Clinical Characteristics and Features of Noninvasive Breast Cancer
https://doi.org/10.24060/2076-3093-2025-15-3-244-250
Abstract
Introduction. This article presents the study of 110 female patients diagnosed with stage 0 breast cancer conducted at the P. Hertsen Moscow Oncology Research Institute between 2023 and 2024. Materials and methods. By histological type, ductal carcinoma in situ (Tis, DCIS) predominated in 100/110 cases (90.9%), followed by Paget’s disease (Tis, Paget) in 7/110 (6.4%), and lobular carcinoma in situ (Tis, LCIS) in 3/110 (2.7%). Mastectomy was performed in 17 pa‑ tients (15.5%), skin-sparing mastectomy with reconstruction in 44 (40%), and breast-conserving surgery in 49 (44.5%). Results. According to routine histological examination, progression of DCIS was identified in 42/110 patients (38.2%). Among them, stage I breast cancer was diagnosed in 33.6% and stage II in 4.5%. In routine morphological examination, positive resection margins (R1) were detected in 15 patients (13.6%). Discussion. Breast MRI in non-invasive breast can‑ cer is an essential procedure for determining disease extent, assessing multifocality or multicentricity, and thus guiding the decision on breast-conserving surgery versus mastectomy. Another important issue is the need to evaluate sentinel lymph nodes in cases of non-invasive breast cancer. Conclusion. Local recurrences of breast cancer in the analyzed group were diagnosed in 2 patients (1.8 ± 1.6%). Progression of stage 0 breast cancer to higher stages, i.e., cTis → pT+, was observed in 42/110 patients (38.2%). Despite the extent of disease (mean size of carcinoma in situ was 42 mm), breastconserving surgery or nipple-/skin-sparing mastectomy with reconstruction were performed in 93% of cases. Thus, carcinoma in situ may progress to higher stages in about 40% of patients. The role of diagnostic methods in assessing breast cancer stage is therefore crucial for selecting an optimal surgical management.
Keywords
breast cancer,
carcinoma in situ,
stage progression,
mammography,
tomosynthesis,
magnetic resonance imaging,
biopsy,
mastectomy,
recurrence,
breast-conserving surgery
Supporting agencies: This work is not funded.
About the Authors
Еlena A. Rasskazova
P.A. Hertsen Moscow Research Oncology Institute — branch of the National Medical Research Center for Radiology
Russian Federation
Russian Federation
Еlena А. Rasskazova — Cand. Sci. (Med.), Unit of Oncology and Reconstructive Surgery of Breast and Skin Tumors
Moscow
Irina M. Onofriychuk
Moscow Multidisciplinary Clinical Center “Kommunarka”
Russian Federation
Russian Federation
Irina M. Onofriychuk — Cand. Sci. (Med.), 1st Oncology Unit (skin, soft tissues, breast)
Moscow
Galina A. Gekht
P.A. Hertsen Moscow Research Oncology Institute — branch of the National Medical Research Center for Radiology
Russian Federation
Russian Federation
Galina A. Gekht — Unit of Oncology and Reconstructive Surgery of Breast and Skin Tumors
Moscow
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Review
For citations:
Rasskazova Е.A., Onofriychuk I.M., Gekht G.A. Clinical Characteristics and Features of Noninvasive Breast Cancer. Creative surgery and oncology. 2025;15(3):244-250. (In Russ.) https://doi.org/10.24060/2076-3093-2025-15-3-244-250
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