In the article the chronology in the development of the scientific problem on microsurgery of internal organs and main veins are described, the information about departments and authors of investigations is adduced.

On a section material and in experiment on 195 not purebred dogs and 130 organocomplexis corpses of people working out and an anatomo-experimental substantiation of 8 new functionally active microsurgical biliodigestivе anastomoses, possessing sphincterniс and antireflux is carried out by properties. Use of principles microsurgery technique of operating solves problems of the reconstructive operations connected with application of the traditional surgical technique, such, as an inconsistency of seams biliodigestive ways, a peritonitis, relapse cicatricial stricturi, regurgitation cholangitis. In clinical practice the microsurgical technique and developed ways of biliodigestive anastomoses are applied at 67 patients with good result.

New ways of formation of microsurgical invagination late-side and end-terminal esophago-gastric anastomoses in the resection of the esophagus and cardia stomach are proposed in the experiment on animals. Objects of the experiment are 24 purebred dogs. Experimental approbation of microsurgical invagination PGA demonstrated the feasibility, reliability and high functionality of ways. The microsurgical techniques, single row of continuous seam without capture mucosa when creating anastomoses, allows to improve the immediate and distant results of operations. Anastomoses have high antireflux properties that due to constructive features, due to the inclusion in the anastomosis zone of duplikatory of alternate layers of muscles of the esophagus and stomach, forming an artificial sphincter, which is confirmed by the functional and morphological methods of research.

In the experimental study on 6 mongrel dogs the comparative morphometry of layers of the wall of abdominal section of esophagus and small intestine was carried out. Tworowed microsurgical esophago-enteroanastomosis “end-to-end” was formed in 12 animals. From the surplus of the outer case of the esophagus a sphincter-like structure was created. The dynamics of anastomosis adhesion in the postoperative period was studied macroscopically and on longitudinal histotopograms. A good epithelization has been recorded by the 7th day as well as a formation of thin and firm cicatrix without a rough fibrillar tissue by the 21st day.

The section on anatomy justification of microsurgical spleno- and mesorenal anastomosisperformedona sectionmaterial (54humancadavers). The studyof topography and anatomy features of splenic, renal and superior mesenteric veins were conducted, their morphological characteristics, the histology characteristics of vascular anastomoses, the parameters of their tightness and mechanical strength. Experimental studies carried out on 48 mongrel dogs. There have been five sets of experiments. The analyses of morphological and functional status of improved vascular anastomoses in the short and long periods after surgery were accomplished.

The article contains data of morphological analysis of wound healing and anastomosis of small and middle intestine, formed with appliance of microsurgical operative procedures, taking into consideration the stages of pathological process and type of microsurgical sutures. The article shows the meaning of peculiarities of microanatomy of the wall in small and middle intestine in case of obstruction and peritonitis, at implementation of microsurgical administration of operation. It also shows possibility and effectiveness of implementation of microsurgical technology while wound closure of small and middle intestine in peritonitis and application of colonic anastomosis at intestinal obstruction. Possibility of wound and anastomosis healing is proved.

In the article features morphological changes in the wall of the abdominal part of esophagus are described at two forms of its tumoral leasions: the squamous cell carcinoma and adenocarcinoma.

The article reflects the need for extensive use in the application of fundamental anatomical studies ileocecal region results research methods, quantitative estimates of the morphological parameters, that are opening new possibilities for diagnosis of pathological processes and development of new ways of operating.

Endoscopicanatomy,morphologicalchangesinmucousmembraneofgastroesophageal and gastroduodenal transitions, clinic in patients with duodenal ulcer were studied. Individual characteristics of each transition and some typical patterns were identified.

The article describes the developed and used in clinical practice a new method of combined surgical treatment of ingrown nail, changing the anatomic form of a nail bed with microsurgical suture.

The article is devoted to computer tomographical (CT) and gistotopographical comparisons in different subtypes of lung cancer. The study includes 39 cases of patients who undergone lung resection about cancer. Cross-sections of lungs on the level of most cancer spread were subjected to investigation. The data were comparised with CT data of the same patients before operation. These results allow to detalise CT research data of different anatomical subtypes of lung cancer.

In the article on thematerialof 105patientswith kidney cancerdislocationsof abdominal organs after nephrectomy are showed and analysed by the computer tomography.

In 104 patients who underwent surgery for acute destructive pancreatitis there was reviled immunological malfunction when different phases of disease. Patients were divided into three groups: background standard therapy (1 group), plasmapheresis introduction (2 group), adjunctive treatment with immunomodulator “Polioxidonium” course dose 78 mg. “Polioxidonium“ introduction into therapy of pancreonecrosis demonstrated not only immunomodulatory effect but also antiradical desintoxic that resulted in reduction of the number of suppurative complications and lethality.

