ORIGINAL ARTICLES
The article presents the results of the study depending survival of patients with breast cancer (BC) stage IIIb degree from neolymphangiogenesis . The results show that the higher the degree neolymphangiogenesis on the level lymphangion at the drainage area “sentinel“ lymph node, the more pronounced local compensatory and protective reactions of the organism affecting the duration of life in breast cancer.
This article presents an overview and results of treatment of malignant neoplasms of the liver hepatic artery chemoembolization methods in 141 patients. The analysis of the results of this method of treatment.
In this article results of the multicenter trial are displayed. Data of successful efficacy of trastuzumab treatment in HER2 positive gastric cancer patients has shown.
The results of examination and treatment of 105 patients with glandular hyperplasia of the endometrium, have done. The age of women ranged from 24 to 55 years, the average was equal to 42.3 +3.1 years ; reproductive age was 61 patients, 44 menopausal period. The diagnosis of glandular endometrial hyperplasia (ZHE) is set on the basis of ultrasound TVUZI, hysteroscopy, morphological study scraping the uterine mucosa. All patients carried hormone therapy for 6 months: estrogenprogestin, antiestrogen , progestin, progestogens. Efficacy in patients of reproductive age was observed in 43 (70.5 %) patients, in patients with perimenopausal in 30 ( 68.2 %) coses.
In 34,8% patients relapse glandular hyperplasia of the endometrium (for the period from 1 to 3 years). Transcervical electrosurgical resection ( ablation) of the endometrium were performed. The results showed the effectiveness of endometrial ablation surgery in 90.6% of patients. Thus, in the absence of therapeutic effect of hormone therapy, recurrent uterine bleeding and endometrial hyperplasia, glandular, has hysteroscopic resection surgery (ablation) of the endometrium the high efficacy.
The interrelation of polymorphic loci genes cytokine profile with indicators spontaneous cytokine production oxists. Combination of genotypes identified family interleukin -1, and having functional significance adaptive " mutant " alleles (* E2/* II /* C) in the genes of the interleukin -1 was significantly more frequent in cancer patients " risk" alleles of the tumor suppressor gene TP53. It’s revealed that the cancer patients in the combined genotype " mutant " alleles in the gene not only NQO1, but also genes of the interleukin -1 wich where studied.
This article is devoted to the analysis and synthesis of classification and terminology issues of colorectal cancer. There is no standards about this pathology nowadays in the world. This fact prevents analysis of the morbidity and outcomes of treatment patients with colorectal cancer. It is necessary to compose a classification which can determine the generalization of the cancer and adequate surgical treatment.
The article analyzed the incidence of gastric cancer in the Republic of Bashkortostan from 1993 to 2002 and from 2003 to 2012. A comparative analysis of cancer incidence rates of primary tumors of the stomach, obtained regularities level dynamics of disease in different years, depending on age and gender.
EXPERIENCE OF HEALTHCARE FACILITIES
Different versions of ectopic thyroid gland are rare in routine clinical practice and are associated with a defect of thyroid embryogenesis in its early stages. Symptoms depend on the location and size of ectopic thyroid function and its morphological structure. Diagnosis is based on ray methods of investigation. Choice of treatment: hormone suppression, radiofrequency ablation, surgery.
Criteria of efficiency of conservative therapy of chronic tonsillitis are increase of viable lymphocytes and reduction of the apoptotic of lymphocytes. The optimum ratio of quantity of live lymphocytes to quantity of lymphocytes being able apoptosis for a period of up to 6-7 months allows to keep the complex treatment of chronic tonsillitis including washing of lacunas of palatal almonds by solute of miramistin, contact ultrasonic processing of palatal almonds, preparation application.
In connection with the expansion of indications for osteosynthesis with the use of metal, the surgical treatment of closed fractures of the bones, increases the frequency of postoperative osteomyelitis. We analyzed the results of treatment of 102 patients with postoperative osteomyelitis treated at City Clinical Hospital number 18 in 2008-2011.
