We designed a potent and specific NF-kappa-B inhibitor called dehydroxymethylepoxyquinomicin (DHMEQ), based  on the  structure of epoxyquinomicins, which are weak  antibiotics isolated from Amicolatopsis. It is believed that  inhibition of NFkappa  -B may play a significant role in controlling the process of metastasis. We have therefore synthesized derivatives of about 20, of which DTCMglutarimide (DTCM-G). We have evaluated the antimetastatic activity of the preparation using murine melanoma B16-F10. It was found that  DTCM-G inhibits cell invasion and induces anoikoz in cells B16-F10. This preparation is non-toxic and easy to manufacture. Thus , it can be considered as a new candidate for the antimetastatic drug.

Sjogren’s syndrome (SS) is a non-hereditary and relatively common disease  with adult onset. It is characterized by extreme tiredness, diminished  exocrine  glandular function, specific auto-antibody production and focal infiltration of B and T lymphocytes. The disease may be also complicated by malignant lymphoma. Most SS patients have high serum levels of anti-nuclear antibodies (ANA), and the ANA subtypes SS-A and SS-B (autoantibodies to RNA-modifying spliceosome components) are used as diagnostic markers of SS. Antibodies to chromatin make  cancer  cells more  sensitive  to DNA-binding  cytostatic drugs  suggests that  indeed  the  ANA in SS may  have  some  influence on  cellular functions, and  perhaps contribute to SS patients’ symptoms.

A most recent  report from our department has demonstrated that  ANA including SS-A and SS-B are present at high titres in sera obtained from SS patients many years before the onset  of symptoms, and even longer times before the diagnosis was established.

Breast cancer  continues as a major health  problem  among women.  Globally, it is the most common cancer of women and represents the second leading cause of death.  Breast cancer continues however, to be one of those  cancers that  prove the greatest benefit when detected early.

The diagnosis of breast cancer can often generate fear and anxiety for the woman and the people  she know and loves and as a result may predispose the woman to psychosocial reactions, resulting  in poorer  health  outcomes. As a consequence, clinicians can no longer focus specifically on the physical aspects related to the treatment of breast cancer, but must also recognize and  consider  the  psychosocial implications  of  the  diagnosis and  enhance their treatment to gain better outcomes.

Implementing a psychosocial model of care and incorporating aspects of the patient’s care  to  include  family  concerns, financial  implications  of  illness and  employment issues related to prolonged treatment can and should be considered as part of treatment.

There is no better time than  today  to enhance our skills for the  better treatment and care of our mothers, wives, sisters, aunts, nieces, daughters and granddaughters who may someday face a diagnosis of breast cancer.

Results of treatment of 60 patients with gastric  cancer  with liver metastases are analyzed. Immediate results have shown  the effectiveness of treatment after 2 cycles of TACE in 49(81,7%) patients: partial response was observed in 36 (60%) patients and a significant regression of the process  was observed in 13 (21,6%) patients, the process  of stabilization was observed in 11 (18,3%) patients. Subsequent evaluation of the effectiveness of the results of treatment of patients after 4 and 6 courses of TACE were identical. Partial response was observed in the  process  of 18 (30%) patients, stabilization persisted in 12 (20%) patients.  The progression by 8-9  months of  treatment was  seen  in 30  (50%) patients. In assessing the  general  condition of patients focused on the  quality of life for patients. All patients  had  a  positive  treatment  outcome  overall  by  Karnovsky  remained  at  the  level  of 75-80% (ECOG 1-2), which does not limit the patients and did not require prolonged hospitalization. The average time of hospitalization of patients with each course  (cycle) TACE averaged 5±2  day. In the dynamic tracking  of patients in terms  of 12, 18, 24 months more than 12 months 24 (40%) patients are alive, 11 (18,3%) patients are alive during 18 months.  8 (13,3%) patients are alive during 24 months. Median survival was 15,5±1,2 months.

Thus, in the present the TACE method in stomach cancer metastasis treatment can be considered like an effective, low toxicity method of  treatment and  may be a method of choice for improving survival and quality of life of the difficult category of patients.

This  article  analyzes   the   possibility  of   practical   application  of   the   most-studied molecular  biological markers  in the diagnosis and treatment of cancer.  The possibilities of the  use of genetic  markers  for  the  diagnosis of hereditary preventive  caused  tumors, for the early detection of cancer, targeted therapy for the selection, monitoring and prognosis of the  disease. We proposed the  universal algorithm for the  study  of molecular  biological markers. The feasibility of the introduction of molecular biological research in laboratory of Clinical Oncology Dispensary of the Republic of Bashkortostan has examined. 

The role of the level of prostate specific antigen ( PSA) before initial therapy discusses widely as a prognostic factor in the  treatment of prostate cancer  (PC ). Despite  the  fact that  many of the questions on the diagnostic and prognostic value of PSA unclear, and new markers  of prostate diseases  are being introduced with increasing  frequency , we assume that  the PSA will continue to be one of the main methods of screening and monitoring of patients with prostate cancer, because of its high diagnostic value due to tissue specificity. Using the  initial PSA level and  Gleason  score  improves  the  predictive  value significantly. This article presents the  results  of a retrospective analysis of 307 patients completed the treatment of  PC. The effect of  baseline  PSA level and  Gleason  score  on  the  choice  of treatment , the effectiveness of hormone deprivation and overall survival are evaluated.

In this  work  the  statistical analysis  of  incidence  and  mortality  from  malignant new growths of  the  population of  Ufa  in 2012 is submitted. Dynamics  of  the  main indicators on oncological  incidence  for  3 years is reflected and  comparison since 2002  is given, the structure and  the  gender and  age  analysis  of  malignant new  growths are  presented  in detail.  The index of  accumulation of  the  contingent, indicators of  relative  mortality  and year lethality are calculated.

