Previously, we designed DTCM-glutarimide as a novel anti-inflammatory agent inhibiting macrophage activation. It also showed anti-inflammatory activity in vivo. In the present research, we evaluated the  anti-metastatic activity of this agent using  mouse  melanoma B16-F10 cells. DTCM-glutarimide inhibited  the cellular invasion in the Matrigel chamber assay, lowering matrix metalloproteinase 9 (MMP9) expression. It also induced  anoikis rather than  apoptosis in polyHEMA-coated plates.  It increased Bax and decreased Bcl-XL  expressions,  and  activated p53  lowereing  the  MDM2 expression. Thus, DTCM-glutarimide was found to inhibit cellular invasion and to induce anoikis in B16-F10 cells. It is non-toxic, and easily prepared, therefore, is considered to be a new candidate of anti-metastasis agent.

At the study of histological types of 128 patients with infiltrative type of breast cancer statistically  significant differences of the  quantitative ratio  of tissue  components, of the average values  Nottingham Prognostic   Index  (NPI)  and  the  total  score  of  malignancy established. It is shown  that  the definition of NPI effectively regardless of life expectancy of patients.

The article deals with the issues regarding the optimization of surgical treatment strategies in regional and metastatic cancer of the cardioesophageal junction which result in elimination of gastric fistulas. Shortand long-term effects of 238 surgeries between 1990 and 2010 have been studied. The benefits of surgical and endoscopic esophageal stenting over gastrostomy have been reported. The indication for and esophageal stent placement procedures have been defined. The article concludes that cytoreductive transpleural resection surgeries were not associated with increased post-operative mortality. However,  they resulted in prolongation of patient`s lives and creating proper conditions for delivering adjuvant chemotherapy.

92 patients with chronic anal fissure were treated depending on the cause of the disease and the magnitude of the basal pressure anal sphincter. It was found that, compared to the traditional method of surgical treatment, the use of “blind” stitch and developed modified suture, evenly healing the wound from the bottom, in combination with chemical sphincterotomy, contributes to significant acceleration of wound healing and causes fewer complications.

Results  of  surgery  performed over  a 15-year  period  on  328  patients over  60  years old with cancer  of the  thoracic  esophagus are analyzed. Concomitant diseases, results  of functional observation are reported. Data  of surgical and  combined treatment of cancer of  the  esophagus are  presented.   Types  of  operation,  modification of  resection and esophagoplasty are considered. Direct and remote results of treatment are considered.

Formation  of biliodigistiving anastomosis creates conditions for an ascending infection in the biliary system  that  provokes  the   reflux cholangitis. Studying of quality of life in the postoperative period gives the chance  to define  advantages of this or that  intervention.

The article proves indications and represents methods and late results of the surgery of 200 resectable stomach cancer patients. The treatment includes perioperative chemotherapy, neoajuvant intraarterial regional  chemotherapy and  trans-arterial chemoembolization of the  hepatic artery  in the  presence of  liver metastasis. The combined modality  treatment shows  visible improvement of  short-term and  late  treatment results  when  applying  the above-described methods.

The  combination  of the transurethral  vaporization,  transurethral  resection  of bladder cancer  together with the combined chemotherapy was applied( patent application no. 2010127350/20 (038956) d.d. 5.07.10 “Bladder cancer  treatment method”). The developed system of a pseudo-multifactorial analysis was used to study the treatment results. The study proves that the combination of the transurethral resection and transurethral vaporization lets decrease both the number of bladder cancer  recurrences and the number of complications. The treatment of bladder cancer  patients at the stage Т2аN0M0 with the application of the systemic polychemotherapy and doxorubicin adjuvant chemotherapy according to the schedule lets the recurrence free survival get 93.0%. The results of our research prove the competence of the endoscopic organ preservation treatment to be applied to treat invasive cancers.

The results of experimental study which are performed to 28 breed  dogs are analyzed in this project.  Three series of experimental study  were  carried out for the  solution  of the object in view. The first series (control group): 8 dogs without treatment. The second series (control group): 10 dogs  which  have  only passed through the  complex  with  medication therapy. The third series (the basic one) 10 dogs, the direct current was used in the complex of treatment together with medication therapy. On the   assumption of experimental data it was  discovered that  the  application of  small dose  of  direct  current in the  complex  of treatment exerts antiphlogistic action, assists to accelerated rejection of necrotic tissues and remitting of inflammatory process, and also stimulates regenerative processes in pancreas by that  allows a decrease of lethality at experimental animals from 60% to 30%.

The problem  of treatment of patients with cicatricial defects of a skin concerns one of actual sections  of medicine. The new method of treatment of hypotrophic hems by a beam of the laser from  a long wave of 540  nanometers, duration of impulses 1 - 2 nanoseconds (a mode  of generation Q – sw),  energy  of an impulse  (50  - 150 мДж)  and  frequency of following of an impulse (1-4 Hz) is offered. Its influence on microcirculation of a bottom of a hem that promotes reduction of depth of a hem, improvement of its consistence is proved. At use of a method healing  passes  during  30 – 38 days,  with formation a normotrophic hem, skin color restoration.

