 2000;43(6):1080–3. DOI: 10.1067/ mjd.2000.109841
34. Covadonga Martínez-González M., del Pozo J., Paradela S., Fernández-Jorge B., Fernández-Torres R., Fonseca E. Bowen's disease treated by carbon dioxide laser. A series of 44 patients. J Dermatolog Treat. 2008;19(5):293–9. DOI: 10.1080/09546630701870772
35. Fader D.J., Lowe L. Concomitant use of a high-energy pulsed CO2 laser and a long-pulsed (810 nm) diode laser for squamous cell carcinoma in situ. Dermatol Surg. 2019;28(1):97–9. DOI: 10.1046/j.15244725.2002.01091.x
36. Zygogianni A., Kouvaris J., Tolia M., Kyrgias G., Beli I., Kantzou I., et al. The potential role of radiation therapy in Bowen's disease: a review of the current literature. Rev Recent Clin Trials. 2012;7(1):42–6. DOI: 10.2174/157488712799363271
37. McKenna D.J., Morris S., Kurwa H. Treatment-resistant giant unilateral Bowen’s disease of the scalp responding to radiotherapy. Clin Exp Dermatol. 2016;34(1):85–6. DOI: 10.1111/j.1365-2230.2008.02757.x
38. Herman J.M., Pierce L.J., Sandler H.M., Griffith K.A., Jabbari S., Hiniker S.M., et al. Radiotherapy using a water bath in the treatment of Bowen's disease of the digit. Radiother Oncol. 2008;88(3):398–402. DOI: 10.1016/j.radonc.2008.05.025
39. Cox N.H. Bowen’s disease: where now with therapeutic trials? Br J Dermatol. 2000;143:699–700. DOI: 10.1046/j.13652133.2000.03819.x
40. Park H.E, Park J.W., Kim Y.H, Han J.H., Bang C.H., Park Y.M., et al. Analysis on the effectiveness and characteristics of treatment modalities for Bowen's Disease: an observational study. J Clin Med. 2022;11(10):2741. DOI: 10.3390/jcm11102741
41. Mo Y.W., Lee D.L. Comparison of the recurrence rate of 3 treatment modalities for Bowen disease in an aging city: A retrospective multivariate analysis. Medicine (Baltimore). 2020;99(27):e19893. DOI: 10.1097/MD.0000000000019893
42. Jansen M.H., Appelen D., Nelemans P.J., Winnepenninckx V.J., Kelleners-Smeets N.W.J., Mosterd K. Bowen's disease: long-term results of treatment with 5-fluorouracil cream, photodynamic therapy or surgical excision. Acta Derm Venereol. 2018;98(1):114–5. DOI: 10.2340/00015555-2777
43. Zhong S., Zhang R., Mei X., Wang L. Efficacy of photodynamic therapy for the treatment of Bowen's disease: An updated systematic review and meta-analysis of randomized controlled trials. Photodiagnosis Photodyn Ther. 2020;32:102037. DOI: 10.1016/j.pdpdt.2020.102037
44. Gaitanis G., Bassukas I.D. Immunocryosurgery — an effective combinational modality for Bowen's disease. Dermatol Ther. 2016;29(5):334– 7. DOI: 10.1111/dth.12371
45. Morton C., Horn M., Leman J., Tack B., Bedane C., Tjioe M., et al. Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: Results of a multicenter randomized trial. Arch Dermatol. 2006;142(6):729–35. DOI: 10.1001/archderm.142.6.729
46. Mohanna M.T., Hofbauer G.F. Bowenoid actinic keratosis and Bowen's disease treated successfully with ingenol mebutate. Dermatology. 2016;232 Suppl 1:14–6. DOI: 10.1159/000447390
47. Gomez C., Cobos M., Alberdi E. Methyl aminolevulinate-based photodynamic therapy of Bowen´s disease: Observational study of 21 lesions. Photodiagnosis Photodyn Ther. 2019;26:295–9. DOI: 10.1016/j.pdpdt.2019.04.011
48. Morton C.A., Szeimies R.M., Basset-Seguin N., Calzavara-Pinton P., Gilaberte Y., Haedersdal M., et al. European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications — actinic keratoses, Bowen's disease and basal cell carcinomas. J Eur Acad Dermatol Venereol. 2019;33(12):2225–38. DOI: 10.1111/jdv.16017
49. Aguilar-Bernier M., Rodríguez-Barón D., Rivas-Ruiz F., Segura-Palacios J.M., de Troya Martín M. Long-term efficacy of photodynamic therapy with methyl aminolevulinate in treating Bowen’s disease in clinical practice: A retrospective cohort study (2006–2017). Photodermatol Photoimmunol Photomed. 2019;35(4):208–13. DOI: 10.1111/phpp.12453
50. O'Connell K.A., Okhovat J.P., Zeitouni N.C. Photodynamic therapy for Bowen's Disease (squamous cell carcinoma in situ) current review and update. Photodiagnosis Photodyn Ther. 2018;24:109–14. DOI: 10.1016/j.pdpdt.2018.09.009
51. Xue W.L., Ruan J.Q., Liu H.Y., He H.X. Efficacy of photodynamic therapy for the treatment of Bowen's disease: a meta-analysis of randomized controlled trials. Dermatology. 2022;238(3):542–50. DOI: 10.1159/000519319
52. Robustelli Test E., Fumo G., Corbeddu M., Ferreli C., Rongioletti F. Efficacy of Imiquimod 3.75 % for the treatment of extensive Bowen's disease of the face in an elderly patient. Dermatol Ther. 2020;33(2):e13263. DOI: 10.1111/dth.13263
53. Provini A., Ruggeri S., Mazzanti C., Pilla M.A., Ricci F., Panebianco A., et al. Successful treatment of two cases of perianal Bowen disease with photodynamic therapy followed by imiquimod cream. Dermatol Ther. 2020;33(4):e13759. DOI: 10.1111/dth.13759
54. Lo T.K., Chen Y.C., Liu W.T., Wong T.W. Successful treatment of giant Bowen's disease with photodynamic therapy and subsequent imiquimod in a case with chronic arsenic exposure. Photodiagnosis Photodyn Ther. 2022;40:103128. DOI: 10.1016/j.pdpdt.2022.103128
Review
For citations:
Khismatullina Z.R., Lipova E.V., Khammatova A.A., Khabibullina M.I., Najafizade E., Ianbarisova K.Z. Bowen's Disease: Literature Review. Creative surgery and oncology. 2023;13(1):68-76. (In Russ.) https://doi.org/10.24060/2076-3093-2023-13-1-68-76
Views:
2157
Email this article 