Preview

Creative surgery and oncology

Advanced search
No 4 (2013)
View or download the full issue PDF (Russian)
https://doi.org/10.24060/2076-3093-2013-0-4

ORIGINAL ARTICLES

4-8 595
Abstract

The article presents the results of the study depending survival of patients with breast cancer (BC) stage IIIb degree from neolymphangiogenesis . The results show that the higher the degree neolymphangiogenesis on the level lymphangion at the drainage area “sentinel“ lymph  node, the  more  pronounced local compensatory and  protective reactions of  the organism affecting the duration of life in breast cancer.

8-16 722
Abstract

This article presents an overview and results  of treatment of malignant neoplasms of the  liver hepatic artery  chemoembolization methods in 141 patients. The analysis  of  the results of this method of treatment.

16-22 708
Abstract

In this article results of the multicenter trial are displayed. Data of successful efficacy of trastuzumab treatment in HER2 positive gastric cancer patients has shown.

23-27 47223
Abstract

The results of examination and treatment of 105 patients with glandular hyperplasia of the endometrium, have done.  The age of women ranged from  24 to 55 years, the average was equal to 42.3 +3.1 years ; reproductive age was 61 patients, 44 menopausal period. The diagnosis of glandular endometrial hyperplasia (ZHE) is set on the basis of ultrasound TVUZI, hysteroscopy, morphological study scraping the uterine mucosa. All patients carried hormone therapy for 6 months: estrogenprogestin, antiestrogen , progestin, progestogens. Efficacy in patients of reproductive age was observed in 43 (70.5  %)  patients, in patients with perimenopausal in 30 ( 68.2 %) coses.

In 34,8% patients relapse  glandular hyperplasia of the  endometrium (for  the  period from  1 to 3 years).  Transcervical electrosurgical resection ( ablation) of the  endometrium were  performed. The results  showed the  effectiveness of  endometrial ablation surgery in 90.6% of  patients. Thus,  in the  absence of  therapeutic effect of  hormone therapy, recurrent  uterine  bleeding   and   endometrial  hyperplasia, glandular,  has  hysteroscopic resection surgery (ablation) of the endometrium the high efficacy.

28-35 614
Abstract

The interrelation of polymorphic loci genes  cytokine profile with indicators spontaneous cytokine  production oxists.  Combination of  genotypes identified family interleukin  -1, and having functional significance adaptive " mutant " alleles (* E2/* II /* C) in the genes of the interleukin -1 was significantly  more frequent in cancer patients " risk" alleles of the tumor  suppressor gene TP53. It’s revealed that  the cancer patients in the combined genotype " mutant " alleles in the gene not only NQO1, but also genes of the interleukin -1 wich where studied.

36-43 786
Abstract

This article is devoted to the  analysis and  synthesis  of classification and  terminology issues  of  colorectal  cancer.  There is no standards about this pathology nowadays in the world.  This fact  prevents analysis  of  the  morbidity  and  outcomes of  treatment patients with colorectal  cancer.  It is necessary to compose a classification which can determine the generalization of the cancer and adequate surgical treatment.

44-53 632
Abstract

The article analyzed  the  incidence  of gastric  cancer  in the  Republic of Bashkortostan from  1993 to  2002  and  from  2003  to  2012. A comparative analysis  of  cancer  incidence rates  of primary tumors of the stomach, obtained regularities level dynamics  of disease  in different years, depending on age and gender.

EXPERIENCE OF HEALTHCARE FACILITIES

54-58 1498
Abstract

Different versions of ectopic  thyroid  gland  are rare in routine  clinical practice  and are associated with a defect of thyroid embryogenesis in its early stages. Symptoms  depend on the location and size of ectopic thyroid function and its morphological structure. Diagnosis is based  on  ray  methods of  investigation. Choice  of  treatment:  hormone suppression, radiofrequency ablation, surgery.

59-61 753
Abstract

Criteria of efficiency of conservative therapy of chronic tonsillitis are increase of viable lymphocytes and reduction of the apoptotic of lymphocytes. The optimum ratio of quantity of live lymphocytes to quantity of lymphocytes being able apoptosis for a period of up to 6-7 months allows to keep the complex treatment of chronic tonsillitis including washing  of lacunas of palatal almonds by solute of miramistin, contact ultrasonic  processing of palatal almonds, preparation application. 

62-64 1988
Abstract

In connection with  the  expansion of  indications for  osteosynthesis with  the  use  of metal,  the  surgical  treatment of  closed  fractures of  the  bones, increases  the  frequency of postoperative osteomyelitis. We analyzed  the results of treatment of 102 patients with postoperative osteomyelitis treated at City Clinical Hospital number 18 in 2008-2011.

We  investigated laboratory parameters  (levels  of  procalcitonin, C-reactive  protein and leukocyte  index of intoxication) in 25 patients undergoing osteosynthesis using metal structures in closed fractures of tubular bones. 