In conditions of experimental acute pancreatitis of 60 guinea pigs and during the treatment of 89 patients with acute pancreatitis it was shown that the use of thioctic acid significantly reduces the manifestations of ischemic symptom , the severity of free radical processes and improves the patient's outcomes. The way for minimally invasive interventions under intraoperative ultrasound navigation consists in layered implementation of minimally invasive access of 2-3 cm in length, followed by the establishment of liquid aspiration from the wound channel of necrotic detritus, while emptying and drainaging the cavity under ultrasound control. The method allows one-step sanitation and drainage of cavity formations containing purulent dense necrotic tissue. This method is efficient, technically feasible in any surgical department, economically rational, since it does not require the purchase of additional surgical equipment. This complex of therapeutic measures allowed to reduce postoperative mortality in case of necrotizing pancreatitis to 9 % during the last three years.

The effectiveness of perftoran and recombinant superoxide dismutase in complex post-operative therapy in patients with acute intestinal obstruction was investigated. All patients (two groups) were combined. 49 patients received traditional complex therapy, 42 patients during the operation were given additional intravenous infusion recombinant superoxide dismutase and perftoran. Leucocyte intoxication index, the concentration of middle-weight molecules, dien conjugats and malone dialdehyde in serum, iron-induced and spontaneous chemiluminescence of blood serum, superoxide dismutase activity and catalase of erythrocyte at all patients were determined. It was established application of the perftoran and recombinant superoxide dismutase promotes the decrease of free-radical processes intensity, the reduction of endogenous intoxication and reduces the risk of the evident intestinal insufficiency development in patients with acute intestinal obstruction.

The comparative analysis of the treatment of 1136 patients with purulent- necrotic complications of diabetic foot syndrome (SDS ), treated with traditional surgical technique without suturing the wound ( 357 people ) and using the surgical benefits, based on the radical remove necrosis and closed wounds administered in combination with a targeted antibiotic therapy (779 persons). In the first group of amputation at the hip were performed in 35 cases (9.8%), atthe level of the tibia - in 63 patients (17.7%) and operations atthe foot suffered 259 (72.5 %) patients. In 171 cases (47.9%) were retried surgery and amputation at a higher level. Mortality rate was 16%. In the second group of amputation at the hip were performed in 13 cases (2 %), at the level of the tibia - in 38 patients (4.8%) and operations at the foot suffered 728 (93.2 %) patients. In the main group targeted application antibiotic therapy postoperative contributed favorable course of wound healing and primary wound healing in 71.9 % of cases. The progression of the inflammatory changes observed on the foot, respectively, in 28.1% cases that require repeated surgical implement, and 18 (2.3 %) patients had an amputation at the level of execution tibia or femur. Mortality reported at 3.3%. Application of the developed method for the treatment of purulent- destructive processes in patients with SDS has reduced the number of high amputation and mortality in 4 to 4.8 times.

Experimental-histological justification for the use of composite material «LitAr» in combination with oxytocin has done to replace residual cavities in liver for optimal terms of regeneration. The data on the optimization of epithelial connective tissue relations that in the proliferative phase creates preconditions for elimination of defect regenerate tissue-specific parenchymatous elements of the liver. In series with the addition of oxytocin residual cavity liver is filled organotypic tissue elements of the regenerate more quickly.

The clinical studies included 340 patients with trophic ulcers in lower limbs. It is for the first time that the therapeutic efficacy of local application of Miliacyle combined with magnetolasertherapy has been studied in 124 patients with trophic ulcers (experimental group). The patients of the control group I (84 patients) were treated with topically applied Miliacyle and laser radiation. The patients of control group II (80 patients) were treated only with Miliacyle. In the control group III (52 patients) the 1% solution of Dioxydinum and Oleum Hippopheae were used. In some patients of each group only conservative therapy was used, and some patients underwent preoperative treatment prior to autodermaplasty and operations on veins of lower limbs. On the basis of clinical and morphological studies it is found that the process of ulcer healing occurs most favorably as result of combined use of Miliacyle and magnetolasertherapy.

The article represents the results of investigation of reparative osteogenesis with using of composite material “LitAr” in the zone of pseudoarthrosis of long bones.

Experience of diagnostics and treatment of 263 children with the acquired intestinal impassability – intestines invagination is presented. The assessment is given to radiological and ultrasonic methods of diagnostics of an invagination. Advantage of ultrasonic research to a choice of medicaltactics thatled to extension of indications to conservative treatmentis proved.