The purpose of the  study  was to explore  the  possibilities of planar  scintigraphy breast (PSB) by using BSGI (Breast Specific Gamma  Imaging) in the early diagnosis of  breast cancer (BC). The study  were  included  120 women aged  31 to 81 (52,7+8,9) years  with suspected breast cancer.  PSB carried out using a portable gamma camera DILON 6800 with 99mTc-MIBI activity from  370 to 700 MBq and were imaged  in craniocaudal and mediolateral oblique projections.  Reliability of results  PSB was conducted in comparison with the  morphological and cytological results of biological material verification. Sensitivity, specificity, and accuracy in detecting breast cancer  of PSB was 95%, 98% and 97.5%, respectively.  Thus, the results showed the high information using this method in the diagnosis of breast cancer.

This article  provides  results  of  combined modality  treatment of  patients with  stage IIIA(N2) non-small cells lung cancer  with systematic and selective   lymph node  dissection. Elicit that  the  selective    lymph  node  dissection is valid for  patients with  stage IIIA(N2) squamous cell carcinoma and right-sided lung cancer when we provide combined modality treatment using adjuvant radiation therapy. Carrying out that  the systematic  lymph node dissection is extend   disease-free survival and  five-year survival rate  when  we  provide combined modality  treatment for  patients with  stage IIIA(N2) squamous cell carcinoma and left-sided lung cancer.

The results of treatment of 14 patients with gastric cancer with metastases to the bones of the skeleton  were analized, which was conducted by the stabilization of metastatic spine vertebroplasty, systemic  radionuclide therapy with  samarium-153 oksabifor and  intravenous infusion  by Zolendronic  acid 4 mg 1 time in 28 days. When applying this method decreased by stabilizing vertebral  pain occurred in the first 12 hours after vertebroplasty (cf. value 4.8±1,2 hours, from 30 minutes to 12 hours), the average pain intensity decreased to 4.5 ±0,6 (from 2 to 6). After the treatment of bone  metastases with samarium-153 oksa bifor,  pain intensity  decreased by 3,9 ± 0,3 days (range from 2 to 6) and reached the level of 0,9 ± 0,5 (from 0 to 2). Value pain scores before and after treatment was significantly different, and was P <0,0001.

Thus,  the  combination of  vertebroplasty, radionuclide therapy  with  samarium-153 oksabifor and  systemic  therapy with bisphosphonates (Zolendronic acid)  in patients with gastric  cancer  with bone  metastases can be treated in the  presence or threat of vertebral fractures, which gives an opportunity to expand the  indications for palliative radionuclide therapy and improve efficiency treatment of severe category of patients with multiple bone metastases and pain. The proposed approach allows us to quickly achieve durable  and pronounced reduction in pain intensity, significantly  reduce the need for analgesics.

In  the  article  are  the  incidence   of  breast  cancer, cervical  and  ovarian  cancer   in the  Republic of  Bashkortostan from  1993 to  2002  and  from  2003  to  2012 analyzed. A comparative analysis of the performance of the primary cancer incidence neoplasms of the female reproductive system  has done, level patterns the  dynamics  of disease  in different years, depending on age are obtained.

The article presents the results of a survey of 102 patients with injuries and diseases  of the  hip sustava.Dana assessment of the  quality of life on the  SF-36 questionnaire before and 12 months after the application of joint replacement. The results: the highest percentage of patients (76.4%) of the age group of 55 to 65 years. There was a high proportion of chronic somatic  diseases  (4.3 per patient). In assessing the quality of life in patients undergoing hip replacement surgery,  a statistically significant increase  in the quality of life in all respects as the physical and mental  component.

The brief  review  presents the  main  provisions  of  the  molecular-genetic theory  of carcinogenesis. The data  on the  presence of  overcelled  mechanisms regulating of  tissue homeostasis has done, which can be explained  by molecular  genetic  approach. The data of  the  interpretation of  the  theory  of  the  oncogene   based  on  different pathogenetic concepts is considered and  it allows you to continue the  development of tissue  theory  of carcinogenesis. The current understanding of the  structural and  functional characteristics of  the  microvasculature is described. Compelling   author’s  data  on the  effect of  oxygen therapy is provided  (normobaric and  hyperbaric  oxygen  therapy), and  the  modulation of antioxidant activity of plasma  by controlled differentiation of malignant cells with surgery (the change in the retrograde antegrade flow through the vascular reverse ).The significance of  microcirculation of  tissue  homeostasis has  determined. The updated position  of  the ground tissue microcirculatory theory  of carcinogenesis has formulated.

In the article the anatomical features of the peritoneum structure have been described in accordance with  the  medical  records  supplemented by the  author’s  illustrations.  The functional differences of various peritoneum areas are shown  based  on its structure. Also, issues  relating  to  the  anatomical features of  the  peritoneum such  as «hatches» and  its influence on the development of peritoneal carcinomatosis have been touched upon.

Since the  middle of the  previous  century  the  heterogeneity of breast cancer  became absolutely evident. This assumption was historically based on differences in clinical behavior and sensitivity to therapy. Treatment approach nowadays is based  primarily on clinical and morphological prognostic and predictive markers. Among morphologically derived markers the most  important are estrogen and progesterone receptors and HER2. Interestingly that tumors with expression of estrogen receptors and/or progesterone receptors that  showed also hyperexpression or amplification of HER2 have very poor outcome and low sensitivity to  all therapeutic  approaches.  Therefore we  want   to  summarize the  existing  clinical information that  is relevant to this topic.