After osteosynthesis using metal structures in closed fractures of tubular bones in 3,2% of  cases  developed  postoperative  osteomyelitis.  The  changes  in  laboratory  parameters  in 16 (64%) patients, in other  cases  results  were  within normal  limits. Study of the  levels of procalcitonin, C-reactive protein and leukocyte index of intoxication do not have significant practical value for predicting postoperative osteomyelitis.

65-69 1020
Abstract

The material  is presented in article about the principles of treatment of a chronic pain syndrome at oncological  patients on the  example  of experience of office of the  palliative help of the Republican clinical Oncology  Dispensary of Ufa. The office structure, methods and  schemes of  treatment of  pain at patients with  generalized forms  of  a cancer  are  in detail stated.

70-76 464
Abstract

This article is devoted to studying the  long-term results  of  multiorgan procedures in treatment of colorectal cancer. We reviewed our experience with 25 patients who underwent surgical   treatment  about  locally  advanced  colorectal   cancer   considering   previously developed theory  of  tumor  penetration. The reliability of  this  theory  was  confirmed. In comparison of two groups  of patients with local and locally advanced colorectal  cancer the results are similar.

76-80 686
Abstract

The results of clinical and experimental studies  of the effectiveness of radiotherapy in combination with cisplatin and Ftorafur in the comparative analysis with radiation therapy, radiation therapy in kombintsii  with fluorouracil  and cisplatin.  Preliminary studies  indicate that  radiation therapy in combination with  cisplatin  and  ftorafur affect longer  diseasefree  period.  The question of  chemoradiation therapy for  cervical cancer  remains  open, and  the  results  of  the  study  indicate  the  need  for  further studies  using  chemoradiation radiomodifying derivatives fluoropyrimidines series.

80-83 1561
Abstract

A comparative study of the greater omentum 60 healthy  women and 40 patients with ovarian  cancer  has done.  Found that  when  the  disease  omentum reduced in size, density decreases and size of lymphoid  elements. This morphological pattern indicates  a decrease in the immune  properties of the greater omentum.

LITERATURE REVIEW

84-91 797
Abstract

The  article  analyzes   the   results   of  a  randomized  multicenter  studies   devoted to elucidate the role of adjuvant and neoadjuvant chemotherapy, targeted therapy, adjuvant chemoradiation therapy in improving the results of surgical treatment of gastric cancer.

91-95 531
Abstract

The article presents data  on the  growth and development of breast tissue.  A detailed morphogenesis mammary gland,  occurring  in mammary epithelium  during  the  life of the woman with the changes of the stroma was presented.

95-99 675
Abstract

On the basis of world literature data described anatomic features of structure of human breast, demonstrated the processes occurring in the breast tissue in breast cancer, described some of the molecular mechanisms of interaction between cancer cells and adipocytes.

100-108 521
Abstract

The article presents an overview of the  literature on the  study  of the  mechanisms of formation of  intratumoral and  peritumoral lymphatic  vessels  in cancer  and  their  role in regional  and  distant metastasis.  Lymphangiogenesis complex  multifactorial process, the study of which helps to clarify the overall flow pattern of the tumor  process.

108-112 930
Abstract

Article is devoted to one of ancient sections of medicine treatment of wounds. However treatment is long not  healing  wounds and  now remains  to one of important problems of medicine.  Terms of  healing  of  ulcers at  the  majority  of  patients make  2–3  months, at  a number of patients they don’t begin to live for years,  and the  frequency of recurrence at conservative treatment reaches 60–70%. Big prevalence of trophic  ulcers and insufficient efficiency of  existing  conservative methods  of  treatment lead  to  the  huge  economic damage caused  by disability.

112-115 488
Abstract

An overview  of  literature devoted to  the  problem  of  induction, transplantation and artificial  creation of  new  lymph  nodes  has  done.  Results  of  research of  domestic and foreign scholars in the field were presented.

115-119 1938
Abstract

During  the  last  three  decades, the  understanding of  the  biology  and  pathways of dissemination  of  tumors  with  intraperitoneal spread,  and   the   understanding  of  the protective function  of  the   peritoneal barrier   against  tumoral seeding, has  prompted the  concept that  PC is a loco-regional disease:  in absence of  other  systemic  metastases, multimodal approaches combining  aggressive cytoreductive surgery,  intraperitoneal hyperthermic chemotherapy and  systemic  chemotherapy have  been  proposed and  are actually considered promising methods to improve loco-regional control of the disease, and ultimately  to increase  survival. The aim of this review article is to present the  evidence  on treatment of PC in different tumors, in order to provide patients with a proper  surgical and multidisciplinary treatment focused on optimal control of their locoregional  disease.



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2076-3093 (Print)
ISSN 2307-0501 (Online)