We investigated laboratory parameters (levels of procalcitonin, C-reactive protein and leukocyte index of intoxication) in 25 patients undergoing osteosynthesis using metal structures in closed fractures of tubular bones.
After osteosynthesis using metal structures in closed fractures of tubular bones in 3,2% of cases developed postoperative osteomyelitis. The changes in laboratory parameters in 16 (64%) patients, in other cases results were within normal limits. Study of the levels of procalcitonin, C-reactive protein and leukocyte index of intoxication do not have significant practical value for predicting postoperative osteomyelitis.
The material is presented in article about the principles of treatment of a chronic pain syndrome at oncological patients on the example of experience of office of the palliative help of the Republican clinical Oncology Dispensary of Ufa. The office structure, methods and schemes of treatment of pain at patients with generalized forms of a cancer are in detail stated.
This article is devoted to studying the long-term results of multiorgan procedures in treatment of colorectal cancer. We reviewed our experience with 25 patients who underwent surgical treatment about locally advanced colorectal cancer considering previously developed theory of tumor penetration. The reliability of this theory was confirmed. In comparison of two groups of patients with local and locally advanced colorectal cancer the results are similar.
The results of clinical and experimental studies of the effectiveness of radiotherapy in combination with cisplatin and Ftorafur in the comparative analysis with radiation therapy, radiation therapy in kombintsii with fluorouracil and cisplatin. Preliminary studies indicate that radiation therapy in combination with cisplatin and ftorafur affect longer diseasefree period. The question of chemoradiation therapy for cervical cancer remains open, and the results of the study indicate the need for further studies using chemoradiation radiomodifying derivatives fluoropyrimidines series.
A comparative study of the greater omentum 60 healthy women and 40 patients with ovarian cancer has done. Found that when the disease omentum reduced in size, density decreases and size of lymphoid elements. This morphological pattern indicates a decrease in the immune properties of the greater omentum.
LITERATURE REVIEW
The article analyzes the results of a randomized multicenter studies devoted to elucidate the role of adjuvant and neoadjuvant chemotherapy, targeted therapy, adjuvant chemoradiation therapy in improving the results of surgical treatment of gastric cancer.
The article presents data on the growth and development of breast tissue. A detailed morphogenesis mammary gland, occurring in mammary epithelium during the life of the woman with the changes of the stroma was presented.
On the basis of world literature data described anatomic features of structure of human breast, demonstrated the processes occurring in the breast tissue in breast cancer, described some of the molecular mechanisms of interaction between cancer cells and adipocytes.
The article presents an overview of the literature on the study of the mechanisms of formation of intratumoral and peritumoral lymphatic vessels in cancer and their role in regional and distant metastasis. Lymphangiogenesis complex multifactorial process, the study of which helps to clarify the overall flow pattern of the tumor process.
Article is devoted to one of ancient sections of medicine treatment of wounds. However treatment is long not healing wounds and now remains to one of important problems of medicine. Terms of healing of ulcers at the majority of patients make 2–3 months, at a number of patients they don’t begin to live for years, and the frequency of recurrence at conservative treatment reaches 60–70%. Big prevalence of trophic ulcers and insufficient efficiency of existing conservative methods of treatment lead to the huge economic damage caused by disability.
An overview of literature devoted to the problem of induction, transplantation and artificial creation of new lymph nodes has done. Results of research of domestic and foreign scholars in the field were presented.
During the last three decades, the understanding of the biology and pathways of dissemination of tumors with intraperitoneal spread, and the understanding of the protective function of the peritoneal barrier against tumoral seeding, has prompted the concept that PC is a loco-regional disease: in absence of other systemic metastases, multimodal approaches combining aggressive cytoreductive surgery, intraperitoneal hyperthermic chemotherapy and systemic chemotherapy have been proposed and are actually considered promising methods to improve loco-regional control of the disease, and ultimately to increase survival. The aim of this review article is to present the evidence on treatment of PC in different tumors, in order to provide patients with a proper surgical and multidisciplinary treatment focused on optimal control of their locoregional disease.
ISSN 2307-0501 (Online)