145 recipients of kidneys analyzed, operated from 2006  to 2010. Of these 68 (46,%) patients with anuria period of more than 3 years. A method for treating patients with prolonged anuria in renal transplantation consists of three phases: preoperative, perioperative, and postoperative. The study is divided into three groups. The first group of patients was with prolonged anuria without urological examination and treatment. The second group with prolonged anuria, but carried out perioperative and postoperative phases. In the third group  were held all three stages of treatment for patients with prolonged anuria in renal transplantation. This study proves the effectiveness of the proposed method of treatment. Improved results in both immediate and late postoperative period. When you run the full course of the proposed method of diagnosis and treatment of patients with prolonged anuria in renal transplantation to reduce the number of urologic complications by 13% over a three year period of observation.

The causes of development of seam’s lack of the gastrointestinal tract of patients who underwent surgery because of complications of gastric ulcer and duodenal ulcer are studied. The classification of forms of seam’s lack of duodenal stump and gastroenteroanastomosis is presented. The new  approaches in diagnosis and  complex  treatment of  patients with seam’s lack of the gastrointestinal tract are offered.

Article is devoted to the analysis of own material on performance of laparoscopic gastric banding for the purpose of treatment of morbidny obesity. Authors considered most often meeting difficulties performing the  operation and  frustration arising in the  postoperative period  and  complications. On the  basis of the  saved-up experience the  thesis  about need of technical ensuring operation and thorough preparation of the medical personnel and the patient is given.

Incidence  of vulvar cancer  in reproductive patients and  peculiarities  of clinical course of the disease  have been  studied. 839  vulvar cancer  patients aged  20-90 years have been treated at Gynecology Department of Rostov Research Oncologic Institute within the latest 30 years. The reproductive group  (20-50 years of age)  included 64 patients (7,6%). Early stages of vulvar cancer in the reproductive group were diagnosed more often than in elderly patients. Neurodystrophic changes of vulvar in young patients were much rarely observed in comparison with elderly patients. Almost 80% of patients under 40 years of age had human papilloma  virus; in the  group  of 41-50  years of age  – 50%; whereas in the  elderly group contamination with  human papilloma  virus was  observed only in single cases  – 0,48%. Organ-sparing operations performed by strict individual approach are possible in the group of young  patients. Vulvar cancer, in particular with advanced malignant process, requires complex   treatment  including   neoadjuvant  and   multi-course adjuvant  chemotherapy. Recurrent disease in reproductive patients is observed less frequent than in elderly patients. Chemotherapy is appropriate in cases of recurrent disease in order to improve  operability.

Among 113 patients operated on at the RPTD of pulmonary tuberculosis, bronchial condition has been  studied in a prospective point  of intersection, compared visual and  morphological  picture.  As a result patients were divided into 2 groups:  1st found non-specific bronchitis, endoscopically and histologically confirmed 44 patiens (38,9%), 2nd endoscopically and histologically bronchitis  is not detected 69 (61,1%) patients. Found that  is necessary to make rapid biopsy patients with ongoing bacterial  in the preoperative period in the intended place of intersection of the bronchus, even if the visual signs of inflammation of the bronchial  mucous  membrane is not detected as well as perform FBS in the near future before the operation. It’s required to do PBS control after treatment of inflammatory changes in the LDP.

The article  presents a retrospective analysis  of  patients admitted to  the  Republican out-patient clinic of cardiology   with a diagnosis of acute  myocardial  infarction, no later than  4 hours  from  the  time  of  occurrence  of  symptoms  of  acute  coronary  syndrome. The relationship infarct related  artery  with the development of atrioventricular conduction disturbances in patients undergoing stenting and / or balloon angioplasty of the coronary arteries. A group of  patients with persistent atrioventricular conduction disturbances that took place  in the future  implantation of a permanent pacemaker.

The examination results  of 296 patients suffering from  severe  abdominal pathology in combination with intra-abdominal hypertension are analyzed  in the article. Physical parameters of the  abdominal space  of 30 patients during  video-laparoscopic operations are studied. 3 volume  characteristics of the  abdominal space  are given by the  article writers: reserve volume, maximal volume and physiologic volume, all of them being individual marks depending on sex, age  and  body  type.  The package of measures directed on the  3 main abdominal space components is proposed.

In a normal immune  response develops only to foreign antigens or modified their own. Aging and certain diseases lead to the fact that there are antibodies directed against its own tissues,  which are perceived  as foreign tissue,  as antigens, develop  an autoimmune reaction.  The paper  presents data  on the  twenty-four natural autoantibodies to one  or more antigens of a particular organ  orientation.

Advances  in the diagnosis and  treatment of cancer  have greatly enhanced the life expectancy of women with cancer.  As a result, there is a growing population of adolescent and  adult long-term survivors of cancer.  The continuous development of techniques of assisted human reproduction has  led to important strategies in an  attempt to maintain reproductive function in patients subjected to chemoand  radiotherapy treatment of cancer, among them cryopreservation of embryos, gametes, and  ovarian cortical tissue.